Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA

Ward, Kate A; Parsons, Camille; Madanhire, Tafadzwa; Wade, Alisha; Fabian, June; Micklesfield, Lisa K.; Gregson, Celia L

doi:10.1007/s11914-023-00801-x

Cited by 5 publications

(1 citation statement)

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“… 9 The prevalence of osteoporosis and osteopenia in the aging population is significantly higher in women than men, with significant differences between various countries and races. 10 Different patterns of focal osteoporosis were observed in femoral neck and trochanteric fracture patients, showing the preferential locations in the proximal femur where cracks are expected to initiate during falls. Moreover, the same anatomical areas are at risk of rapid bone loss with ageing.…”

Section: Introductionmentioning

confidence: 99%

Mapping the Spatial Evolution of Proximal Femur Osteoporosis: A Retrospective Cross-Sectional Study Based on CT Scans

Bot,

Chirla,

Hozan

et al. 2024

IJGM

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Purpose The purpose of this study was to quantify the modifications occurring in osteoporosis at the level of the human proximal femur throughout the trabecular structure, along with the identification of certain anatomic regions preferentially affected by osteoporosis. Another goal was to map the evolution of the radiodensity of the trabecular bone as osteoporosis progresses to an advanced stage. Methods The study included CT scans (right femur) from 51 patients, out of which 40 had various degrees of osteoporosis, but no other local pathology. Ten regions of interest in two orthogonal slices have been identified and the differences in radiodensity as well as their evolution have been statistically analyzed in terms of relative and absolute changes. Results A detailed spatial map showing the evolution of osteoporosis was obtained. As osteoporosis evolved, the relative decrease in radiodensity was inversely correlated to the radiodensity of the healthy bone. In particular, the region covering the Ward triangle decreased the most, by an average 61–62% in osteopenia and 101–106% in advanced osteoporosis, while the principal compressive group was affected the least, showing a decrease by an average 14–15% in osteopenia and 29–32% in advanced osteoporosis. The absolute decrease in radiodensity was not correlated to the radiodensity of the healthy bone and was shifted to the inferior-posterior edge of the femur. Inside the femoral head, the upper region was affected the most in absolute terms, while the greater trochanter was less affected than the femoral neck. The maximum metaphyseal cortical bone density was unaffected by the progression of osteoporosis. Conclusion Significant differences were noticed in terms of the absolute and relative osteoporotic changes in radiodensity related to different anatomical regions of the human femoral bone. These differences become more pronounced as the disease progresses.

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Section: Introductionmentioning

confidence: 99%