Long-term treatment with methylphenidate for fatigue after traumatic brain injury

Johansson, Birgitta; Wentzel, Anna-Pia; Andréll, Paulin; Rönnbäck, Lars; Mannheimer, Clas

doi:10.1111/ane.12587

Cited by 45 publications

(42 citation statements)

References 28 publications

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“…It found that methylphenidate reduces mental fatigue and improves cognitive functions with long-term methylphenidate treatment. [30] Although this study did not involve any type of control intervention, [30] its finding is consistent with the present study in showing that methylphenidate can reduce mental fatigue and improve cognitive outcomes in patients with TBI. Another reported study with a small sample size investigated the effects of methylphenidate and sertraline compared with placebo on various neuropsychiatric sequelae associated with TBI.…”

Section: Discussionsupporting

confidence: 88%

Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury

Zhang

Wang²

2017

Medicine

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Background:This study aimed to evaluate the effect of methylphenidate for treating mental sequelae after traumatic brain injury (TBI).Methods:Thirty-six patients with TBI were randomly divided into the intervention group and placebo group. The participants in the intervention group received methylphenidate, while subjects in the placebo group were administered a placebo. This study was conducted from January 2014 to December 2016. The outcome measurements included Mental Fatigue Scale, Choice Reaction Time, Compensatory Tracking Task, Mental Arithmetic Test, Digit Symbol Substitution Test, Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), and Hamilton Rating Scale for Depression. In addition, safety was also recorded and assessed.Results:A total of 33 subjects completed the study. Methylphenidate showed greater efficacy than placebo, with decreased scores on the Mental Fatigue Scale, Choice Reaction Time, and Compensatory Tracking Task in the intervention group compared to the placebo group (P < .01, respectively). Furthermore, increased scores on the Mental Arithmetic Test, Digit Symbol Substitution Test, and MMSE in the intervention group, compared to those in the placebo group (P < .01 respectively), were observed. In addition, a significant difference in the scores on the BDI (P = .04) and Hamilton Rating Scale for Depression (P = .005) was observed between the 2 groups. The safety at the end of the 30 week-treatment was similar between the 2 groups (P > .05).Conclusion:The results of this study demonstrated that methylphenidate could effectively improve mental fatigue and cognitive functions in patients with TBI.

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Section: Discussionsupporting

confidence: 88%

Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury

Zhang

Wang²

2017

Medicine

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“…Our research group have found fatigue after TBI to be alleviated but not cured. This has been demonstrated in pharmacological studies with both methylphenidate (36,37) and a dopamine stabilizer OSU6162 (38), and also after a mindfulness intervention with the Mindfulness-Based Stress Reduction programme (MBSR) (39,40). However, a greater knowledge of the pathophysiological mechanisms underlying fatigue is needed as well as further information regarding the risk factors.…”

Section: Discussionmentioning

confidence: 99%

Long-term mental fatigue after traumatic brain injury and impact on employment status

Palm

Rönnbäck²,

Johansson³

2017

J Rehabil Med

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Objective: Long-term mental fatigue following traumatic brain injury is endorsed as one of the most distressing symptoms, interfering considerably with return to work and social life. The objective of this cross-sectional study was to estimate the prevalence of long-term mental fatigue after traumatic brain injury and to evaluate its association with employment status. Methods: All patients (age range 19-65 years) diagnosed with traumatic brain injury irrespective of severity at Kungälv Hospital, Kungälv, Sweden, over a period of 5 years (n = 613) were invited by post to respond to questions about their injury, employment status and complete a questionnaire about mental fatigue, the Mental Fatigue Scale (MFS). Results: A response rate of 38% was achieved. Among respondents, 39% scored above the MFS cutoff of 10.5. Higher MFS scores were associated with decreased employment status (p < 0.001). Rating on the MFS was higher for women, for those with a longer initial duration of acute post-traumatic brain injury symptoms, and for those who had previously experienced a traumatic brain injury. No association was found between mental fatigue and age, severity of injury, or time since injury. Conclusion: Long-term mental fatigue was frequent among people who had experienced a traumatic brain injury, and a higher rating on the MFS was associated with decreased employment status.

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“…aSAH occurs at a relatively young age and it is important to detect mental fatigue so that a patient may be able to return to work and other social activities. The rehabilitation needs to include education on how to use coping strategies, as well as offering and evaluating pharmacological treatment in order to perceive the highest possible quality of life (Johansson, Wentzel, Andréll, Rönnbäck, & Mannheimer, ). In this study, we found a correlation between the GOSE and the MFS scale.…”

Section: Discussionmentioning

confidence: 99%

Mental fatigue assessment may add information after aneurysmal subarachnoid hemorrhage

et al. 2019

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Background Mental fatigue, as part of cognitive dysfunction, has been reported to be common after subarachnoid hemorrhage and it significantly affects quality of life. Aims of the Study The aim of this study was to assess mental fatigue one year after an aneurysmal subarachnoid hemorrhage and to correlate the degree of mental fatigue to functional outcome assessed with the Extended Glasgow Outcome Scale (GOSE). Methods One year after an aneurysmal subarachnoid hemorrhage, the GOSE was assessed and a questionnaire for self‐assessment of mental fatigue, the Mental Fatigue Scale, was distributed to all included patients. The maximum score is 42 and a score of ≥10.5 indicates mental fatigue. Results All patients with GOSE 8, indicating full recovery, had a mental fatigue score of <10.5. A linear correlation between the GOSE and the mental fatigue score was observed (p < 0.0001). Conclusions Patients with a favorable outcome and GOSE 5–7 could benefit from the assessments of mental fatigue in order to receive satisfactory rehabilitation.

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Long-term treatment with methylphenidate for fatigue after traumatic brain injury

Cited by 45 publications

References 28 publications

Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury

Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury

Long-term mental fatigue after traumatic brain injury and impact on employment status

Mental fatigue assessment may add information after aneurysmal subarachnoid hemorrhage

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