Menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells

Bozorgmehr, Mahmood; Moazzeni, Seyed Mohammad; Salehnia, Mojdeh; Sheikhian, Ali; Nikoo, Shohreh; Zarnani, Amir‐Hassan

doi:10.1016/j.imlet.2014.10.005

Cited by 35 publications

(21 citation statements)

References 34 publications

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“…MenSC have a weaker and distinct in vitro effect on T cell proliferation compared to bmMSC (Aleahmad et al, 2018), possibly similar to the lesser characterized eMSC responses. As expected, MenSC also have an impact on the innate immune system, including human blood monocyte-derived dendritic cells (MoDCs) ( Table 4) (Bozorgmehr et al, 2014), NK cells and tissue macrophages. MenSC co-cultured with human monocytes interfered with MoDC differentiation at the phenotypic level.…”

Section: In Vitro Immunomodulatory Properties Of Menscsupporting

confidence: 71%

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Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Bozorgmehr

Gurung

Darzi

et al. 2020

Front. Cell Dev. Biol.

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Section: In Vitro Immunomodulatory Properties Of Menscsupporting

confidence: 71%

“…As expected, MenSC also have an impact on the innate immune system, including human blood monocyte-derived dendritic cells (MoDCs) ( Table 4 ) ( Bozorgmehr et al, 2014 ), NK cells and tissue macrophages. MenSC co-cultured with human monocytes interfered with MoDC differentiation at the phenotypic level.…”

Section: Immunomodulatory Properties Of Emsc and Menscsupporting

confidence: 62%

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Bozorgmehr

Gurung

Darzi

et al. 2020

Front. Cell Dev. Biol.

Self Cite

135

116

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show abstract

“…Some of their practical advantages include the noninvasive method of their isolation, their easy expansion, high proliferative rate, potent angiogenic effect, migratory properties and hematopoietic stem cell support reported both in vitro and in vivo . However, although the inhibitory effect of MenSCs on dendritic cells maturation has been reported their immunosuppressive potential has not yet been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

et al. 2015

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Recently, a noninvasive and highly proliferative stem cell population from menstrual blood called MenSCs has been identified. Despite their use in clinical studies, their immunomodulatory properties have not yet been investigated. In this context, we studied the immunosuppressive properties of MenSCs in comparison with the well-characterized bone marrow derived-MSCs (BM-MSCs). Using an in vitro proliferation assays, we showed that MenSCs displayed a lower suppressive effect on peripheral blood mononuclear cells and in particular on the proinflammatory CD4 1 IFN-c1 and CD81 IFNc 1 cells than BM-MSCs. Moreover, compared to BM-MSCs, MenSCs activated with IFN-c and IL-1b produced lower amounts of immunosuppressive factors such as IDO, PDL-1, PGE2, and Activin A and exhibited a substantial lower expression level of IFN-c receptor subunits. In the collagen induced arthritis model, while BM-MSCs administration resulted in a potent therapeutic effect associated with a significant decrease of proinflammatory T cell frequency in the lymph nodes, MenSCs injection did not. In contrast, in the xeno-GVHD model, only MenSCs administration significantly increased the survival of mice. This beneficial effect mediated by MenSCs was associated with a higher capacity to migrate into the intestine and liver and not to their anti-inflammatory capacities. All together our results demonstrate for the first time that the therapeutic potential of MSC in the experimental xeno-GVHD model is independent of their immunosuppressive properties. These findings should be taken into consideration for the development of safe and effective cell therapies. STEM CELLS 2016;34:456-469 SIGNIFICANCE STATEMENTIn the present study we report for the first time the immunosuppressive properties of MenSCs. We showed that they present lower immunosupressive properties compared to bone marrowMSCs, evidenced by lower expression of several immunomodulatory factors, and the absence of beneficial effect in experimental arthritis model. However, their therapeutic effect was maintained in the xeno-GVHD model, but this was independent on their antiinflammatory capacities. Since the use of MenSC has being proposed for several clinical trials the information provided here raises the alertness for evaluating carefully their potential side effects, a key prerequisite for the development of safe cell therapies.

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“…This effect was attributed to IL-6 and IL-10 production because the levels of these cytokines were increased in the culture medium. 68 Due to their immune suppressing properties, MSCs may be a good option for autoimmune diseases, such as systemic lupus erythaematosus, diabetes type I and multiple sclerosis. 69 However, the presence of MSCs with immune modulating characteristics must be taken into account in the tumour microenvironment because these cells may have important implications for tumour growth.…”

Section: Review Articlesmentioning

confidence: 99%

The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

2017

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Mesenchymal stem cells (MSCs) have been isolated from the endometrium of humans, mice, cows, pigs and ewes. Typically, these cells are detected in the deep regions of the endometrium, closer to the union with the myometrium. MSCs possess characteristics such as clonogenicity and multipotentiality since they can differentiate in vitro into adipogenic, chondrogenic and osteogenic lineages. These cells can be induced to differentiate in vitro not only into the mesodermal lineage but also into the endodermal and ectodermal lineages. Therefore, MSCs show a great regenerative capacity for various organs and tissues, including the endometrium. Some advantages of endometrial MSCs compared with other MSC sources are their immune modulating activity, their ease of obtainment, and the amount of sample that may be collected. The study of endometrial MSCs in domestic animals is a new and promising field because increasing our understanding of the physiology and biology of these cells may lead to a better understanding of the physiopathology of reproductive diseases, and the development of treatment methods for infertility problems. In other veterinary medicine fields, MSCs can be used for the treatment of autoimmune diseases, cardiac affections, musculoskeletal and articular lesions, muscle degeneration, type 1 diabetes, urinary tract diseases, neurodegenerative processes and tumours. Finally, MSCs are also an important clinical tool for tissue engineering and regenerative medicine. The aim of this review is to present an updated outlook of the knowledge regarding endometrial MSCs and their possible applications in veterinary medicine.

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Menstrual blood-derived stromal stem cells inhibit optimal generation and maturation of human monocyte-derived dendritic cells

Cited by 35 publications

References 34 publications

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application

The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases

The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

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