Mental symptoms and quality of life in lipoprotein apheresis patients in comparison to hemodialysis patients, platelet donors and normal population

Stasiewski, E.; Christoph, Marian; Christoph, A Fux; Bittner, Antje; Weidner, Kerstin; Julius, Ulrich

doi:10.1016/j.atherosclerosissup.2015.02.035

Cited by 12 publications

(7 citation statements)

References 35 publications

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“…In a cross-sectional study, we compared the psychological situation and the quality of life of LA patients (n=41) with patients on hemodialysis (HD; n=41) and healthy thrombocyte donors (n=29). 43 LA and HD patients had similarly increased presence of psychological symptoms with concurrent decreased quality of life. Thus, an accompanying psychological treatment may be helpful.…”

Section: Patient-focused Perspectives Such As Quality Of Life Patienmentioning

confidence: 88%

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

Julius¹

2016

MDER

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This review reports the current situation with respect to therapeutic options (lifestyle and drugs) reducing the concentrations of atherogenic low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]). Three lipoprotein apheresis (LA) principles have been realized: precipitation, filtration, and adsorption. Available LA methods are herein described in detail – major components, pumps, extracorporeal volume, treated volume, and anticoagulation. General features of all LA methods as well as pleotropic effects are elaborated. Indications for LA therapy are quoted: homozygous familial hypercholesterolemia (HCH), severe HCH, and isolated elevation of Lp(a) and progress of atherosclerotic disease. A major focus is on the evidence of the effect of LA on cardiovascular outcome data, and the most important publications are cited in this context. The best studies have been performed in patients with elevated Lp(a) in whom cardiovascular events were reduced by more than 80%. Major adverse effects and contraindications are listed. The impact of an LA therapy on patient quality of life and the requirements they have to fulfill are also highlighted. Finally, the future role of LA in treating high-risk patients with high LDL-C and/or high Lp(a) is discussed. It is probable that the significance of LA for treating patients with elevated LDL-C will decrease (with the exception of homozygous familial HCH) due to the application of PCSK9 inhibitors. The antisense oligonucleotide against apolipoprotein(a) could replace LA in patients with high Lp(a), provided positive outcome data are generated.

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Section: Patient-focused Perspectives Such As Quality Of Life Patienmentioning

confidence: 88%

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

Julius¹

2016

MDER

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“…40 A recently published large study demonstrated that patients undergoing lipoprotein apheresis or hemodialysis exhibit higher levels of psychological symptoms than normal subjects with no history of extracorporeal treatment, and which are associated with reduced health-related quality of life and the potential for worse clinical outcomes. 41 Despite these limitations, lipoprotein apheresis is a valuable treatment option and is likely to remain so in patients with severely elevated LDL-C or who are unresponsive to drug therapy and in patients with homozygous FH. [42][43][44] Alirocumab 75 to 150 mg Q2W added to statins with or without other LLT reduces LDL-C concentrations by 44% to 73%, and is well tolerated.…”

Section: Discussionmentioning

confidence: 99%

Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis: Rationale and design of the ODYSSEY ESCAPE trial

Moriarty

Parhofer²,

Babirak³

et al. 2016

Journal of Clinical Lipidology

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“…Kejadian depresi pada pasien CKD 3 -4 kali lebih tinggi dari pada populasi umum dan 2 -3 kali lebih tinggi dari pada pasien dengan penyakit kronis lainnya (Shirazian et al, 2016).Kasus depresi pada pasien hemodialisis sering tidak diketahui karena terapi hemodialisis hanya fokus pada pengurangan gejala yang diakibatkan oleh gangguan metabolik akibat kerusakan ginjal tanpa memperhatikan pasien sebagai individu yang harus menghadapi masalah fisik dan psikologis selama menjalani hemodialisis (Meader et al, 2011;Nayana et al, 2016). Berdasarkan penelitian didapatkan data bahwa lebih dari 70% pasien hemodialisis mengalami gejala depresi yang bisa berakibat pada bunuh diri dan kematian sehingga membutuhkan psikoterapi untuk meningkatkan kualitas hidup pasien (Cuijpers et al , 2013;Stasiewski et al, 2015). Salah satu psikoterapi yang bisa digunakan pada pasien depresi adalah Cognitive Therapy (CT) yang bertujuan untuk membantu individu mengidentifikasi pikiran negatif dan merubahnya menjadi pikiran positip berdasarkan pikiran individu sendiri sehingga individu bisa melawan pikiran negatif yang tidak rasional (Hedayati et al, 2012).…”

