Menopause is associated with bone loss, particularly at the distal radius, in black South African women: Findings from the Study of Women Entering and in Endocrine Transition (SWEET)

Breasail, Mícheál Ó; Gregson, Celia L; Norris, Shane A; Madanhire, Tafadzwa; Jaff, Nicole; Crowther, Nigel J; Micklesfield, Lisa K.; Ward, Kate

doi:10.1016/j.bone.2022.116543

Cited by 4 publications

(5 citation statements)

References 37 publications

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“…Foot fractures emerged as the most common, accounting for 35% of fractures, while hand fractures followed closely at 31%. Previous research suggests that distal fractures are predominantly prevalent in post-menopausal women [ 16 , 17 ]. This highlights a noteworthy frequency of fractures in the extremities, potentially interconnected with stability and fall-related factors.…”

Section: Discussionmentioning

confidence: 99%

The Relation Between Osteoporosis and Bone Fractures and Health-Related Quality of Life in Post-menopausal Saudi Women in the Jazan Region: A Cross-Sectional Study

El-Setouhy,

Khired,

Darraj

et al. 2024

Cureus

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Introduction: Osteoporosis is a significant health concern, often leading to fragility fractures and severely impacting the quality of life in post-menopausal women. Studies evaluating the effects of osteoporosis and resultant fractures on health-related quality of life (HRQoL) in Saudi women are lacking. This study aimed to assess the relationship between osteoporosis and fracture and physical, psychological, social, and environmental HRQoL domains in post-menopausal Saudi women. Methods: In this cross-sectional study conducted in Jazan, Saudi Arabia, 158 post-menopausal Saudi women completed HRQoL surveys using the validated Arabic WHOQOL-BREF questionnaire. Data on socioeconomics, comorbidities, and fracture history were gathered. Descriptive statistics delineated sample characteristics. Analysis of variance (ANOVA) and post-hoc tests identified differences in HRQoL across socioeconomic and clinical categories. Multivariate regression analyses determined factors independently related to HRQoL. Results: Of 158 women surveyed, 39% had a history of osteoporotic fracture. Foot (35%), hand (31%), and vertebral (10%) fractures were the most frequent. Women over 70 had significantly lower physical HRQoL than those aged 45-55 (p<0.001). Unemployed and lower-income women showed poorer HRQoL across domains (p<0.01). Vertebral and hand fractures were negatively related to physical and psychological health (p<0.05). Chronic diseases like hypertension and rheumatoid arthritis reduced HRQoL (p<0.01). In regression analyses, older age, vertebral fracture, physical inactivity, long-term hormone therapy, and unemployment emerged as determinants of poorer HRQoL (p<0.05). Conclusion: Osteoporosis and resultant fragility fractures, especially in vertebral and hand bones, led to substantial impairments in physical, social, psychological, and environmental HRQoL in Saudi women. Modifiable risk factors like physical inactivity and long-term hormone use also affected HRQoL. Targeted screening and multidomain interventions for disadvantaged women with osteoporosis are warranted to improve functioning and quality of life.

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Section: Discussionmentioning

confidence: 99%

The Relation Between Osteoporosis and Bone Fractures and Health-Related Quality of Life in Post-menopausal Saudi Women in the Jazan Region: A Cross-Sectional Study

El-Setouhy,

Khired,

Darraj

et al. 2024

Cureus

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“…Baseline data collection (2011–2015) recruited 1004 randomly selected caregivers of the Birth to Twenty Plus cohort. A randomly selected sub-sample of women aged 40–61 years were followed-up (January 2017 to August 2018) [ 26 ••, 28 ] The Hertfordshire Cohort Study (HCS), in the UK, a prospective, population-based study of the lifecourse origins of adult disease among community-dwelling men and women, recruited adults born in Hertfordshire, UK 1932–1939 [ 29 ] The Health, Aging and Body Composition Study (HealthABC) in the USA, with more than 7-year prospective cohort study, recruited Black and White Americans (age 68–89 years) at baseline (in 1997–1998) [ https://healthabc.nia.nih.gov/ ] [ 30 ] …”

