Mental Status Changes in an Alcohol Abuser Taking Valerian and Gingko Biloba

Chen, Daniel; Klesmer, Jordan; Giovanniello, Anthony; Katz, Jack L.

doi:10.1080/10550490252801666

Cited by 6 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among the cases of interaction with conventional drugs, nutrients or food/beverages, only four cases were considered sufficiently documented; they were cases of the following: (i) hypotension due to an interaction with Matricaria chamomilla and Melissa officinalis ; (ii) hand tremor, dizziness and muscular fatigue due to co‐administration with Passiflora incarnata and lorazepam ; (iii) change of mental status due to consumption together with alcohol and G. biloba ; and (iv) hepatitis due to interaction with Scutellaria lateriflor , containing alkylating agents, glycoside and volatile oils .…”

Section: Resultsmentioning

confidence: 99%

Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality

Lorenzo

Ceschi

Kupferschmidt

et al. 2015

Brit J Clinical Pharma

116

View full text Add to dashboard Cite

AIMSThe objective of this review was to collect available data on the following: (i) adverse effects observed in humans from the intake of plant food supplements or botanical preparations; (ii) the misidentification of poisonous plants; and (iii) interactions between plant food supplements/botanicals and conventional drugs or nutrients. METHODSPubMed/MEDLINE and Embase were searched from database inception to June 2014, using the terms 'adverse effect/s', 'poisoning/s', 'plant food supplement/s', 'misidentification/s' and 'interaction/s' in combination with the relevant plant name. All papers were critically evaluated according to the World Health Organization Guidelines for causality assessment. RESULTSData were obtained for 66 plants that are common ingredients of plant food supplements; of the 492 papers selected, 402 (81.7%) dealt with adverse effects directly associated with the botanical and 89 (18.1%) concerned interactions with conventional drugs. Only one case was associated with misidentification. Adverse effects were reported for 39 of the 66 botanical substances searched. Of the total references, 86.6% were associated with 14 plants, including Glycine max/soybean (19.3%), Glycyrrhiza glabra/liquorice (12.2%), Camellia sinensis/green tea ( 8.7%) and Ginkgo biloba/gingko (8.5%). CONCLUSIONSConsidering the length of time examined and the number of plants included in the review, it is remarkable that: (i) the adverse effects due to botanical ingredients were relatively infrequent, if assessed for causality; and (ii) the number of severe clinical reactions was very limited, but some fatal cases have been described. Data presented in this review were assessed for quality in order to make the results maximally useful for clinicians in identifying or excluding deleterious effects of botanicals.

show abstract

Section: Resultsmentioning

confidence: 99%

Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality

Lorenzo

Ceschi

Kupferschmidt

et al. 2015

Brit J Clinical Pharma

116

View full text Add to dashboard Cite

show abstract

“…There are some reports in the literature about concomitant ingestion of valerian and ethanol, but the interaction between these two substances has not been clearly demonstrated (Fugh-Berman & Cott 1999;Houghton 1999;Chen et al 2002;Hadley & Petry 2003). The additive effect observed by the co-administration of valerian and ethanol ( Figure 3E) was in agreement with the information available in the literature, and suggested that the sedative effect of valerian was through the GABA A receptors.…”

Section: Discussionmentioning

confidence: 99%

“…No adverse drug interactions involving valerian extracts have been reported in clinical trials, only in an unusual double-blind study in volunteers when alcohol failed to induce its predicted impairment of concentration when combined with a mixture of valepotriates from V. officinalis (Fugh-Berman & Cott 1999). There are some reports associated with the interaction between valerian and other medicinal herbs, prescribed drugs and alcohol (Chen et al 2002); however, these interactions have not been demonstrated completely. Animal in-vivo data have shown a prolongation of barbiturateinduced anaesthesia for some valerian species, including V. edulis (Oliva et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs andValeriana edulishydroalcoholic extract in mice*

Ugalde

Reza

González-Trujano

et al. 2005

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

It has been declared frequently that valerian may potentiate the effect of other central nervous system (CNS) depressant drugs, however there has been a lack of experimental data. We have evaluated the profile of the interactions between the ethanol extract of Valeriana edulis spp procera and six CNS depressant drugs using an exploratory model to test the sedative effect in mice. All the compounds tested showed a dose-dependent sedative effect with the following ED50 values: valerian 181.62, diazepam 1.21, ethanol 1938, pentobarbital 11.86, buspirone 1.04, haloperidol 0.41 and diphenhydramine 17.06 mg kg-1. An isobolographic analysis was used to evaluate the sedative interaction of the intraperitoneal co-administration of 1:1 fixed-ratio combination of equi-effective doses of valerian extract with each CNS depressant drug. The ED50 theoretical (Zadd) and experimental (Zexp) for each combination were: valerian+diazepam,Zadd=91.41 mg kg-1, Zexp=81.64 mg kg-1; valerian+ethanol, Zadd=1060.22 mg kg-1, Zexp=687.89 mg kg-1; valerian+pentobarbital, Zadd=96.74 mg kg-1, Zexp=151.83 mg kg-1; valerian+buspirone, Zadd=91.33 mg kg-1, Zexp=112.73 mg kg-1; valerian+haloperidol, Zadd=91.01 mg kg-1, Zexp=91.52 mg kg-1; valerian+diphenhydramine, Zadd=99.34 mg kg-1, Zexp=123.52 mg kg-1. Neither synergistic nor attenuate effects were found in any of the combinations evaluated. We concluded that the valerian extract did not potentiate the sedative effect of commonly prescribed CNS depressant drugs as was expected. The additive effect found through the isobolographic analysis suggested that the sedative effect of V. edulis resulted from the activation of common mechanisms of haloperidol, diazepam, buspirone, pentobarbital, diphenhydramine and ethanol.

show abstract

Toxicology and Drug Interactions of Nutraceuticals

Cope

2019

Nutraceuticals in Veterinary Medicine

View full text Add to dashboard Cite

Mental Status Changes in an Alcohol Abuser Taking Valerian and Gingko Biloba

Cited by 6 publications

References 4 publications

Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality

Adverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causality

Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs andValeriana edulishydroalcoholic extract in mice*

Toxicology and Drug Interactions of Nutraceuticals

Contact Info

Product

Resources

About