Menopause and metabolic syndrome in Tunisian women

Abstract

Objectives. This study aimed to evaluate the effect of menopausal status on the risk of metabolic syndrome (MetS) in Tunisian women. Methods. We analyzed a total of 2680 women aged between 35 and 70 years. Blood pressure, anthropometric indices, fasting glucose, and lipid profile were measured. The MetS was assessed by the modified NCEP-ATPIII definition. Results. The mean values of waist circumference, blood pressure, plasma lipids, and fasting glucose were significantly higher in postmenopausal than in premenopausal women, a difference that was no longer present when adjusting for age. Except for hypertriglyceridaemia, the frequency of central obesity, hyperglycemia, high blood pressure, and high total cholesterol was significantly higher in postmenopausal than in premenopausal women. After adjusting for age, the significance persisted only for hyperglycemia. The overall prevalence of MetS was 35.9%, higher in postmenopausal (45.7% versus 25.6%) than in premenopausal women. A binary logistic regression analysis showed that menopause was independently associated with MetS (OR = 1.41, 95% CI 1.10-1.82) after adjusting for age, residence area, marital status, family history of cardiovascular disease, education level, and occupation. Conclusions. The present study provides evidence that the MetS is highly prevalent in this group of women. Menopause can be a predictor of MetS independent of age in Tunisian women.

Frequency of Metabolic Syndrome and Study of Anthropometric, Clinical and Biological Characteristics in Peri- and Postmenopausal Women in the City of Ksar El Kebir (Northern Morocco)

“…In our study, according to the NCEP-ATP III definition, the frequency of post-menopausal women with metabolic syndrome (74.18%) was higher than that of peri-menopausal women (50.62%). This result is consistent with other results reported in studies from Thailand [37], Tunisia [38], and Brazil [39]. The study of Ebrahimpour et al [40] revealed that the frequency of metabolic syndrome in women differs according to their menopausal status; it is significantly higher in post-menopausal women [40], which is also consistent with our results.…”

Testosterone a key factor in gender related metabolic syndrome

“…Notably, alterations in gonadal hormones levels represent important risk factors, highly correlated with MetS . Men with low plasma testosterone level have a consistent increase in the CVD risk and women, the incidence of MetS increases after the onset of menopause , because of the decline of plasma oestrogen levels and a relative increase in sex hormone binding globulin (SHBG) and testosterone levels. However, testosterone deficiency can be considered an important marker for CVD and mortality in men, but not in women.…”

Αξιολόγηση Θρέψης Σε Υγιείς Μετεμμηνοπαυσιακές Ελληνίδες

“…Πράγματι, οι εμμηνοπαυσιακές γυναίκες φυσιολογικού σωματικού βάρους, που συμμετείχαν στη μελέτη, και είχαν υψηλό λόγο περιφέρειας μέσης προς περιφέρεια ισχίων, χαρακτηρίζονταν από υψηλότερο πάχος έσω χιτώνα καρωτίδων, κατά 10,5%, σε σύγκριση με τις νορμοβαρείς εμμηνοπαυσιακές γυναίκες φυσιολογικού λόγου μέσης/ισχίων. Η πλειονότητα των υπάρχουσων μελετών(Ben Ali et al 2014, Jouyandeh et al 2013, Pu et al 2017) αναφέρουν αύξηση του κινδύνου εμφάνισης μεταβολικού συνδρόμου κατά την εμμηνόπαυση, γεγονός που ενισχύει την αθηροσκληρυντική διαδικασία.…”