Role of alginate in the mechanism by which brown seaweed <i>Saccharina japonica</i> intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats

Maruyama, Saki; Segawa, Yukiko; Hashimoto, Hiroko; Kitamura, Saori; Kimura, M.; Osera, Tomoko; Kurihara, Nobutaka

doi:10.1080/10641963.2021.1991943

Cited by 4 publications

(9 citation statements)

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“…It has been reported that promoting sodium excretion is a potential mechanism for the effect of potassium alginate ingestion in suppressing the increase in BP. However, our previous study suggested that the promotion of fecal sodium excretion by SJ intake may not be one of the major mechanisms for attenuating hypertension [ 7 ]. This was because no significant correlation was observed between the intake amount of alginate contained in various seaweeds and the suppression of BP elevation.…”

Section: Discussionmentioning

confidence: 99%

“…This was because no significant correlation was observed between the intake amount of alginate contained in various seaweeds and the suppression of BP elevation. Additionally, fecal sodium excretion was found to be very small in comparison to urine excretion [ 7 ]. Recently, we proposed one of the mechanisms behind this, which is the restoration of intestinal barrier function in 2K1C rats, by having observed an alleviation in the decreases in gut tight junction protein expression and the number of goblet cells in 2K1C rats fed alginate [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on the BP-lowering effects of ingesting foods and their ingredients have reported angiotensin converting enzyme (ACE) inhibition due to ACE inhibitory peptides, as well as antioxidant effects [ 4 , 5 ]. Previous studies have observed that the intake of Saccharina japonica (SJ) suppressed the increase in BP in spontaneously hypertensive rats (SHRs) and 2-kidney, 1-clip renovascular hypertensive (2K1C) rats [ 6 , 7 ]. However, the mechanism behind the antihypertensive effect of SJ intake remains unclear, although it has been suggested to involve ACE inhibitory activity in vitro [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Saccharina japonica Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats

Harui,

Maruyama,

Segawa

et al. 2024

Microorganisms

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It was reported that the consumption of Saccharina japonica (SJ) lowers blood pressure (BP) in hypertensive rats. Hypertension is related to gut microbiota, and hypertensive patients develop dysbiosis. It was reported that the intake of dietary fiber and polysaccharides contained in SJ changes gut microbiota and increases short-chain fatty acids (SCFAs). The present study examined the effect of BP lowering by SJ in spontaneously hypertensive rats (SHRs) and observed changes in gut microbiota composition and SCFAs concentration. Male SHRs and Wistar Kyoto rats (WKYs) were fed a diet containing 5% SJ or a control diet for six weeks. We measured systolic BP (SBP) weekly, as well as mean arterial BP (MAP), the 16S rRNA gene, and SCFAs in the cecal contents at the end of the period. As a result, the intake of SJ significantly decreased SBP and MAP in SHRs. As well, it significantly changed the microbial diversity by altering the gut microbiota composition. Particularly, it increased the abundance of Bacteroides acidifaciens, which may be associated with the antihypertensive effect of SJ. Thus, SJ intake suppressed the increase in BP and altered the gut microbiota composition, although it did not significantly change the SCFAs concentration in the cecal contents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Saccharina japonica Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats

Harui,

Maruyama,

Segawa

et al. 2024

Microorganisms

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“…Diet is one of the many approaches to controlling hypertension. We demonstrated that the blood pressure (BP) of 2-kidney, 1-clip (2K1C) renovascular hypertensive rats fed a diet containing Saccharina japonica significantly decreased compared to that of 2K1C rats fed a control diet in our previous study [ 2 ]. Saccharina japonica contains sodium alginate, which has been reported to decrease BP in other hypertensive rats, as shown below.…”

