The escalating deforestation in the Amazon region poses a grave threat not only to biodiversity, but also to climate, ecosystems, and local and international communities. This paper addresses the issue of combating deforestation in the Brazilian Amazon in recent decades and proposes strategies to bring forest destruction to a halt. Although Brazil has made significant progress on this matter, there are still challenges to overcome in order to fully eradicate the practice of illegal deforestation in the region. Here, we aim to analyze the main initiatives that have been successful in reducing deforestation and identify opportunities to bring it to zero by the years 2030, 2040, and 2050. Our results suggest that actions to combat deforestation should depend on the land characteristics of the deforested areas, prioritizing the reduction in public lands, which are responsible for 51% of recent deforestation rates, followed by settlement areas and lastly by rural properties, mainly through command-and-control strategies (top-down), incentives for agroforestry reforestation and development of local bioeconomic chains.