Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone

Pataki, A.; Graf, Hans Peter; Witzemann, Edgar J.

doi:10.1007/bf01966449

Cited by 10 publications

(3 citation statements)

References 8 publications

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“…Other investigators have previously used image analysis of radiographs to measure the severity of experimental osteoarthritis (27)(28)(29). In these studies, changes in the joint space width, the area and density of the menisci, and the area and density of the femoral and tibia1 epiphyses were measured by image analysis as an index of the severity of spontaneously occurring disease in mice.…”

Section: Discussionmentioning

confidence: 99%

Measurement of radiographic changes in adjuvant-induced arthritis in rats by quantitative image analysis

Esser¹,

Hildebrand²,

Angelo³

et al. 1995

Arthritis & Rheumatism

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Objective. To apply quantitative analytical methods to the evaluation of radiographic images in experimental arthritis.Methods. Adjuvant was used to induce arthritis in rats. Arthritis progression was followed by conventional methods. In addition, digitized images of radiographs of the calcaneus were examined for changes in the mean and in the distribution pattern of gray values. Periosteal new bone formation was measured as an increase in image area of the calcaneus.Results. Significant changes in the gray value profile and increases in periosteal bone formation occurred in arthritic rats. More extensive changes occurred in Lewis rats than in Sprague-Dawley rats. Analysis of serial radiographs revealed an initial decrease in the density of juxtaarticular bone, followed by progressive increases in gray value variation due to concurrent bone loss and bone formation. Eventually, bone formation in arthritic rats resulted in increased gray values above those in nonarthritic rats.Conclusion. Image analysis represents a sensitive, quantitative method for detecting radiographic changes in experimental arthritis.The adjuvant-and collagen-induced models of chronic arthritis are widely used for studies of the underlying pathophysiology of joint disease and for the evaluation of potential new therapeutic agents. In both models, grossly apparent joint inflammation rapidly

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Section: Discussionmentioning

confidence: 99%

Measurement of radiographic changes in adjuvant-induced arthritis in rats by quantitative image analysis

Esser¹,

Hildebrand²,

Angelo³

et al. 1995

Arthritis & Rheumatism

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show abstract

“…It must also be noted that histopathological diagnosis is concerned with only one parameter and radiographic diagnosis with two that are independent of each other, but both change in the course of the disease. Thus, as was to be expected, in a consecutive study quantitative radiographic diagnosis demonstrated the occurrence of meniscus enlargement and narrowing of the joint space as manifestations of the spontaneous progression of the disease [12]. The advantages of quantitative radiographic diagnosis over histopathological diagnosis are also that it is non-invasive and takes much less time.…”

Section: Discussionmentioning

confidence: 92%

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

et al. 1990

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Comparative histopathological and radiographic investigations in the C57BL mouse model of spontaneous osteo-arthritis of the knee-joint indicate that there is a relation between quantitative radiographic diagnosis and semiquantitative histopathological diagnosis. Statistical analysis based on a set of quantitative radiographic parameters of the mouse knee-joint shows that the greater part of the radiographic information reflecting the histopathological degree of the osteo-arthritis is contained in the projection areas of the lateral and medial meniscus: progression of the osteo-arthritic process is accompanied with enlargement of the menisci. On the basis of these observations, a radiography score for the osteo-arthritis has been constructed, which consists of a weighted sum of the - suitably transformed - projection areas of the lateral and medial meniscus. In addition to the size of the menisci, the width of the joint space is also a useful quantitative parameter of osteo-arthritis of the mouse knee-joint.

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“…Spontaneous degenerative knee joint disease has been observed in the C57BL/6 strain. Thus, with age (after 15.5 months) enlargement of menisci as well as narrowing of the joint space has been observed 26,27 . Histological evidence of cartilage destruction as early as 6e8 months of age has been reported, albeit with slow progression, whereby 80% of mice examined showed signs at 16e18 months, and almost all mice showed signs at 2 years 28 .…”

Section: Discussionmentioning

confidence: 95%

Degenerative knee joint disease in mice lacking 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis

Ford-Hutchinson

Ali

Seerattan

et al. 2005

Osteoarthritis and Cartilage

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Spontaneous osteo-arthritis of the knee-joint in C57BL mice receiving chronic oral treatment with NSAID's or prednisone

Cited by 10 publications

References 8 publications

Measurement of radiographic changes in adjuvant-induced arthritis in rats by quantitative image analysis

Measurement of radiographic changes in adjuvant-induced arthritis in rats by quantitative image analysis

Quantitative radiographic diagnosis of osteo-arthritis of the knee-joint in the C57BL mouse

Degenerative knee joint disease in mice lacking 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis

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