Section: Introductionmentioning

confidence: 99%

Influence of Intestinal Barrier on Alleviating an Increase in Blood Pressure by Sodium Alginate Intake in 2-Kidney, 1-Clip Renovascular Hypertensive Rats

et al. 2023

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Sodium alginate (SALG) is a substance derived from brown seaweed that has been shown to reduce blood pressure (BP). However, its effects on renovascular hypertension caused by 2-kidney, 1-clip (2K1C) are not yet clear. Previous research suggests that hypertensive rats have increased intestinal permeability, and that SALG improves the gut barrier in inflammatory bowel disease mouse models. Therefore, the goal of this study was to determine whether the antihypertensive effects of SALG involve the intestinal barrier in 2K1C rats. Rats were fed either a 1.0% SALG diet or a control diet for six weeks after being subjected to 2K1C surgery or a sham operation. The systolic BP was measured weekly, and the mean arterial BP was measured at the end of the study. Intestinal samples were taken for analysis, and plasma lipopolysaccharide (LPS) levels were measured. The results showed that BP in 2K1C rats was significantly higher than in SHAM rats when fed CTL, but not when fed SALG. The gut barrier in 2K1C rats was improved by SALG intake. Plasma LPS levels also differed depending on the animal model and diet. In conclusion, dietary SALG may alleviate 2K1C renovascular hypertension by altering the gut barrier.

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“…Due to an increased global prevalence of health issues associated with metabolic syndrome, seaweeds are considered a potential resource of bioactive compounds that may prevent or treat several ailments including diabetes, high blood pressure and inflammation [ 5 , 6 , 7 , 8 , 9 ]. Brown seaweeds have now been investigated extensively for their alginate and polyphenol bioactivity, and potential application in pharmaceuticals [ 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

Purcell

Packer

Hayes

2022

Foods

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Seaweeds have a long history of use as both food and medicine, especially in Asian cultures. Moreover, there is growing interest in the use of seaweed ingredients and bioactive compounds in pharmaceutical and nutraceutical products. One ailment that seaweed bioactive compounds may impact is hypertension caused by the enzyme Angiotensin Converting Enzyme 1 (ACE-1; EC 3.4.15.1), found within the Renin-Angiotensin Aldosterone System (RAAS), which causes vasoconstriction of blood vessels, including veins and arteries. The aim of this paper is to generate bioactive peptide containing protein hydrolysates from the brown seaweed Laminaria digitata (Hudson) JV Lamouroux 1813. Proteins were extracted from this seaweed by disrupting the seaweed cell wall using a combination of carbohydrases and proteolytic enzymes. Bioactive peptide containing permeates were generated from L. digitata protein hydrolysates, and both hydrolysates and permeates were screened for their ability to inhibit the enzyme ACE-1. The protein content of the permeate fractions was found to be 23.87% compared to the untreated seaweed, which contained 15.08% protein using LECO analysis. Hydrolysis and filtration resulted in a “white” protein powder, and the protein content of this powder increased by 9% compared to the whole seaweed. The total amino acid (TAA) content of the L. digitata protein permeate was 53.65 g/100 g of the sample, and contains over 32% essential amino acids (EAA). Furthermore, the L. digitata permeate was found to inhibit the ACE-1 enzyme by 75% when compared to the commercial drug Captopril© when assayed at a concentration of 1 mg/mL. The inhibition of ACE-1 (the IC50 value) of 590 µg/mL for the L. digitata permeate compares well with Captopril©, which had 100% inhibition of ACE-1, with an IC50 value of 500 µg/mL. This study indicates that there is potential to develop protein powders with ACE-1 inhibitory bioactivities from the brown seaweed L. digitata using enzymatic hydrolysis as a cell disruption and protein extraction/hydrolysate generation procedure.

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Role of alginate in the mechanism by which brown seaweed Saccharina japonica intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats

Cited by 4 publications

References 51 publications

Effect of Saccharina japonica Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats

Effect of Saccharina japonica Intake on Blood Pressure and Gut Microbiota Composition in Spontaneously Hypertensive Rats

Influence of Intestinal Barrier on Alleviating an Increase in Blood Pressure by Sodium Alginate Intake in 2-Kidney, 1-Clip Renovascular Hypertensive Rats

Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

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