Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Jankowska, Milena; Wiśniewska, Justyna; Fałtynowicz, Łukasz; Lapied, Bruno; Stankiewicz, Maria

doi:10.3390/molecules24203775

Cited by 13 publications

(8 citation statements)

References 75 publications

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“…In several studies, plant-derived substances were used in binary mixtures with synthetic insecticides on insects due to increase of toxic properties, mainly by extension of mode of action on different targets obtaining synergistic effects. In many studies, the application of both plant-derived and synthetic insecticide with obtained synergism or additivity, were performed without creating their mixtures before the application [ 51 , 52 ]. First, we focused on a more practical aspect, where the mixtures were created to avoid multiplication of the field application.…”

Section: Resultsmentioning

confidence: 99%

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Spochacz

Szymczak

Chowański

et al. 2020

Toxins

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Synthetic insecticides are widely used for crop protection both in the fields and in the food stored facilities. Due to their toxicity, and assumptions of Integrated Pest Management, we conducted two independent experiments, where we studied the influence of Solanum nigrum unripe fruit extract on the toxicity of an organophosphorus insecticide fenitrothion. In the first variant of the experiment, Tenebrio molitor larvae were fed with blended fenitrothion (LC50) and the extract in four concentrations (0.01, 0.1, 1 and 10%) in ratio 1:1 for 3 days. In the second variant, a two-day application of fenitrothion (LC40) was preceded by a one-day extract treatment. The first variant did not show any increase in lethality compared to fenitrothion; however, ultrastructure observations exhibited swollen endoplasmic reticulum (ER) membranes in the midgut and nuclear and cellular membranes in the fat body, after application of blended fenitrothion and extract. An increased amount of heterochromatin in the fat body was observed, too. In the second variant, pre-treatment of the extract increased the lethality of larvae, decreased the level of glycogen and lipids in the fat body and disrupted integrity of midgut cellular membranes. S. nigrum extract, applied prior to fenitrothion treatment can be a factor increasing fenitrothion toxicity in T. molitor larvae. Thus, this strategy may lead to decreased emission of synthetic insecticides to the environment.

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Section: Resultsmentioning

confidence: 99%

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Spochacz

Szymczak

Chowański

et al. 2020

Toxins

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show abstract

“…In particular, the presence of exocyclic double bonds in some of their structures may contribute to inducing toxicity in insects . Taken together, these mixtures may also have a multi-target action, interacting with GABA, AChE and octopaminergic systems (Jankowska et al 2017(Jankowska et al , 2019.…”

Section: Insecticidal Activitymentioning

confidence: 99%

Essential oils from three Algerian medicinal plants (Artemisia campestris, Pulicaria arabica, and Saccocalyx satureioides) as new botanical insecticides?

Ammar

Hendel

Sarri

et al. 2020

Environ Sci Pollut Res

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Medicinal and aromatic plants represent an outstanding source of green active ingredients for a broad range of real-world applications. In the present study, we investigated the insecticidal potential of the essential oils obtained from three medicinal and aromatic plants of economic importance in Algeria, Artemisia campestris, Pulicaria arabica, and Saccocalyx satureioides. Gas chromatography coupled with mass spectrometry (GC-MS) was used to study the essential oil chemical compositions. The three essential oils were tested against a mosquito vectoring filariasis and arboviruses, i.e., Culex quinquefasciatus, a fly pest acting also as pathogens vector, Musca domestica, and an agricultural moth pest, i.e., Spodoptera littoralis, using WHO and topical application methods, respectively. The essential oil from A. campestris, containing β-pinene (15.2%), α-pinene (11.2%), myrcene (10.3%), germacrene D (9.0%) (Z)-β-ocimene (8.1%) and γ-curcumene (6.4%), showed remarkable toxicity against C. quinquefasciatus (LC 50 of 45.8 mg L −1) and moderate effects (LD 50 of 99.8 μg adult −1) against M. domestica. Those from P. arabica and S. satureioides, containing epi-α-cadinol (23.9%), δ-cadinene (21.1%), α-cadinol (19.8%) and germacrene D-4-ol (8.4%), and thymol (25.6%), α-terpineol (24.6%), borneol (17.4%) and p-cymene (11.4%), respectively, were more active on S. littoralis showing LD 50 values of 68.9 and 61.2 μg larva −1 , respectively. Based on our results, the essential oil from A. campestris may be further considered a candidate ingredient for developing botanical larvicides.

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“…Jankowska et al demonstrated that menthol enhances the efficiency of bendiocarb by increasing Ca 2+ concentration, as well as activating octopamine receptors and the protein kinase A (PKA) signaling pathway. 43 These achievements may be used to develop modern insecticide formulations that are more effective against pests. This achievement may be used to develop more powerful formulations of modern insecticides.…”

Section: Application Of Protein Kinases In Increasing the Efficiency ...mentioning

confidence: 99%

“…Such a mechanism may exist for the menthol in the essential oils fraction. Jankowska et al demonstrated that menthol enhances the efficiency of bendiocarb by increasing Ca 2+ concentration, as well as activating octopamine receptors and the protein kinase A (PKA) signaling pathway . These achievements may be used to develop modern insecticide formulations that are more effective against pests.…”

Section: Protein Kinases As Potential Targets For Insecticides and He...mentioning

confidence: 99%

Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals

Sun

Wang

Gao

et al. 2023

J. Agric. Food Chem.

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Using agrochemicals against pest insects, fungi, and weeds plays a major part in maintaining and improving crop yields, which helps to solve the issue of food security. Due to the limited targets and resistance of agrochemicals, protein kinases are regarded as attractive potential targets to develop new agrochemicals. Recently, a lot of investigations have shown the extension of agrochemicals by targeting protein kinases, implying an increasing concern for this kind of method. However, few people have summarized and discussed the targetability of protein kinases contributing to the development of agrochemicals. In this work, we introduce the research on protein kinases as potential targets used in crop protection and discuss the prospects of protein kinases in the field of agrochemical development. This study may not only provide guidance for the contribution of protein kinases to the development of agrochemicals but also help nonprofessionals such as students learn and understand the role of protein kinases quickly.

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Menthol Increases Bendiocarb Efficacy Through Activation of Octopamine Receptors and Protein Kinase A

Cited by 13 publications

References 75 publications

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Solanum nigrum Fruit Extract Increases Toxicity of Fenitrothion—A Synthetic Insecticide, in the Mealworm Beetle Tenebrio molitor Larvae

Essential oils from three Algerian medicinal plants (Artemisia campestris, Pulicaria arabica, and Saccocalyx satureioides) as new botanical insecticides?

Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals

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