Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

Moreno, Jaime; Hidalgo, Manuel; Duarte, Carolina; Sanabria, Olga; Gabastou, Jean Marc; Ibarz-Pavón, Ana Belén

doi:10.1371/journal.pone.0135497

Cited by 27 publications

(46 citation statements)

References 39 publications

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“…This comes in agreement with previous studies at a European level as well as studies in Latin America in which this diversity seem to be a stable feature [30, 32]. …”

Section: Discussionsupporting

confidence: 93%

“…The application of the MLST technique showed that the major types (sequence types, ST) prevailing in our country during the period 2004–2014 among the MenB IMD cases were the ST-269 (14,7%), ST-32 (10,5%), ST- 162 (5,7%) and to lesser extent 41/44cc (5.6%) [29]. The latter clonal complex, one of the most prevalent hyperinvasive lineage being associated mainly with the MenB IMD in Europe and elsewhere [30] was the most prevalent (30%) among the MenB asymptomatic carriers. This observation is of a great concern and must be under close surveillance since this particular lineage can potentially cause epidemic waves such as the New Zealand epidemic [31].…”

Section: Discussionmentioning

confidence: 99%

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Meningococcal Carriage in Military Recruits and University Students during the Pre MenB Vaccination Era in Greece (2014-2015)

et al. 2016

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PurposeThe aim of the study was to estimate the meningococcal carriage rate and to identify the genotypic characteristics of the strains isolated from healthy military recruits and university students in order to provide data that might increase our understanding on the epidemiology of meningococcus and obtain information which helps to evaluate the potential effects on control programs such as vaccination.,MethodsA total of 1420 oropharyngeal single swab samples were collected from military recruits and university students on voluntary basis, aged 18–26 years. New York City Medium was used for culture and the suspected N. meningitidis colonies were identified by Gram stain, oxidase and rapid carbohydrate utilization tests. Further characterisation was carried out by molecular methods (multiplex PCR, MLST, WGS).ResultsThe overall carriage rate was of 12.7%; 15% and 10.4% for recruits and university students respectively. MenB (39.4%) was the most prevalent followed by MenY (12.8%) and MenW (4.4%). Among the initial 76 Non Groupable (NG) isolates, Whole Genome Sequence Analysis (WGS) revealed that 8.3% belonged to MenE, 3.3% to MenX and 1.1% to MenZ, while, 53 strains (29.4%) were finally identified as capsule null. Genetic diversity was found among the MenB isolates, with 41/44 cc and 35 cc predominating.ConclusionMeningococcal carriage rate in both groups was lower compared to our previous studies (25% and 18% respectively) with predominance of MenB isolates. These findings, help to further our understanding on the epidemiology of meningococcal disease in Greece. Although the prevalence of carriage seems to have declined compared to our earlier studies, the predominant MenB clonal complexes (including 41/44cc and 35cc) are associated with invasive meningococcal disease.

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“…This comes in agreement with previous studies at a European level as well as studies in Latin America in which this diversity seem to be a stable feature [30, 32]. …”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Meningococcal Carriage in Military Recruits and University Students during the Pre MenB Vaccination Era in Greece (2014-2015)

et al. 2016

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“…The overall prevalence for adolescents in Salvador was lower than the prevalence (9.9%) observed in a similar study performed in Campinas, Brazil, after introducing the MCC vaccine among children <2 years old [15]. Moreover, our results were similar to those of studies from other Latin American countries, such as Colombia (6.85%) [20] and Chile (6.5%) [21]. …”

Section: Discussionsupporting

confidence: 84%

“…In addition, even though men are the most prevalent meningococcal carriers worldwide [13], sex was not associated with meningococcal carriage in our study [15, 20]. …”

