Mentalizing in schizophrenia: A multivariate functional MRI study

Martin, Andrew K.; Dzafic, Ilvana; Robinson, Gail; Reutens, David C.; Mowry, Bryan

doi:10.1016/j.neuropsychologia.2016.10.013

Cited by 20 publications

(24 citation statements)

References 43 publications

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“…In a recent study, Martin et al 26 identified a common network in patients with schizophrenia and healthy controls that separate the viewing of intentional and random ATT animations. However, behavioral data showed that patients performed worse on the ToM tasks compared to the controls.…”

Section: Bliksted Et Almentioning

confidence: 99%

Hyper- and Hypomentalizing in Patients with First-Episode Schizophrenia: fMRI and Behavioral Studies

Bliksted

Frith

Videbech

et al. 2018

Schizophrenia Bulletin

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Mentalizing deficits in FES consists of hypo- and hypermentalizing. The neural pattern of FES patients is consistent with deficits in the ability to switch off mentalizing processes in potentially social contexts, instead increasing them when intentionality is not forthcoming. Overall, results demonstrate complexities of theory of mind deficits in schizophrenia that should be considered when offering social cognitive training programs.

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Section: Bliksted Et Almentioning

confidence: 99%

Hyper- and Hypomentalizing in Patients with First-Episode Schizophrenia: fMRI and Behavioral Studies

Bliksted

Frith

Videbech

et al. 2018

Schizophrenia Bulletin

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“…Schizophrenia researchers have subsequently conducted fMRI studies to record neural activity while people with schizophrenia and healthy controls view the Abell et al animations, with some contradictory results (see Das, Lagopoulos, Coulston, Henderson, & Malhi, 2012;Martin, Dza, Robinson, Reutens, & Mowry, 2016;Pedersen et al, 2012), while several behavioural studies have used different variants of Abell et al's task, again with some mixed results (see Bliksted, Shiho, & Koelkebeck, 2016, for a comprehensive meta-analysis and review of behavioural and imaging studies using the animated triangles task with individuals with autism or schizophrenia). For example, Russell, Reynaud, Herba, Morris, and Corcoran (2006) used the same animated triangles stimuli and instructions as Abell et al and found that people with schizophrenia spontaneously generated fewer mental-state terms than controls when describing the GD and TOM trials, while subgroups of paranoid and passive patients 'read too much' into the randomly moving shapes (i.e., they inappropriately ascribed intent in the random condition).…”

Section: Limitationsmentioning

confidence: 99%

“…Schizophrenia researchers have subsequently conducted fMRI studies to record neural activity while people with schizophrenia and healthy controls view the Abell et al . animations, with some contradictory results (see Das, Lagopoulos, Coulston, Henderson, & Malhi, ; Martin, Dza, Robinson, Reutens, & Mowry, ; Pedersen et al ., ), while several behavioural studies have used different variants of Abell et al . 's task, again with some mixed results (see Bliksted, Shiho, & Koelkebeck, , for a comprehensive meta‐analysis and review of behavioural and imaging studies using the animated triangles task with individuals with autism or schizophrenia).…”

Section: Introductionmentioning

confidence: 99%

Impairments of spontaneous and deliberative mentalizing co‐occur, yet dissociate, in schizophrenia

Langdon

Flynn

Connaughton

et al. 2017

British J Clinic Psychol

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Findings People with schizophrenia were less likely than controls to spontaneously attribute causal mental states when viewing dynamic signals of emotionally driven and goal-driven behaviours. These impairments were even more pronounced when participants were instructed to think of the stimuli as people, suggesting that perceiving others in social roles does not prompt people with schizophrenia to anthropomorphize about others as agents motivated by their own inner worlds. Impairments of spontaneous mentalizing were found to co-occur independently with explicit mentalizing deficits in schizophrenia, consistent with the claim that humans can access two distinct systems for understanding others' minds. Findings suggest that interventions to improve conscious deliberative mentalizing in schizophrenia may not be enough; we also need to target implicit mentalizing processes. Limitations The patient sample was chronic and only mildly symptomatic. As such, findings cannot be generalized to other stages and phases of the illness. All patients were also medicated, allowing for the possibility that automatic responses to socially salient stimuli may have been pharmacologically attenuated. Future research may examine whether unmedicated young people at ultra-high risk of psychosis show a similar profile of mentalizing impairment. Future work may also examine whether impairments of deliberative and spontaneous mentalizing associate differentially with social functioning and different cognitive domains in schizophrenia.

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“…However, results have been inconsistent. While Das et al found reduced activation of the right superior temporal gyrus (STG), the temporo-parietal junction (TPJ) and bilateral inferior frontal gyri (IFG) (Das et al, 2012a;2012b), Martin et al showed increased activation of bilateral IFG, left STG and left caudate nucleus (Martin et al, 2016). Finally, Bliksted et al found that patients hyper-mentalized during non-social stimuli, accompanied by increased activation of the anterior medial prefrontal cortex (Bliksted et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia

Dietz

Zhou²,

Veddum

et al. 2019

Preprint

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Schizophrenia is a tenacious psychiatric disorder thought to result from synaptic dysfunction. While symptomatology is traditionally divided into positive and negative symptoms, abnormal social cognition is now recognized a key component of schizophrenia. Nonetheless, we are still lacking a mechanistic understanding of how aberrant synaptic connectivity is expressed in schizophrenia during social perception and how it relates to positive and negative symptomatology. We used fMRI and dynamic causal modelling (DCM) to test for abnormalities in synaptic efficacy in twenty-four patients with first-episode schizophrenia (FES) compared to twenty-five matched controls performing the Human Connectome Project (HCP) social cognition paradigm. Patients had not received regular therapeutic antipsychotics, but were not completely drug naïve. Our data reveal an increase in excitatory feedforward connectivity from motion-sensitive V5 to posterior superior temporal sulcus (pSTS) in patients compared to matched controls. At the same time, were less accurate than controls in judging social stimuli from non-social stimuli. Crucially, patients with a higher degree of positive symptoms had more disinhibition within pSTS, a region computationally involved in Theory of Mind. We interpret these within a predictive coding framework where increased feedforward connectivity may encode aberrant prediction errors from V5 to hierarchically higher pSTS and local disinhibition within pSTS may reflect aberrant encoding of the precision of cortical representations about social stimuli.

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Mentalizing in schizophrenia: A multivariate functional MRI study

Cited by 20 publications

References 43 publications

Hyper- and Hypomentalizing in Patients with First-Episode Schizophrenia: fMRI and Behavioral Studies

Hyper- and Hypomentalizing in Patients with First-Episode Schizophrenia: fMRI and Behavioral Studies

Impairments of spontaneous and deliberative mentalizing co‐occur, yet dissociate, in schizophrenia

Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia

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