Meningoencephalitis from<i>Borrelia miyamotoi</i>in an Immunocompromised Patient

Gugliotta, Joseph L.; Goethert, Heidi K.; Berardi, Victor P.; Telford, Sam R.

doi:10.1056/nejmoa1209039

Cited by 239 publications

(221 citation statements)

References 27 publications

(25 reference statements)

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“…23,45,46 Recent work has also implicated it as a potential cause of meningoencephalitis. 47,48 The prevalence of Anaplasma spp. infection in our study was 1.7%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Croatia is a focus for many rodent-borne zoonosis. Here, we report a survey of 242 rodents and small mammals, including 43 Myodes glareolus, 131 Apodemus flavicollis, 53 Apodemus agrarius, three Apodemus sylvaticus, six Sorex araneus, four Microtus arvalis, one Microtus agrestis, and one Muscardinus avellanarius, collected at eight sites in Croatia over an 8-year period. Multiplex MassTag polymerase chain reaction (PCR) was used for detection of Borrelia, Rickettsia, Bartonella, Babesia, Ehrlichia, Anaplasma, Francisella tularensis, and Coxiella burnetii. Individual PCR assays were used for detection of Leptospira, lymphocytic choriomeningitis virus, orthopoxviruses, flaviviruses, hantaviruses, and Toxoplasma gondii. Of the rodents, 52 (21.5%) were infected with Leptospira, 9 (3.7%) with Borrelia miyamotoi, 5 (2%) with Borrelia afzelii, 29 (12.0%) with Bartonella, 8 (3.3%) with Babesia microti, 2 (0.8%) with Ehrlichia, 4 (1.7%) with Anaplasma, 2 (0.8%) with F. tularensis, 43 (17.8%) with hantaviruses, and 1 (0.4%) with an orthopoxvirus. Other agents were not detected. Multiple infections were found in 32 rodents (13.2%): dual infections in 26 rodents (10.7%), triple infections in four rodents (2.9%), and quadruple infections in two rodents (0.8%). Our findings indicate that rodents in Croatia harbor a wide range of bacteria and viruses that are pathogenic to humans.

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“…23,45,46 Recent work has also implicated it as a potential cause of meningoencephalitis. 47,48 The prevalence of Anaplasma spp. infection in our study was 1.7%.…”

Section: Discussionmentioning

confidence: 99%

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Tadin¹,

Tokarz²,

Markotić³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Borrelia miyamotoi Fukunaga was isolated from field mice and I. persulcatus in Japan in 1994 [64] and subsequently reported in a US human in 2013 [65]. This pathogen is closely related to relapsing fever spirochetes and this may impact transmission.…”

Section: Borrelia Miyamotoi (Borrelia Myamotoi Disease Borreliosis)mentioning

confidence: 99%

Do Tick Attachment Times Vary between Different Tick-Pathogen Systems?

et al. 2017

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Improvements to risk assessments are needed to enhance our understanding of tick-borne disease epidemiology. We review tick vectors and duration of tick attachment required for pathogen transmission for the following pathogens/toxins and diseases: (1) Anaplasma phagocytophilum (anaplasmosis); (2) Babesia microti (babesiosis); (3) Borrelia burgdorferi (Lyme disease); (4) Southern tick-associated rash illness; (5) Borrelia hermsii (tick-borne relapsing fever); (6) Borrelia parkeri (tick-borne relapsing fever); (7) Borrelia turicatae (tick-borne relapsing fever); (8) Borrelia mayonii; Reported tick attachment times varied (<1 h to seven days) between pathogen/toxin type and tick vector. Not all studies were designed to detect the duration of attachment required for transmission. Knowledge of this important aspect of vector competence is lacking and impairs risk assessment for some tick-borne pathogens.

