Mental health symptoms in partial epilepsy

Butterbaugh, Grant; Rose, Marcy; Thomson, Jessica; Roques, B; Costa, Richard; Brinkmeyer, Mary Y.; Olejniczak, Piotr; Fisch, Bruce J.; Carey, Michael E.

doi:10.1016/j.acn.2004.12.007

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…Higher values represent more severe symptoms. Using criteria suggested by Derogatis (1994) and implemented in prior studies (Butterbaugh, Rose, Thomson, 2005), T-scores ≥63 for each dimension and index score were interpreted as representing indicate clinically significant symptomatology. In addition to the index scores, we examined two additional measures of overall psychiatric symptomatology (or “caseness”).…”

Section: Methodsmentioning

confidence: 99%

Clinically significant psychiatric symptoms among male carriers of the fragile X premutation, with and without FXTAS, and the mediating influence of executive functioning

Grigsby

Brega

Bennett

et al. 2016

The Clinical Neuropsychologist

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Objectives To clarify the neuropsychiatric phenotype of fragile X-associated tremor/ataxia syndrome (FXTAS), and assess the extent to which it is mediated by the dysexecutive syndrome that is a major feature of the disorder. Methods We examined the prevalence of clinically meaningful psychiatric symptoms among male carriers of the fragile X premutation, with and without FXTAS, in comparison with men with a normal allele. Measures included the Neuropsychiatric Inventory (NPI), Symptom Checklist-90-R (SCL-90-R), and the Behavioral Dyscontrol Scale (BDS), a measure of executive functioning. Between-group differences were evaluated using logistic regression, followed by a mediation analysis with ordinary least squares regression to assess the contribution of dysexecutive syndrome to the observed psychiatric domains. Results Men with FXTAS showed higher rates of clinically significant symptoms overall and in specific domains: somatization, obsessive-compulsive, depression, anxiety, psychoticism, agitation/aggression, apathy/indifference, irritability, and nighttime behavior problems. Post hoc analyses suggested that findings of psychoticism among men with FXTAS may be associated with participants’ accurate acknowledgement of cognitive and physical dysfunction, rather than reflecting psychosis. Asymptomatic carriers showed no evidence of clinically significant psychiatric symptoms, but when all carriers were compared with men having a normal FMR1 allele, executive function deficits were found to mediate scores in several domains on both NPI and SCL-90-R. Conclusions Building on prior research, the results provide evidence that the psychiatric phenotype for men includes clinically meaningful depression, hostility, and irritability, in association with behavioral and attentional disinhibition. It is likely that these problems reflect the effects of impaired executive functioning.

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Section: Methodsmentioning

confidence: 99%

Clinically significant psychiatric symptoms among male carriers of the fragile X premutation, with and without FXTAS, and the mediating influence of executive functioning

Grigsby

Brega

Bennett

et al. 2016

The Clinical Neuropsychologist

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“…Psychobehavioral problems frequently impair the health of patients with epilepsy (PWE; Fisher et al, 2000;Jehi et al, 2011;Mohammed et al, 2012). Depression, anxiety, obsessive-compulsive symptoms, psychosis, stigma, poor self-esteem, and coping difficulties were reported in 6-88% of PWE (Gramstad et al, 2001;Suurmeijer et al, 2001;Jones et al, 2003;Butterbaugh et al, 2005;Giovagnoli et al, 2006), showing a significant impact on quality of life (QoL; Fisher et al, 2000;Hermann et al, 2000;Tracy et al, 2007;Gois et al, 2011). Attention and memory deficits also proved to impair psychosocial adjustment (Shehata et al, 2009;Gois et al, 2011), but they did not predict QoL (Gois et al, 2011).…”

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confidence: 99%

Theory of mind and epilepsy: What clinical implications?

et al. 2013

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Summary Purpose Epilepsy can impair theory of mind (ToM), but the clinical significance of such a deficit is unknown. This study evaluated the influence of selective ToM deficits on self‐appraisal, coping, and quality of life (QoL) in patients with focal epilepsy. Methods Data were collected from 66 patients with temporal or frontal lobe epilepsy, and from 42 healthy controls. The Faux Pas Task (FPT), Multiple Ability Self‐report Questionnaire (MASQ), Coping Responses Inventory‐Adult (CRI‐Adult), and World Health Organization QoL 100 (WHOQoL 100) evaluated ToM, self‐rated cognitive abilities, coping to stressful events, and QoL. Different tests and inventories assessed other cognitive functions, depression, and anxiety. Key Findings Patients were impaired in the recognition and comprehension of social faux pas. The FPT scores contributed to predict the MASQ, CRI‐Adult, and WHOQoL overall scores; the comprehension of others' mental states and interactions score exerted a prominent influence. Significance In patients with focal epilepsy, selective ToM deficits may have clinical implications, with specific influence on self‐appraisal, coping, and overall QoL. ToM evaluation may contribute in explaining some psychobehavioral difficulties and to plan nonpharmacological treatment.

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“…Suicide risk is elevated in people with epilepsy and in older adults [ 114,115 ] , occurring more frequently in patients with chronic long-lasting epilepsy and medical and psychiatric comorbidities. Other disabling mental health symptoms also are common among people with epilepsy [ 116 ] . More research is needed to understand QOL issues and the causes and consequences of depression and other psychiatric disorders in geriatric epilepsy [ 12 ] .…”

Section: Quality Of Life and Moodmentioning

confidence: 99%

Epilepsy and Aging

Bell

Giovagnoli

2012

Handbook on the Neuropsychology of Aging and Dementia

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Epilepsy is the third most common neurological disorder of old age and a substantial public health problem. As the elderly population rises, the elderly will account for a large percentage of all new-onset seizures. However, while the study of epilepsy in adults in general has led to major advances in neuropsychology, epilepsy in the aged has been one of the more neglected areas within the fi eld. Geriatric epilepsy is now an emerging fi eld for all health-care practitioners, including neuropsychologists. Patient management requires assessment and treatment of cognitive and functional impairment and psychological issues. A thorough assessment of cognitive function is essential in discriminating epilepsy from classic progressive dementias and for assessing functioning prior to treatments for seizures once they are diagnosed. Neuropsychological assessment plays an important role to characterize cognitive impairments, reveal preserved abilities, help monitor medication treatment, track for coexistence of MCI or dementia, and assess for emotional distress.

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Mental health symptoms in partial epilepsy

Cited by 13 publications

References 16 publications

Clinically significant psychiatric symptoms among male carriers of the fragile X premutation, with and without FXTAS, and the mediating influence of executive functioning

Clinically significant psychiatric symptoms among male carriers of the fragile X premutation, with and without FXTAS, and the mediating influence of executive functioning

Theory of mind and epilepsy: What clinical implications?

Epilepsy and Aging

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