Menopause does not affect blood pressure and risk profile, and menopausal women do not become similar to men

Casíglia, Edoardo; Tikhonoff, Valérie; Caffi, Sandro; Bascelli, Anna; Schiavon, Laura; Guidotti, Federica; Saugo, Mario; Giacomazzo, Martina; Martini, Bortolo; Mazza, Alberto; D’Este, D; Pessina, Achille C.

doi:10.1097/hjh.0b013e32830bfdd9

Cited by 83 publications

(49 citation statements)

References 74 publications

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“…Casiglia et al 35 , in a study with 9,364 Italian men and women found results that were similar to the ones of this study: higher prevalence of MS components among postmenopausal women, but this difference disappeared after adjustment for age. In the study conclusion, the authors mentioned that "the cardiovascular effects usually attributed to menopause seem to be merely a consequence of the older age of menopausal women 35 .…”

Section: Figueiredo Neto Et Al Metabolic Syndrome and Menopausesupporting

confidence: 72%

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Síndrome metabólica e menopausa: estudo transversal em ambulatório de ginecologia

Neto¹,

Figueredo²,

Barbosa³

et al. 2010

Arq. Bras. Cardiol.

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Section: Figueiredo Neto Et Al Metabolic Syndrome and Menopausesupporting

confidence: 72%

“…In the study conclusion, the authors mentioned that "the cardiovascular effects usually attributed to menopause seem to be merely a consequence of the older age of menopausal women 35 . "…”

Section: Figueiredo Neto Et Al Metabolic Syndrome and Menopausementioning

confidence: 99%

Síndrome metabólica e menopausa: estudo transversal em ambulatório de ginecologia

Neto¹,

Figueredo²,

Barbosa³

et al. 2010

Arq. Bras. Cardiol.

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“…The gender differences may be related to the faster transport of lipids in the bloodstream of women compared with men in the blood stream, earlier age-graded serum cholesterol changes in women, and higher concentrations of cholesterol in elderly women than men (53)(54)(55). However, our results underscored the importance of keeping cholesterol concentration within the high normal range, although a longitudinal follow-up is needed to determine whether higher cholesterol prevents later life cognitive impairment in both men and women.…”

Section: Discussionmentioning

confidence: 99%

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Yin

Chei

et al. 2016

The Journal of nutrition, health and aging

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Objectives-The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly.Design-A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models. Conflict of interestThe authors declare that there are no conflicts of interests. Ethical standardsThe authors declare that all the experiments of this study complied with the current laws of China in which they were performed. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptSetting-Community-based setting in eight longevity areas in China.Subjects-A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study. Measurements-Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score≤23.Results-There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62-0.84) for TC, 0.81(0.70-0.94) for LDL-C and 0.81(0.70-0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years).Conclusions-These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.

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“…20 In older women, menopause might contribute to the continuing rise in SBP, although it is difficult to differentiate the effects of aging from those of estrogen deprivation. 21,22 Single regression co-efficients (b ± s.e.) describe the cross-sectional associations of blood pressure with age.…”

Section: Discussionmentioning

confidence: 99%

Age dependency of peripheral and central systolic blood pressures: cross-sectional and longitudinal observations in a Chinese population

Staessen

Sheng

et al. 2011

Hypertens Res

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Few studies have described the age-related changes in both peripheral and central systolic blood pressures (SBPs) in populations. We addressed this issue in 1066 women and 978 men, all untreated (mean age, 45.1 years; 27.2% hypertensive) and randomly selected from a Chinese population, of whom 369 and 330 underwent a repeat examination after 3.6 years (median). In cross-sectional analyses, central SBP increased more with age than peripheral SBP in women below age 50 (1.21 vs. 1.01 mm Hg per year; Po0.001) and in men below age 60 (0.73 vs. 0.48 mm Hg per year; Po0.001), whereas in older women (0.64 vs. 0.58 mm Hg per year; P¼0.27) and older men (0.45 vs. 0.44 mm Hg per year; P¼0.79), the slopes of central and peripheral SBPs on age were similar. Compared with men, women had steeper (Po0.001) age-related increases in peripheral and central SBPs. Systolic augmentation pressure increased with age, but this increase was substantially smaller (Po0.0001) for peripheral than central augmentation (women, 0.086 vs. 0.45 mm Hg per year; men, 0.083 vs. 0.39 mm Hg per year). In multivariable-adjusted regression, age contributed X89.7% of the explained variance in peripheral and central SBPs. In longitudinal analyses, the annual percentage increases from baseline to follow-up in peripheral and central SBP were similar (PX0.76) in both women (2.14% vs. 2.16 % per year) and men (1.33% vs. 1.34 % per year; P-values for sex difference p0.044). In conclusion, in younger subjects assessed cross-sectionally, the age-related increase was larger for central than peripheral SBP, whereas the corresponding cross-sectional estimates in older subjects and the longitudinal estimates in all subjects showed similar age-related increases in central and peripheral SBP.

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Menopause does not affect blood pressure and risk profile, and menopausal women do not become similar to men

Abstract: The cardiovascular effects usually attributed to menopause seem to be a mere consequence of the older age of menopausal women.

Cited by 83 publications

References 74 publications

Síndrome metabólica e menopausa: estudo transversal em ambulatório de ginecologia

Síndrome metabólica e menopausa: estudo transversal em ambulatório de ginecologia

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Age dependency of peripheral and central systolic blood pressures: cross-sectional and longitudinal observations in a Chinese population

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