Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence

Allen, Sharon; Allen, Alicia M.; Kotlyar, Michael; Lunos, Scott; Al’Absi, Mustafa; Hatsukami, Dorothy K.

doi:10.1093/ntr/nts236

Cited by 17 publications

(17 citation statements)

References 38 publications

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“…These data are similar to our recent observations, of women without depressive symptoms, revealing that the follicular phase, as compared with the luteal phase, was associated with a more pronounced physiological response to nicotine nasal spray during short-term smoking abstinence (e.g. greater diastolic blood pressure and heart rate, and higher maximum concentrations of nicotine) [59]. Similarly, Schiller et al [60•] observed that lower PE ratios were associated with increased smoking.…”

Section: Sex Hormonessupporting

confidence: 91%

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

2014

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Smoking is still the leading cause of premature morbidity and mortality. This paper examines new research on gender differences and the epidemiology of smoking, smoking-related morbidity and mortality, and factors that affect smoking cessation. The rate of decline in the prevalence of smoking has been slowing, especially among adolescent girls. New research suggests that, compared with men, women may be more susceptible to smoking-related morbidity and mortality. Gender-related barriers to smoking cessation include weight gain, sex hormones, and mood. Furthermore, the sensory aspects of smoking may have more of an effect on smoking treatment for women than for men. We discuss new studies that examine smoking-cessation interventions that may be particularly beneficial for women, including exercise (as an adjunct intervention), very low nicotine content cigarettes, and a variety of pharmacotherapy. Further research is needed to identify and target the gender-specific needs of smokers.

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Section: Sex Hormonessupporting

confidence: 91%

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

2014

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“…We highlight research methodology of the S. Allen et al [45]•• study because the controlled cross-over design has several strengths, including limiting confounds, multimodal assessments, between- and within-subject data, and information on both follicular and luteal phases within the same participant. As such, several publications have resulted from using this strong research approach [46–49, 26, 45, 50, 51]. …”

Section: Acute Smoking Abstinence Studiesmentioning

confidence: 99%

Ovarian Hormones, Menstrual Cycle Phase, and Smoking: a Review with Recommendations for Future Studies

2016

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Cigarette smoking continues to be the leading cause of preventable morbidity and mortality. Similar to other addictive substances, the prevalence of cigarette smoking is greater among men than women, yet women are less successful at quitting smoking. Preclinical and clinical research suggests that ovarian hormones (i.e., estradiol and progesterone), which fluctuate over the course of the menstrual cycle, may contribute to these sex differences. Specifically, research suggests that progesterone may protect against cigarette smoking and nicotine addiction; whereas estradiol may underlie enhanced vulnerability. In this review, we discuss new research on ovarian hormone and menstrual cycle phase effects on smoking-related responses and behavior in women, including studies examining neural responses to smoking cues, hormonal influences on medication-assisted smoking cessation, and acute smoking abstinence. We highlight innovative studies with strong research methodology and provide suggestions for future research that may allow evidence-based knowledge for immediate translation to the clinic to guide novel, hormonally-informed treatment strategies. Thus, rigorous scientific study holds the potential to reduce relapse rates, thus improving the health and saving the lives of the many thousands of women who unfortunately do not respond to current treatments.

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“…Studies have looked at links between depression and smoking (Weinberger & McKee, 2011; Wewers, et al, 2012), hormonal fluctuations and smoking (Allen, et al, 2008; Lynch, & Sofuoflu, 2010; Sofuoglu, Mouratidis, & Mooney, 2010) and hormonal fluctuations and depression (Allen, et al, 1999; Allen, et al, 2012; & Harvey, et al, 2009), but none have addressed the potential synergistic effects of sex hormones (as measured by the proxy menstrual phase) and depressive symptoms during smoking cessation. Given that the vast majority of premenopausal women relapse within the first few days of a quit attempt (Allen, et al, 2008), the present study was designed to examine the risk factors for smoking relapse within the first four days of abstinence.…”

Section: Introductionmentioning

confidence: 99%

Smoking- and menstrual-related symptomatology during short-term smoking abstinence by menstrual phase and depressive symptoms

Allen

Tosun

et al. 2014

Addictive Behaviors

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Menstrual phase and depressive symptoms are known to minimize quit attempts in women. Therefore, the influence of these factors on smoking- and menstrual-related symptomatology during acute smoking cessation was investigated in a controlled cross-over lab-study. Participants (n=147) completed two six-day testing weeks during their menstrual cycle with testing order randomly assigned (follicular vs. luteal). The testing week consisted of two days of ad libitum smoking followed by four days of biochemically verified smoking abstinence. Daily symptomatology measures were collected. Out of the 11 total symptoms investigated, six were significantly associated with menstrual phase and nine were significantly associated with level of depressive symptoms. Two significant interactions were noted indicating that there may be a stronger association between depressive symptoms with negative affect and premenstrual pain during follicular phase compared to luteal phase. Overall, these observations suggest that during acute smoking abstinence in premenopausal smokers, there is an association between depressive symptoms and symptomatology whereas menstrual phase appears to have less of an effect. Further study is needed to determine the effect of these observations on smoking cessation outcomes, as well as to define the mechanism of menstrual phase and depressive symptoms on smoking-related symptomatology.

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Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence

Cited by 17 publications

References 38 publications

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

Women and Smoking: The Effect of Gender on the Epidemiology, Health Effects, and Cessation of Smoking

Ovarian Hormones, Menstrual Cycle Phase, and Smoking: a Review with Recommendations for Future Studies

Smoking- and menstrual-related symptomatology during short-term smoking abstinence by menstrual phase and depressive symptoms

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