Mental Fatigue; A Common Long Term Consequence After a Brain Injury

Johansson, Birgitta; Rönnbäck, Lars

doi:10.5772/27042

Cited by 13 publications

(14 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, cognitive functions such as complex selective attention and information processing speed appear to be associated with mental fatigue. Subjects on sick leave due to mental fatigue after a mild TBI diverged from healthy controls in displaying a higher degree of mental fatigue and decreased information processing speed .…”

Section: Introductionmentioning

confidence: 92%

Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic brain injury

Johansson

Carlsson

et al. 2012

Acta Neuropsychiatr.

Self Cite

View full text Add to dashboard Cite

Objective: Mental fatigue occurring after a stroke or traumatic brain injury (TBI) often results in difficulties returning to work and pursuing social activities. No effective treatment of this condition is available today. In this study, we have tested a novel pharmacological strategy using the monoaminergic stabiliser (−)-OSU6162.Methods: (−)-OSU6162 was given orally for 4 weeks in doses increasing from 15 to 45 mg b.i.d. to 12 patients suffering from mental fatigue, following upon stroke (n=6) or TBI (n=6). (−)-OSU6162 was compared with placebo using a double-blind, randomised cross-over design. Patients included were well rehabilitated physically with no gross impairment in cognitive functions other than those related to the mental fatigue.Results: (−)-OSU6162 caused a remarkable improvement in mental stamina, as evaluated by a self-assessment scale on mental fatigue. Statistical significance was reached on the primary endpoint (Mental Fatigue Scale). There was a trend towards improvement in the secondary endpoints processing speed and attention. Principal component analysis showed an overall positive treatment effect in 7 of 12 patients. Beneficial responses were seen already during the first few days of active drug treatment. Increasing dosage caused no further improvement. Adverse reactions consisted of short-lasting mild nausea and attenuated appetite. These side effects disappeared upon dose reduction.Conclusion: The monoaminergic stabiliser (−)-OSU6162 offers promise as a candidate for treatment of mental fatigue after a stroke or TBI.

show abstract

Section: Introductionmentioning

confidence: 92%

Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic brain injury

Johansson

Carlsson

et al. 2012

Acta Neuropsychiatr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other symptoms, such as irritability, emotional instability and headache, which are common in association with the mental fatigue, further impair social interactions [9,10]. This mental fatigue is defined within the diagnosis 'Post-traumatic brain injury/postconcussion syndrome' (ICD10 F07.2).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dosage, safety and effects of methylphenidate on post-traumatic brain injury symptoms with a focus on mental fatigue and pain

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Traumatic brain injury (TBI) may cause long‐lasting physical, cognitive, and emotional impairments even irrespective of the severity of the TBI . Common long‐lasting symptoms include fatigue, concentration and memory problems, sensitivity to sound, light, and stress, irritability, emotional instability, and headache . As a consequence, social dysfunction including inability to work, along with health and economic impacts for the patients and society, emerges.…”

Section: Introductionmentioning

confidence: 99%

Long-term treatment with methylphenidate for fatigue after traumatic brain injury

et al. 2016

View full text Add to dashboard Cite

show abstract

Mental Fatigue; A Common Long Term Consequence After a Brain Injury

Cited by 13 publications

References 40 publications

Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic brain injury

Placebo-controlled cross-over study of the monoaminergic stabiliser (−)-OSU6162 in mental fatigue following stroke or traumatic brain injury

Evaluation of dosage, safety and effects of methylphenidate on post-traumatic brain injury symptoms with a focus on mental fatigue and pain

Long-term treatment with methylphenidate for fatigue after traumatic brain injury

Contact Info

Product

Resources

About