Mental stress, hypertension and the baroreflex: what's new?

Julien, Claude

doi:10.1097/hjh.0b013e32831cf02d

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The baroreflex is the main feedback mechanism regulating BP and is an important contributor to short‐term BP and heart rate (HR) variability (Cerutti et al 1994). Impairment of baroreflex function characterizes overt forms of both experimental hypertension (McCubin et al 1956; Nosaka & Omamoto 1970; Matsuguchi & Schmid, 1982; Su et al 1986) and human essential hypertension (Brotman et al 2007; Julien, 2009); however, clinical (Bovy et al 1983; Watkins et al 1996) and experimental (Lawler et al 1991; Sanders & Lawler, 1992) data on baroreflex function in borderline hypertensive subjects are conflicting.…”

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confidence: 99%

“…In our experiments, the BP of BHRs was 135/99 mmHg, corresponding to high‐normal to mild hypertension in humans (Mancia et al 2009). Although BHRs have a genetic predisposition for hypertension, they will not develop overt hypertension spontaneously unless exposed to stress or elevated salt intake (Lawler et al 1991; Sanders & Lawler, 1992), both of which are important risk factors in the pathogenesis of human hypertension (Larkin, 2005; Brotman et al 2007; Julien, 2009). We hypothesized that BHRs have altered neurogenic control of the cardiovascular system, making them vulnerable to environmental stress even in conditions of regular salt intake.…”

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confidence: 99%

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Autonomic mechanisms underpinning the stress response in borderline hypertensive rats

Šarenac

Lozić

Drakulić

et al. 2011

Experimental Physiology

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This study investigates blood pressure (BP) and heart rate (HR) short-term variability and spontaneous baroreflex functioning in adult borderline hypertensive rats and normotensive control animals kept on normal-salt diet. Arterial pulse pressure was recorded by radio telemetry. Systolic BP, diastolic BP and HR variabilities and baroreflex were assessed by spectral analysis and the sequence method, respectively. In all experimental conditions (baseline and stress), borderline hypertensive rats exhibited higher BP, increased baroreflex sensitivity and resetting, relative to control animals. Acute shaker stress (single exposure to 200 cycles min-1 shaking platform) increased BP in both strains, while chronic shaker stress (3-day exposure to shaking platform) increased systolic BP in borderline hypertensive rats alone. Low- and high-frequency HR variability increased only in control animals in response to acute and chronic shaker (single exposure to restrainer) stress. Acute restraint stress increased BP, HR, low- and high-frequency variability of BP and HR in both strains to a greater extent than acute shaker stress. Only normotensive rats exhibited a reduced ratio of low- to high-frequency HR variability, pointing to domination of vagal cardiac control. In borderline hypertensive rats, but not in control animals, chronic restraint stress (9-day exposure to restrainer) increased low- and high-frequency BP and HR variability and their ratio, indicating a shift towards sympathetic cardiovascular control. It is concluded that maintenance of BP in borderline hypertensive rats in basal conditions and during stress is associated with enhanced baroreflex sensitivity and resetting. Imbalance in sympathovagal control was evident only during exposure of borderline hypertensive rats to stressors.

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confidence: 99%

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confidence: 99%

Autonomic mechanisms underpinning the stress response in borderline hypertensive rats

Šarenac

Lozić

Drakulić

et al. 2011

Experimental Physiology

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“…Blood pressure (BP) level correlates with emotional status, behavioral patterns, and current mental state. At present hypertension proved to be a risk factor for memory and other cognitive functions disorders already in adolescence [ 13 , 14 ]. There are limited published data in regard to the relationship between SRBD and hypertension and behavioral and mental status in adolescence.…”

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confidence: 99%

Obstructive Sleep Apnea and Hypertension in Adolescents: Effect on Neurobehavioral and Cognitive Functioning

Мадаева

Polyakov

Kolesnikov

2016

Canadian Respiratory Journal

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Background. There are limited published data in regard to the relationship between obstructive sleep apnea (OSA) and hypertension and neurobehavioral and mental status in adolescence. The aim of our study was to evaluate neurobehavioral patterns and cognitive functions in adolescents with hypertension according to absence or presence of OSA. Methods. This was a retrospective cohort study completed at the Scientific Center for Family Health and Human Reproduction Problems. Participants included adolescents aged 14–17 years and referred for 24-hour ambulance blood pressure monitoring (ABPM) and polysomnographic (PSG) studies between 2007 and 2009, inclusive. Results. 18 hypertensive OSA (the 1st group) and 20 hypertensive non-OSA adolescents (the 2nd group) were included in the study. Significant changes of neurobehavioral functioning in OSA patients were shown. Cognitive abilities also were impaired. Verbal and visual memory indexes and attention index were 2.1 and 2.2 times lower, accordingly, in the 1st group than in the 2nd group (P < 0.05). Speech index was significantly 2.8 times lower in OSA patients than in non-OSA patients (P < 0.05). In hypertensive OSA adolescents more significant Spearman correlations between classic sleep parameters and cognitive measures were found compared to patients without OSA. Conclusions. These results suggest that OSA is closely associated with neurobehavioral and cognitive functioning in hypertensive adolescents.

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Role of alginate in the mechanism by which brown seaweed Saccharina japonica intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats

Maruyama

Segawa

Hashimoto

et al. 2021

Clinical and Experimental Hypertension

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Mental stress, hypertension and the baroreflex: what's new?

Cited by 5 publications

References 26 publications

Autonomic mechanisms underpinning the stress response in borderline hypertensive rats

Autonomic mechanisms underpinning the stress response in borderline hypertensive rats

Obstructive Sleep Apnea and Hypertension in Adolescents: Effect on Neurobehavioral and Cognitive Functioning

Role of alginate in the mechanism by which brown seaweed Saccharina japonica intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats

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