Section: Studies and Methodologymentioning

confidence: 99%

Section: Studies and Methodologymentioning

confidence: 99%

Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA

Ward

Parsons

Madanhire

et al. 2023

Curr Osteoporos Rep

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Purpose To review the rising prevalence of osteopenia and osteoporosis in sub-Saharan Africa and the challenges this poses to governments and healthcare services. Using existing studies, we compare the prevalence of osteopenia and osteoporosis in men and women from sub-Saharan Africa to US and UK cohorts. Context-specific disparities in healthcare are discussed particularly the challenges in diagnosis and treatment of osteoporosis. Recent Findings There are few epidemiological data describing the burden of osteoporosis in sub-Saharan Africa. In the studies and cohorts presented here, osteoporosis prevalence varies by sex, country and area of residence, but is generally higher in African populations, than has previously been appreciated. Risk factors contributing to poorer bone health include HIV, malnutrition and “inflammaging.” Summary Reprioritization towards care of ageing populations is urgently required. Equitable access to implementable preventative strategies, diagnostic services, treatments and pathways of care for bone health (for example embedded within HIV services) need now to be recognized and addressed by policy makers.

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“…11,12 Several studies have proposed HIV and the menopause as being independent factors for low BMD because the prevalence of osteoporosis in postmenopausal women living with HIV (WLH) shows a significant variation (between 7% to 84% compared with 7% to 23% in uninfected 12 ). [13][14][15][16][17][18][19][20][21] Women living with HIV have lower BMD than noninfected women, which increases the risk of fracture in the hip, vertebral, and wrist bones. 8,9,[15][16][17] It is possible that modifiable risk factors, such as body mass index (BMI), smoking, physical activity, and others, may contribute to the reduction in bone mass in WLH.…”

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confidence: 99%

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

Leite-Silva,

Pinheiro,

Barbosa-Ferreira

et al. 2023

Menopause

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Objective The aim of this study was to assess the prevalence of low bone mass (osteopenia/osteoporosis), the factors associated with low bone mass, and the risk of fractures in Brazilian postmenopausal women living with HIV (WLH) in the Amazon region Methods This is a cohort study with a cross-sectional assessment at baseline conducted between March 2021 to August 2022 with 100 postmenopausal WLH undergoing antiretroviral therapy (ART) between 45 and 60 years of age and 100 age-matched HIV-negative women. Data on bone mineral density in the lumbar spine (LS) and femoral neck (FN) were collected using dual x-ray absorptiometry and the 10-year risk of hip and major osteoporotic fractures was assessed using the Fracture Risk Assessment tool (FRAX). Results The age of menopause onset occurred earlier in WLH (P < 0.001). No differences in prevalence of osteoporosis and osteopenia in LS and FN were observed except for a lower T score in FN in WLH (P = 0.039). The FRAX for major osteoporotic fracture and hip fracture were low in both groups, despite the mean of both FRAX scores was higher in WLH (P < 0.001). Multivariate analysis showed that years since menopause onset, higher body mass index and higher FRAX major osteoporotic fracture were associated with the WLH group, while a higher frequency of physical activity was registered in the HIV-negative group. Multivariate analysis also showed that in WLH, a lower T score in FN was associated with years since menopause onset and body mass index and that the number of years since menopause onset was associated with a lower T score in the LS and a higher score in the FRAX hip fracture. Conclusions Our findings show a high prevalence of low bone mass (osteopenia/osteoporosis) in Brazilian postmenopausal women from the Amazon region. Women living with HIV have higher FRAX scores than HIV-negative women and a lower T score in the FN.

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Menopause is associated with bone loss, particularly at the distal radius, in black South African women: Findings from the Study of Women Entering and in Endocrine Transition (SWEET)

Cited by 4 publications

References 37 publications

The Relation Between Osteoporosis and Bone Fractures and Health-Related Quality of Life in Post-menopausal Saudi Women in the Jazan Region: A Cross-Sectional Study

The Relation Between Osteoporosis and Bone Fractures and Health-Related Quality of Life in Post-menopausal Saudi Women in the Jazan Region: A Cross-Sectional Study

Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA

Bone mass, fracture risk, and associated factors in postmenopausal women living with HIV

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