Meningococcal carriage: Prevalence and sex-related risk factors

Tayal, S C; Rashid, Sakina Mehboob; Muttu, K.M.S.; Hildreth, Anthony

doi:10.1016/s0163-4453(97)92357-4

Cited by 7 publications

(3 citation statements)

References 17 publications

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“…gonorrhoeae coming together despite their different habitats. A previous study conducted by Tayal SC, et al, found no relationship of meningococcal carriage with sexual orientation and orogenitaI sex [ 25 ]. However, cases of genital tract infections or colonization due to N .…”

Section: Discussionmentioning

confidence: 99%

Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

et al. 2015

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BackgroundMeningococcal carriage studies are important to improve our understanding of the epidemiology of meningococcal disease. The aim of this study was to determine the prevalence of meningococcal carriage and the phenotypic and genotypic characteristics of isolates collected from a sample of students in the city of Bogotá, Colombia.Materials and MethodsA total of 1459 oropharyngeal samples were collected from students aged 15–21 years attending secondary schools and universities. Swabs were plated on a Thayer Martin agar and N. meningitidis was identified by standard microbiology methods and PCR.ResultsThe overall carriage prevalence was 6.85%. Carriage was associated with cohabitation with smokers, and oral sex practices. Non-groupable and serogroup Y isolates were the most common capsule types found. Isolates presented a high genetic diversity, and circulation of the hypervirulent clonal complexes ST-23, ST-32 and ST-41/44 were detected.ConclusionThe meningococcal carriage rate was lower than those reported in Europe and Africa, but higher than in other Latin American countries. Our data also revealed antigenic and genetic diversity of the isolates and the circulation of strains belonging to clonal complexes commonly associated with meningococcal disease.

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Section: Discussionmentioning

confidence: 99%

Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

et al. 2015

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“…Higher meningococcal carriage prevalence among MSM is reported in the literature [39–41], and recently, several MenC-outbreaks involved gay, bisexual and other MSM in Europe and US [16, 42]. What promote the spread of meningococci among this population-group is partially explained by the high prevalence of risk behaviours reported in the literature among MSM that facilities frequent close-contacts, but also to an unique mechanism of sexual-transmission or a specific-susceptibility [16, 42].…”

Section: Discussionmentioning

confidence: 99%

Carriage rates and risk factors during an outbreak of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11) in Tuscany, Italy: a cross-sectional study

Miglietta

Innocenti²,

Pezzotti

et al. 2019

BMC Infect Dis

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BackgroundDuring 2015–2016 an outbreak of invasive meningococcal disease due to N. meningitidis serogroup C ST-11 (cc11) occurred in Tuscany, Italy. The outbreak affected mainly the age group 20–30 years, men who have sex with men, and the area located between the cities of Firenze, Prato and Empoli, with discos and gay-venues associated-clusters. A cross-sectional-survey was conducted to assess the prevalence and risk factors for meningococcal-carriage, in order to address public health interventions.MethodsA convenience sample of people aged 11–45 years provided oropharyngeal swab specimens and completed questionnaires on risk factors for meningococcal carriage during a 3 months study-period, conducted either in the outbreak-area and in a control-area not affected by the outbreak (cities of Grosseto and Siena). Isolates were tested by culture plus polymerase chain reaction. Serogroup C meningococcal isolates were further characterized using multilocus sequence typing. Univariate and multivariate analyses were performed to estimate adjusted odds ratios (AORs) for meningococcal carriage.ResultsA total of 2285 oropharyngeal samples were collected. Overall, meningococcal carriage prevalence was 4.8% (n = 110), with nonencapsulated meningococci most prevalent (2.3%; n = 52). Among encapsulated meningococci, serogroup B was the most prevalent (1.8%; n = 41), followed by serogroup Y (0.5%; n = 11) and serogroup C (0.2%; n = 4); one carrier of serogroup E and one of serogroup Z, were also found (0.04%). Three individuals from the city of Empoli were found to carry the outbreak strain, C:ST-11 (cc11); this city also had the highest serogroup C carriage prevalence (0.5%). At the multivariate analyses, risk factors for meningococcal carriage were: illicit-drugs consumption (AOR 6.30; p < 0.01), active smoking (AOR 2.78; p = 0.01), disco/clubs/parties attendance (AOR 2.06; p = 0.04), being aged 20–30 years (AOR 3.08; p < 0.01), and have had same-sex intercourses (AOR 6.69; p < 0.01).ConclusionsA low prevalence of meningococcal serogroup C carriage in an area affected by an outbreak due to the hypervirulent N. meningitidis serogroup C ST-11 (cc11) strain was found. The city of Empoli had the highest attack-rate during the outbreak and also the highest meningococcal serogroup C carriage-prevalence due to the outbreak-strain. Multivariate analyses underlined a convergence of risk factors, which partially confirmed those observed among meningococcal outbreak-cases, and that should be considered in targeted immunization campaigns.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3598-3) contains supplementary material, which is available to authorized users.

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“…In our study, we found that both male sex and home type (i.e., mobile home or apartment vs. a single-family home) were associated with meningococcal carriage. Higher carriage and disease rates have been reported among males elsewhere [23,45]. The increase in carriage among mobile home or apartment residents is likely a proxy for density and close contact within the home, which is known to be a major risk factor for meningococcal disease [49][50][51], and was different between the 2 counties.…”

Section: Discussionmentioning

confidence: 99%

Genotype‐Specific Carriage ofNeisseria meningitidisin Georgia Counties with Hyper‐ and Hyposporadic Rates of Meningococcal Disease

et al. 2002

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Carriage of Neisseria meningitidis in a Georgia county with hypersporadic incidence of meningococcal disease ("hypersporadic county") and in a county with no cases of meningococcal disease was determined by a cross-sectional pharyngeal culture study of high school students. Among 2730 students from whom culture samples were obtained, meningococcal carriage was 7.7% (140/1818) in the hypersporadic county and 6.1% (56/912) in the comparison county. Carriage rates by serogroup and genetic type (i.e., electrophoretic type [ET]) did not differ significantly between counties, but apartment or mobile home residency was a risk factor for carriage in the hypersporadic county. Although most cases of meningococcal disease in the hypersporadic county were caused by members of the serogroup C ET-37 clonal group, no ET-37 meningococcal isolates were recovered from carriers in this county. However, 38% of all meningococcal isolates recovered from carriers in both counties were members of the serogroup Y ET-508 clonal group, an emerging cause of meningococcal disease in Georgia and throughout the United States during 1996-2001. Shifts in carriage and transmission of meningococcal strains with different pathogenic potential are important determinants of meningococcal disease incidence.

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Meningococcal carriage: Prevalence and sex-related risk factors

Cited by 7 publications

References 17 publications

Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

Carriage rates and risk factors during an outbreak of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11) in Tuscany, Italy: a cross-sectional study

Genotype‐Specific Carriage ofNeisseria meningitidisin Georgia Counties with Hyper‐ and Hyposporadic Rates of Meningococcal Disease

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