Section: Discussionmentioning

confidence: 64%

Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil

et al. 2016

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Neisseria meningitidis is a commensal bacterium of the human nasopharynx. In rare cases, it penetrates the mucosa, entering the blood stream and causing various forms of disease. Meningococcal conjugate vaccines can prevent invasive disease not only by direct effect in vaccinated individuals but also by herd protection, preventing acquisition of carriage, which interrupts transmission and leads to protection of unvaccinated persons. In 2010 in Salvador, Brazil, an outbreak of group C meningococcal disease led to a mass meningococcal serogroup C conjugate vaccination drive, targeting those <5 and 10–24 years of age. The present study aimed to estimate the prevalence of and identify factors associated with N. meningitidis carriage among adolescents from Salvador, Brazil, in the post-vaccination period. In spring 2014, we performed a cross-sectional study involving 1,200 public school students aged 11–19 years old. Oropharyngeal swabs were collected to identify N. meningitidis. Of the 59 colonized participants, 36 (61.0%) carried non-groupable N. meningitidis, while genogroup B (11.9%), Y (8.5%), E (6.8%), Z (5.1%), C (3.4%), and W (3.4%) were also detected. The overall prevalence of N. meningitidis carriage was 4.9% (95% confidence interval [CI], 3.6–6.1%); the prevalence of N. meningitidis genogroup C was 0.17% (95% CI, 0.0–0.40%). There was no difference by age. Factors associated with carriage were having only one, shared, bedroom in the household (PR, 2.02; 95% CI, 0.99–4.12, p = 0.05); the mother being the only smoker in the home (PR, 2.48; 95% CI, 1.16–5.29; p = 0.01); and going to pubs/parties more than 5 times/month (PR, 2.61; 95% CI, 1.38–4.92; p = 0.02). Our findings show that the N. meningitidis carriage rate in adolescents from Salvador, Bahia, is low and is potentially influenced by the low prevalence of N. meningitidis genogroup C. However, continued surveillance is important to identify changes in the dynamics of N. meningitidis, including the emergence of diseases due to a non-C serogroup.

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“…Smoking is recognized as being a risk factor for meningococcal carriage [6,17]. While this study found no evidence of such an association very few participants were smokers, preventing us from being able to meaningfully investigate this aspect.…”

Section: Discussioncontrasting

confidence: 64%

Meningococcal carriage in children and young adults in the Philippines: a single group, cross-sectional study

2016

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SUMMARYThis cross-sectional prevalence study investigates meningococcal carriage for the first time in a Southeast Asian population. Posterior pharyngeal swabs were collected between August 2013 and March 2014 from 937 healthy Filipinos aged 5-24 years attending school or university in Manila. Of these, 35 were found to be carriers giving an overall carriage prevalence of 3·7% [95% confidence interval (CI) 2·6-5·2]. Carriage was associated with age (P < 0·001) and was highest (9·0%, 95% CI 5·5-13·8) in subjects aged 10-14 years, but was comparatively low (<3%) in all other age groups considered. This suggests that an immunization programme in the Philippines designed to reduce carriage acquisition and induce herd immunity may require a vaccine dose before the age of 10 years. Serogroup B was most commonly carried (65·7%, 95% CI 47·8-80·9), with a small number of carriers for serogroups C, Y and W also present. Two individuals (5·7%, 95% CI 0·7-19·2) who were simultaneously carrying multiple serogroups were identified. This exploratory study provides valuable insight into the asymptomatic carriage of Neisseria meningitidis in a healthy subset of the Filipino population and illustrates the importance of generating local carriage data.

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Characterization of Carriage Isolates of Neisseria meningitidis in the Adolescents and Young Adults Population of Bogota (Colombia)

Cited by 27 publications

References 39 publications

Meningococcal Carriage in Military Recruits and University Students during the Pre MenB Vaccination Era in Greece (2014-2015)

Meningococcal Carriage in Military Recruits and University Students during the Pre MenB Vaccination Era in Greece (2014-2015)

Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil

Meningococcal carriage in children and young adults in the Philippines: a single group, cross-sectional study

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