Section: Pendahuluanunclassified

Perbedaan Pengaruh Cognitive Therapy (Ct) Dan Logo Therapy Terhadap Depresi Pada Pasien Dengan Hemodialisis Di Rs Wava Husada Kepanjen

Agustiningsih¹,

Soeharto²,

Kapti³

2017

mesencephalon

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: Patient with chronical diease such as Hemodialysis more likely need psycotherapy because until now medical atention only focus on physical aspect. Psycotherapy that can be used on Hemodialysis that going through depression is cognitive therapy and logo therapy. This study was to analysed the difference of influence between cognitive therapy and logo therapy on Hemodialysis patient that going through depression. This study was used quasi experimental pre–post test design. Respondent taking part in this study was 15 respondent for cognitive therapy and 15 respondent for logo therapy with puporsive sampling procedure. Study was conducted on Hemodialysis unit on RS Wava Husada Kepanjen from 21 April until 26 Mey 2017. Data analysis used on this study was dependent t test and independent t test. Dependent t test analysis showed significant value is 0,000 (less than < 0,05).Analysis showed significant value is 0,000 (less than < 0,05) that means there is difference between cognitive therapy and logo therapy to decrease depression on hemodialysis patient with mean value cognitive therapy (1,62) dan logo therapy (3,82). Conclussion on this study is that logo therapy more effective to reduce depression on Hemodialysis patient than cognitive therapy so logo therapy can applicated in hemodialysis patient.Keyword : cognitive therapy, logo therapy, depression in hemodialysis patient Abstrak : Pasien dengan penyakit kronis dengan hemodialisis diperlukan psikoterapi karena selama ini fokus penanganan di pelayanan kesehatan hanya pada masalah fisik. Psikoterapi yang bisa digunakan pada pasien hemodialisis yang mengalami depresi adalah cognitive therapy dan logo therapy. Penelitian ini bertujuan untuk menganalisis perbedaan pengaruh cognitive therapy dan logo therapy terhadap depresi pada pasien dengan hemodialisis. Penelitian ini menggunakan desain penelitian quasi experimental pre – post test design. Jumlah responden dalam penelitian ini 15 responden untuk kelompok cognitive therapy dan 15 responden untuk kelompok logo therapy yang didapatkan dengan menggunakan tehnik purposive sampling. Penelitian dilakukan di unit hemodialisis RS Wava Husada Kepanjen mulai tanggal 21 April – 26 Mei 2017. Pemberian terapi dilakukan oleh peneliti sendiri yang telah mendapatkan lisensi dari perawat spesialis jiwa. Analisis data yang digunakan dalam penelitian ini adalah dependent t test dan independent t test. Hasil analisis dependent t test pada kelompok sebelum dan setelah diberikan cognitive therapy dan logo therapy didapatkan hasil nilai signifikansi 0,000 < 0,05 yang berarti bahwa ada perbedaan skor depresi antara sebelum dan sesudah diberikan pemberian cognitive therapy dan logo therapy Sedangkan hasil analisis independent t test menunjukkan bahwa nilai signifikansi 0,000 < 0,05 yang berarti ada perbedaan yang bermakna antara cognitive therapy dan logo therapy dalam menurunkan depresi pada pasien dengan hemodialisis yaitu dengan rata – rata penurunan terhadap depresi untuk cognitive therapy dan logo therapy masing – masing yaitu 1,62 dan 3,86. Hal ini berarti bahwa logo therapy lebih efektif menurunkan depresi pada pasien hemodialisis dari pada cognitive therapy. Berdasarkan hasil penelitian tersebut diharapkan bahwa logo therapy bisa diaplikasikan sebagai alternatif psikoterapi pada pasien hemodialisis.Kata Kunci: cognitive therapy, logo therapy, depresi pada pasien hemodialisis

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Mental symptoms and quality of life in lipoprotein apheresis patients in comparison to hemodialysis patients, platelet donors and normal population

Cited by 12 publications

References 35 publications

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

Lipoprotein apheresis in the management of severe hypercholesterolemia and of elevation of lipoprotein(a): current perspectives and patient selection

Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis: Rationale and design of the ODYSSEY ESCAPE trial

Perbedaan Pengaruh Cognitive Therapy (Ct) Dan Logo Therapy Terhadap Depresi Pada Pasien Dengan Hemodialisis Di Rs Wava Husada Kepanjen

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