Meniscal Replacement Using a Cryopreserved Allograft

Arnoczky, Steven P.; Warren, Russell F.; McDevitt, Cahir A.

doi:10.1097/00003086-199003000-00017

Cited by 133 publications

(68 citation statements)

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“…A central vessel-free zone did not develop in our models; this phenomenon occurs in hyalinised menisci in contrast to frozen or cryopreserved meniscal grafts [4,35].…”

Section: Discussioncontrasting

confidence: 56%

Medial meniscus replacement by a fat pad autograft

Kohn

Rudert

Wirth

et al. 1997

International Orthopaedics

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“…A central vessel-free zone did not develop in our models; this phenomenon occurs in hyalinised menisci in contrast to frozen or cryopreserved meniscal grafts [4,35].…”

Section: Discussioncontrasting

confidence: 56%

Medial meniscus replacement by a fat pad autograft

Kohn

Rudert

Wirth

et al. 1997

International Orthopaedics

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“…In due course, the metabolism returned to normal. This could indicate a â€˜repair phase', a phenomenon also observed by Arnoczky et at (1990). The underlying mechanism, however, is still unknown.…”

Section: Discussionmentioning

confidence: 74%

“…Jackson et al (1992) reported only 30% viability of cryo preserved mernscal chondrocytes immediately after thaw ing from 30 days of storage at â€"156Â°C. Arnoczky et al (1990) found that in dogs, although cryopreservation and short-term storage apparently had no influence on the mor photogical appearance or biomechanical character of the meniscus, only 10% of the meniscal cells were viable, and even these were hypermetabolic. In time this increased metabolic activity returned to normal.…”

Section: Discussionmentioning

confidence: 96%

Human meniscal transplantation. Preliminary results at 2 to 5-year follow-up

Arkel

Boer²

1995

The Journal of Bone and Joint Surgery. British volume

207

136

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“…Several studies reported that immunological rejection was not observed after fresh allogeneic meniscus transplantation 38 or cryopreserved meniscus transplantation that contained up to 10% of the original viable fibrochondrocytes. 39 Freed and collaborators used allogeneic articular chondrocytes seeded on PGA scaffolds for transplantation into the articular cartilage defects in rabbits. The implants were associated with a moderate number of lymphocytes localized in the bone marrow spaces underlying the defects at 1 month.…”

Section: Discussionmentioning

confidence: 99%

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

Kang

Son

Lee

et al. 2006

J Biomedical Materials Res

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Abstract:The current treatments of meniscal lesion in knee joint are not perfect to prevent adverse effects of meniscus injury. Tissue engineering of meniscus using meniscal cells and polymer scaffolds could be an alternative option to treat meniscus injury. This study reports on the regeneration of whole medial meniscus in a rabbit total meniscectomy model using the tissue engineering technique. Biodegradable scaffolds in a meniscal shape were fabricated from polyglycolic acid (PGA) fiber meshes that were mechanically reinforced by bonding PGA fibers at cross points with 75:25 poly(lactic-co-glycolic acid). The compressive modulus of the bonded PGA scaffold was 28-fold higher than that of nonbonded scaffold. Allogeneic meniscal cells were isolated from rabbit meniscus biopsy and cultured in vitro. The expanded meniscal cells were seeded onto the polymer scaffolds, cultured in vitro for 1 week, and transplanted to rabbit knee joints from which medial menisci were removed. Ten or 36 weeks after transplantation, the implants formed neomenisci with the original scaffold shape maintained approximately. Hematoxylin and eosin staining of the sections of the neomenisci at 6 and 10 weeks revealed the regeneration of fibrocartilage. Safranin-O staining showed that abundant proteoglycan was present in the neomenisci at 10 weeks. Masson's trichrome staining indicated the presence of collagen. Immunohistochemical analysis showed that the presence of type I and II collagen in neomenisci at 10 weeks was similar to that of normal meniscal tissue. Biochemical and biomechanical analyses of the tissue-engineered menisci at 36 weeks were performed to determine the quality of the tissue-engineered menisci. Tissue-engineered meniscus showed differences in collagen content and aggregate modulus in comparison with native meniscus. This study demonstrates, for the first time, the feasibility of regenerating whole meniscal cartilage in a rabbit total meniscectomy model using the tissue engineering method.

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Meniscal Replacement Using a Cryopreserved Allograft

Cited by 133 publications

References 0 publications

Medial meniscus replacement by a fat pad autograft

Medial meniscus replacement by a fat pad autograft

Human meniscal transplantation. Preliminary results at 2 to 5-year follow-up

Regeneration of whole meniscus using meniscal cells and polymer scaffolds in a rabbit total meniscectomy model

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