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“…Ezért magyarországi előfordulásával is számolni kell. Egyelőre sokkal több országban találtak a kullancsokban B. miyamotoi-t, mint amennyiben humán megbetegedést észleltek (1. és 3. táblázat [34][35][36][37][38][39][40]). Ez érthető, hiszen mind a klinikai, mind a laboratóriumi diagnózis nehézkes.…”

Section: Klinikum éS Epidemiológiaunclassified

“…Bm = Borrelia miyamotoi; Rf = visszatérő lázat okozó baktérium (Relapsing fever) ÖSSZEFOGLALÓ KÖZLEMÉNY szenvedő, immunszupprimált emberben alakult ki meggyőzően alátámasztott, B. miyamotoi által okozott meningoencephalitis [34,35]. Mindegyik esetben lymphocytás pleocytosis és magas fehérjeszint volt a likvorban, ugyanúgy, mint a Lyme-betegségben.…”

Section: Klinikum éS Epidemiológiaunclassified

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

Szekeres

Lakos²,

Földvári

2017

Orvosi Hetilap

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A Borrelia miyamotoi-t 1995-ben fedezték fel. Ez egy, emberben visszatérő lázat (relapsing fever, febris recurrens) okozó baktérium, amelyet az Ixodes ricinus fajcsoportba tartozó kullancsok terjesztenek. Ez a kórokozó genetikailag, járványtanilag és az általa okozott kórkép tekintetében is különbözik a szintén kullancsok által terjesztett Borrelia burgdorferi sensu lato (Lyme spirochaeta) baktériumoktól. Eddig világszerte több mint 50 heveny lázas megbetegedésben szenvedő páciensből mutatták már ki, ezenfelül három tumoros betegben meningoencephalitist okozott ez a kórokozó. A különböző élőhelyeken található kullancsok és gazdáik fertőzöttségének mértéke, eloszlása és a fertőzés mechanizmusa nem tisztázott még. A B. miyamotoi elsősorban lázat okoz, ami miatt más, kullancsok által terjesztett fertőzésekkel is összetéveszthető. Az utóbbi évek intenzív vizsgálatai alapján nemcsak egyre több földrajzi régióból mutatják ki ezt a baktériumot kullancsokból, de folyamatosan növekszik a publikált humán esetszám is, ezért növek-vő jelentőségű (emerging) kórokozóként tartják számon. Irodalmi áttekintésünkben összegezzük az eddigi ismereteinket a Borrelia miyamotoi-val kapcsolatban. Orv Hetil. 2017; 158(29): 1124-1130. Kulcsszavak: Borrelia miyamotoi, kullancs, visszatérő láz, kullancs által terjesztett fertőzések Borrelia miyamotoi: a recently identified human pathogenic tick-borne relapsing fever spirocheteBorrelia miyamotoi is a recently described relapsing fever spirochete transmitted by ticks of the Ixodes ricinus complex. This pathogen is different from Borrelia burgdorferi sensu lato (the Lyme borreliosis spirochetes) in its epidemiology, ecology and also genetics. Over 50 patients have been described worldwide with Borrelia miyamotoi disease, and three immunocompromised patients were reported with neurological symptoms. Our knowledge about Borrelia miyamotoi infection in ticks and its distribution in different habitats and also the mechanism of the infection is limited. The most common symptom is fever; thus it can be easily confused with other tick-borne diseases. Due to the intensive research in recent years, Borrelia miyamotoi infection in ticks and hosts has been reported from different regions and also the number of patients is increasing, thus this bacterium is considered as an emerging pathogen. In this literature review we would like to summarize the available knowledge about this spirochete.

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Meningoencephalitis fromBorrelia miyamotoiin an Immunocompromised Patient

Cited by 239 publications

References 27 publications

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Molecular Survey of Zoonotic Agents in Rodents and Other Small Mammals in Croatia

Do Tick Attachment Times Vary between Different Tick-Pathogen Systems?

Borrelia miyamotoi: egy újabb, humán patogén, kullancs által terjesztett, visszatérő lázat okozó baktérium

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