Meningoencephalitis in an Adult Cow Due to <i>Mortierella Wolfii</i>

Munday, John S.; Laven, Richard; Orbell, Geoff; Pandey, Sushil

doi:10.1177/104063870601800620

Cited by 15 publications

(18 citation statements)

References 18 publications

(42 reference statements)

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“…A meningite é a inflamação das camadas que envolvem o sistema nervoso central (SNC) e pode ser de origem viral, bacteriana (Fecteau & George, 2004;Barros et al, 2006), fúngica (Munday et al, 2006) e protozoária (Pimentel et al, 2012 (Marchen et al, 2005;Barros et al, 2006;Lemos & Brum, 2007;Schumacher et al, 2011).…”

Section: Introductionunclassified

MENINGOENCEFALITE POR Escherichia coli EM CABRITO

Nascimento

Câmara²,

Oliveira³

et al. 2014

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RESUMO -O presente trabalho objetivou relatar os achados epidemiológicos, clínico-patológicos e laboratoriais de um cabrito de dois meses de idade com meningoencefalite por Escherichia coli. Ao exame clínico observou-se decúbito lateral, vocalização, opistótono, rigidez muscular cervical, opacidade bilateral de córnea, febre (41,3ºC), taquicardia, desidratação, urina avermelhada e movimentos de pedalagem. A hematologia mostrou discreta leucocitose com monocitose absoluta. A bioquímica sérica apresentou-se dentro dos padrões fisiológicos para a espécie. A análise do líquido cefalorraquiano (LCR) revelou aspecto turvo, coloração amarelo claro, pleocitose (598 leucócitos/µL) neutrofílica e presença de bactérias. O animal veio a óbito aproximadamente duas horas após o exame clínico. A necropsia revelou hiperemia, opacidade e presença de exsudato fibrinopurulento nas meninges, sulcos do córtex cerebral e tronco encefálico; e os rins com severa congestão. Microscopicamente, observou-se infiltrado inflamatório misto envolvendo as meninges das regiões do córtex parietal, temporal e tronco encefálico associado a colônias bacterianas. Edema e degeneração neuronal também foram evidentes. A cultura microbiológica de alíquota do LCR permitiu o isolamento de E. coli. Palavras-Chave: doenças bacterianas; Escherichia coli; meningoencefalite; neuropatologia; sistema nervoso central.ABSTRACT -This study aimed to report the epidemiological, clinical-pathological and laboratory findings in a 2-month-old kid with meningoencephalitis by Escherichia coli. Clinical examination revealed lateral recumbency, vocalization, opisthotonos, neck stiffness, bilateral corneal opacity, fever (41.3°C), tachycardia, dehydration, reddish urine and paddling. Hematology revealed light leukocytosis with absolute monocitosis. Serum biochemistry was within physiological standards for the specie. Cerebrospinal fluid (CSF) analysis showed turbid aspect, light yellow coloration, neutrophilic pleocytosis (598 leukocytes/µL) and bacteria. The animal died about two hours after the clinical exam. Necropsy findings consisted of hyperemia, opacity and presence of fibrinopurulent exudate in the meninges, cerebral cortex sulci and brain stem; while the kidneys showed severe congestion. Microscopically, there was a mixed inflammatory infiltrate involving the meninges of the regions of the parietal, temporal cortex and brainstem associated to bacterial colonies. Edema and neuronal degeneration was also noted. Microbiological culture of a CSF aliquot allowed the isolation of E. coli.

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Section: Introductionunclassified

MENINGOENCEFALITE POR Escherichia coli EM CABRITO

Nascimento

Câmara²,

Oliveira³

et al. 2014

AVB

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“…21 Additionally, as in our case, molecular techniques can aid in etiologic diagnosis. 16 Bovine mycotic abortions occur worldwide and are generally sporadic with a propensity for the third trimester. 1,11,25 Aspergillus spp.…”

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Embolic mycotic encephalitis in a cow following Mortierella wolfii infection of a surgery site

et al. 2017

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A 5-y-old Holstein dairy cow had surgery for a suspected displaced abomasum 10 d postpartum, developed acute neurologic signs at day 19, and was found dead 21 d postpartum. At autopsy, there was a peri-incisional intramuscular abscess that communicated with the peritoneal cavity, as well as hemorrhage and malacia involving the brain, and multiple nodules in the liver, kidneys, and lungs. Fungal hyphae were seen histologically at the surgery site, on the surface of the liver, and in lesions of severe necrotizing vasculitis in the lungs, kidneys, brain, and liver. The uterus was free of fungal organisms. Pan-fungal PCR and DNA sequencing identified the fungus as Mortierella wolfii. Previously reported deaths from M. wolfii have been related to abortion, but in this case, there was no histologic evidence of fungal organisms in the uterus, calving was routine, and there was a several week delay between calving and development of neurologic signs. The findings suggested a unique case of surgical site infection with subsequent embolic mycosis.

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“…Hyphae have the ability to invade endothelial cells, gain access to the circulatory system, and spread to other parts of the body. The presence of infarcts, necrosis, and vasculitis are considered characteristic lesions that occur secondary to the fungal invasion of the blood vessels (MUNDAY et al, 2006;ZACHARY, 2017), as observed in this case.…”

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Fatal systemic Mortierella wolfii infection in a neonatal calf in southern Brazil

et al. 2020

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This study described the pathological and microbiological aspects of a fatal systemic Mortierella wolfii infection in a neonatal calf in southern Brazil. The calf was born clinically normal, but on the third day of life it presented apathy, unilateral hypopyon, and neurological signs, and in the next day it was euthanized. At necropsy, multiple soft, and white-yellow nodules were observed in the liver, spleen, kidneys, mesenteric lymph nodes, heart, and lungs. In the brain, reddish, and friable areas were found. In the eye, there were anterior and posterior synechiae, diffuse thickening of choroid, and anterior chamber filled by whitish and friable material. Microscopically, areas of necrosis, pyogranulomatous inflammation, vasculitis, thrombosis, and intralesional fungal hyphae were observed, and the latter were better evidenced through Grocott Methenamine Silver technique. The fungus was identified as M. wolfii through mycological culture and molecular methods. To our knowledge, this is the first description of systemic disease caused by M. wolfii in a neonatal calf outside of Oceania.

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Meningoencephalitis in an Adult Cow Due to Mortierella Wolfii

Cited by 15 publications

References 18 publications

MENINGOENCEFALITE POR Escherichia coli EM CABRITO

MENINGOENCEFALITE POR Escherichia coli EM CABRITO

Embolic mycotic encephalitis in a cow following Mortierella wolfii infection of a surgery site

Fatal systemic Mortierella wolfii infection in a neonatal calf in southern Brazil

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