Mental nerve paraesthesia secondary to nicorandil-induced oral ulceration: a case report

Abstract

Nicorandil, used as a treatment for angina pectoris, continues to be prescribed in the UK. The association between nicorandil and oral ulceration is well documented. Nicorandil-induced oral ulceration characteristically presents as a persistent, large, deep ulcer that can have a great impact on quality of life. A 63-year-old female was referred to the oral medicine department with a non-healing ulcer and associated paraesthesia of the left lower lip. Her drug history included nicorandil 30 mg once daily. A provisional diagnosis was made of nicorandil-induced oral ulceration with associated paraesthesia, secondary to mental nerve involvement. Following liaison with cardiology, and cessation of nicorandil medication, the ulceration healed, and the patient reported improved sensation to the lower lip. CPD/Clinical Relevance: Nicorandil-induced oral ulceration should be considered in the differential diagnosis of oral ulceration.