Mental Status of Children with Convulsive Disorders

Keith, Haddow M.; Ewert, Josephine C.; Green, Meredith W.; Gage, Robert P.

doi:10.1212/wnl.5.6.419

Cited by 48 publications

(17 citation statements)

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“…Therefore, he concluded that duration of seizures was less important than total number of seizures. In children as well, higher seizure frequency has been associated with lower intellectual ability (Keith et al, 1955;Farwell et al, 1985), but we did not note a significant relationship between IQ scores and total number of seizures. On multiple regression analysis, ?-value did not change when the total number of seizures was forced into the equation after status epilepticus and SES scores, whereas it changed by only 0.02 when the interaction variable duration of seizures multiplied by total number of seizures was forced into the equation as the third variable.…”

Section: Determinants Of Iqcontrasting

confidence: 80%

Determinants of IQ Profile in Children Generalized Epilepsy

et al. 1992

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To determine the IQ profile of children with epilepsy and the influence of various epilepsy-related variables on IQ scores, we studied 50 children with idiopathic generalized epilepsy of > 1-year duration, 25 of their siblings, and 30 healthy controls. IQ assessments were made with Malin's Indian modification of the Wechsler Intelligence Scale for Children. The mean +/- SD IQ scores of children with epilepsy (85.6 +/- 12) and their siblings (93.2 +/- 11) were significantly lower than those of the controls (101.6 +/- 9). The IQ scores of the children with epilepsy were also significantly lower than those of their siblings (p < 0.05). The IQ scores showed a significant correlation with socioeconomic status (SES) score (r = 0.33), a history of status epilepticus (r = -0.38), duration of seizure disorder (r = -0.31), and total number of seizures (r = -0.31). On multiple regression analysis, status epilepticus emerged as the most significant variable, accounting for 14% variance, followed by SES score (9% variance), duration of seizure disorder (6% variance), and sex of the child (5% variance). Genetic or environmental factors that probably lead to cognitive deficit in children with epilepsy and their siblings require further study.

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Section: Determinants Of Iqcontrasting

confidence: 80%

Determinants of IQ Profile in Children Generalized Epilepsy

et al. 1992

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“…have been recorded in about 40% cases. Dodrill et al 55 have reported emotional problems in 36-72% cases and vocational problems in 15-53% cases of adult epileptics across four countries namely Canada, Finland, Germany and U.S.A. Keith et al 56 found that the incidence of mental retardation with seizures beginning before six months was 65% and 12% in cases where seizures began between 7 to 15 years. So, the variations in the incidence of mental retardation and behavioral disorders may vary among populations due to difference in the age of onset of seizures.…”

Section: Discussionmentioning

confidence: 99%

Neuroepidemiology of Epilepsy in Northwest India

Pal

Sharma

Prabhakar

et al. 2010

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BackroundEpilepsy has a complex etiology characterised by recurring seizures.PurposeTo study clinical profile of epilepsy patients with reference to type of epilepsy in northwest India. No previous Indian study has reported relative incidence of various types of seizures with reference to type of epilepsy.MethodsData of 400 epilepsy patients (200 idiopathic and 200 symptomatic) was collected for their clinical characteristics. The classification of epilepsy into idiopathic and symptomatic types was done on the basis of findings of EEG, CT scan and MRI tests.ResultsThe age of onset of seizures was less than 15 years in only one third of the total patients. The number of non-vegetarians was higher in SE (68.5%) than IE (58%). The male to female ratio was significantly higher (1.33:1 in IE and 1.47:1 in SE). No difference was seen for place of residence (urban vs rural) patients with epilepsy (PWE). The majority of patients (58.5% of symptomatic and 52.8% idiopathic) though reported no triggering factors, yet many of them, when questioned, had held supernatural powers to be the cause of the disease. Sleep deprivation was reported as a major triggering factor by 28.5% of idiopathic epilepsy (IE) and 25% of symptomatic epilepsy (SE) patients. The incidence of mental retardation (1.25%) and behavioral disorders (7%) was found to be relatively low. Loss of memory was reported in 46% of IE and 43.5% of SE and poor scholastic performance in 23% of IE and 16.5% of SE. A positive history was recorded in 11% first-degree relatives and 4% second-degree relatives. Generalized seizures were more common in IE patients (67.5%), while partial seizures with and without secondary generalization (50.5%), and generalized seizures (49.5%) were equally common in SE. Conclusions: The study demonstrates differences in the type of seizures between idiopathic and symptomatic epilepsies and not other demographic, clinical and psycho-social traits. The males were found to have higher risk of epilepsy than females. The epidemiological characteristics of epileptics show variations across populations and also within population.

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“…But, as it was almost exclusively an electroencephalographic diagnosis, it failed to attract the attention of many clinicians. Laplane et al (13), Grey Walter et al (lo), Bridge (3), Livingston (17) and Keith (12) merely alluded to it in their publications. Sore1 (19) was the only one, in 1964, to resume the discussion of the above facts, which he proposed to bring under the heading of "severe myokinetic epilepsy of early childhood with slow spike-waves".…”

Section: Introductionmentioning

confidence: 99%

Childhood Epileptic Encephalopathy with Diffuse Slow Spike‐Waves (otherwise known as “Petit Mal Variant”) or Lennox Syndrome

Gastaut¹,

Roger²,

Soulayrol³

et al. 1966

Epilepsia

412

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RÉSUMÉ Les auteurs fournissent la description d'une variété très grave d‘épilepsie de l'enfant qui est rebelle à la thérapeutique et qui se caractérise par la triade symptomatique suivante: (1) crises épileptiques généralisées fréquentes, le plus souvent à type de crises toniques ou d'absences variantes de petit mal; (2) déficit intellectuel souvent grave; (3) décharges électroencéphalographiques intercritiques de pointes‐ondes lentes diffuses répétées de façon pseudo‐rythmique à 1.5–2.5 c/s. Un pareil tableau diffère peu de celui fourni par Lennox et col. il y a une quinzaine d'années. La contribution personnelle des auteurs se limite donc à préciser certaines données séméiologiques, cliniques aussi bien qu’électroencéphalographiques, et à fournir des considérations d'ordre diagnostique, étiologique, thérapeutique et physiopathogénique à propos de cette affection qu'ils proposent d'appeler: “Encéphalopathie épileptique de l'enfant avec pointes‐ondes lentes diffuses” ou “Syndrome de Lennox”.

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Mental Status of Children with Convulsive Disorders

Cited by 48 publications

References 0 publications

Determinants of IQ Profile in Children Generalized Epilepsy

Determinants of IQ Profile in Children Generalized Epilepsy

Neuroepidemiology of Epilepsy in Northwest India

Childhood Epileptic Encephalopathy with Diffuse Slow Spike‐Waves (otherwise known as “Petit Mal Variant”) or Lennox Syndrome

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