Meniskusveränderungen bei der C57B1 Maus und ihre Bedeutung für die Pathogenese der spontanen Gonarthrose

Pataki, A.; Wilhelmi, G

doi:10.1007/978-3-642-85356-2_17

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…When individual joints were assessed independently in the statistical analysis, two thirds of the instances of relatively slight osteo-arthritis (score 2) could be detected, if questionable, probable and definite radiographic meniscus changes were grouped together. The high diagnostic value of radiographic meniscus changes is not surprising in view of the finding that histological abnormalities of the menisci were already demonstrable in the early stages of osteo-arthritis and paralleled the severity of the disease in both their occurrence and intensity [9]. When both knee joints of each animal are assessed simultaneously and the findings classified without further differentiation as normal, unilateral or bilateral disease, the radiographic identification rate is less good and, at present, not reliable enough to establish a positive diagnosis.…”

Section: Discussionmentioning

confidence: 93%

Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse

et al. 1987

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Experiments were performed to assess the diagnostic value of radiography in osteo-arthritis (OA) of the knee joint in C57Bl mice. Comparative histological and radiographic examination of knee joints from 96 animals showed that if the classical diagnostic criteria (narrowing of the joint space, sclerosis of the subchondral bone, deformation of the joint epiphyses) are applied, OA is not readily detectable by radiography. If these criteria are extended to include radiographic changes in the menisci (enlargement, deformation, increased and/or heterogeneous density), the frequency of detection is much improved. However, except in the severest forms of OA, radiography does not afford a satisfactory means of distinguishing between various degrees of severity. The qualitatively evaluated data nevertheless do suggest that quantitative radiographic diagnosis of OA of the murine knee joint may be useful, both for improving the detection rate and for discriminating various degrees of OA.

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Section: Discussionmentioning

confidence: 93%

Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse

et al. 1987

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“…Since enlargement of the menisci in the mouse is a sensitive indicator of osteo-arthritis of the kneejoint [8,9], and the meniscus size is positively correlated with the histopathology score [4], it may be concluded that in placebo-treated animals the enlargement of the menisci is essentially a manifestation of spontaneous osteo-arthritis of the kneejoint. This conclusion is supported by the concomitant narrowing of the joint space, which is an important diagnostic feature in human osteoarthritis.…”

Section: Discussionmentioning

confidence: 98%

Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone

1990

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“…In later stages of osteo-arthritis, part of these changes can be interpreted as the result of secondary, compensatory processes. The nature of the meniscus changes and their significance in the pathogenesis of degenerative disease of the kneejoint are discussed in full elsewhere [11]. In this context, it need only be emphasized that in the mouse they are above all important as a radiodiagnostic criterion of osteo-arthritis of the knee-joint.…”

Section: Discussionmentioning

confidence: 99%

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

et al. 1990

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Comparative histopathological and radiographic investigations in the C57BL mouse model of spontaneous osteo-arthritis of the knee-joint indicate that there is a relation between quantitative radiographic diagnosis and semiquantitative histopathological diagnosis. Statistical analysis based on a set of quantitative radiographic parameters of the mouse knee-joint shows that the greater part of the radiographic information reflecting the histopathological degree of the osteo-arthritis is contained in the projection areas of the lateral and medial meniscus: progression of the osteo-arthritic process is accompanied with enlargement of the menisci. On the basis of these observations, a radiography score for the osteo-arthritis has been constructed, which consists of a weighted sum of the - suitably transformed - projection areas of the lateral and medial meniscus. In addition to the size of the menisci, the width of the joint space is also a useful quantitative parameter of osteo-arthritis of the mouse knee-joint.

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Meniskusveränderungen bei der C57B1 Maus und ihre Bedeutung für die Pathogenese der spontanen Gonarthrose

Cited by 3 publications

References 11 publications

Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse

Qualitative radiographic diagnosis of osteo-arthritis of the knee joint in the C57BL mouse

Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

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