Meningitis registry of hospitalized cases in children: epidemiological patterns of acute bacterial meningitis throughout a 32-year period

Theodoridou, Maria; Vasilopoulou, Vasiliki; Atsali, Erato E; Pangalis, A.; Mostrou, Glykeria; Syriopoulou, Vassiliki; Hadjichristodoulou, Christos

doi:10.1186/1471-2334-7-101

Cited by 68 publications

(65 citation statements)

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“…As reported in previous studies 2,13,22,35 , males have a higher risk of being infected by bacterial meningitis in Salvador.…”

Section: Conflict Of Interest Referencessupporting

confidence: 65%

“…The occurrence of bacterial meningitis varies greatly between and within regions, countries, states, and municipalities, both in relation to the age groups most affected and to the frequency of the most prevalent etiological agents, principally following the inclusion of conjugate vaccines in the basic immunization schedule for children [2][3][4][5] . It should be emphasized, therefore, that the available scientific literature on the incidence and lethality of these forms of meningitis generally involve different age groups and/or only the main etiological agents or, sometimes, may refer to specific healthcare services, making comparisons difficult.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial meningitis and living conditions

Souza

Costa

Paim

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: Bacterial meningitis has great social relevance due to its ability to produce sequelae and cause death. It is most frequently found in developing countries, especially among children. Meningococcal meningitis occurs at a high frequency in populations with poor living conditions. This study describes the temporal evolution of bacterial meningitis in Salvador, Brazil, 1995, and verifies the association between its spatial variation and the living conditions of the population. Methods: This was an ecological study in which the areas of information were classified by an index of living conditions. It examined fluctuations using a trend curve, and the relationship between this index and the spatial distribution of meningitis was verified using simple linear regression. Results: From 1995-2009, there were 3,456 confirmed cases of bacterial meningitis in Salvador. We observed a downward trend during this period, with a yearly incidence of 9.1 cases/100,000 population and fatality of 16.7%. Children aged <5 years old and male were more affected. There was no significant spatial autocorrelation or pattern in the spatial distribution of the disease. The areas with the worst living conditions had higher fatality from meningococcal disease (β = 0.0078117, p < 0.005). Conclusions: Bacterial meningitis reaches all social strata; however, areas with poor living conditions have a greater proportion of cases that progress to death. This finding reflects the difficulties for ready access and poor quality of medical care faced by these populations.

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“…As reported in previous studies 2,13,22,35 , males have a higher risk of being infected by bacterial meningitis in Salvador.…”

Section: Conflict Of Interest Referencessupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Bacterial meningitis and living conditions

Souza

Costa

Paim

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

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“…Although vaccination strategies, antibiotic treatment and adequate hospital care can strongly reduce its negative consequences, BM remains the cause of substantial morbidity and mortality both in developing and developed countries (1)(2)(3) .…”

Section: Introductionmentioning

confidence: 99%

“…In Brazil, according to the Disease Reporting System (Sistema de Agravos de Notificação), almost 65,000 children had meningitis from 2007 to 2010, 3,770 of which died, characterizing a 5.8% mortality (4) . Long-term morbidity, especially morbidity related to persistent neurological sequelae, happens in approximately 15% of patients (5) .…”

Section: Introductionmentioning

confidence: 99%

Revisão sistemática do uso da dexametasona como terapia adjuvante na meningite bacteriana em crianças

Prats

Gaspar

Ribeiro

et al. 2012

Rev. paul. pediatr.

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Revisão sistemática do uso da dexametasona como terapia adjuvante na meningite bacteriana em criançasRevisión sistemática del uso de la dexametasona como terapia adyuvante en la meningitis bacteriana en niños João Antonio G. G ABSTRACTObjective: To analyze the best available evidence from the last 15 years on the benefits of adjuvant therapy with dexamethasone for bacterial meningitis in children.Data sources: Randomized controlled trials comparing dexamethasone to placebo and/or other adjuvant therapies in patients with bacterial meningitis diagnosed by biochemical, cytological and/or microbiological data. Studies with patients from 29 days to 18 years of age, from 1996 to 2011, were searched at Medline, Lilacs and SciELO databases. The evaluated outcomes were mortality and development of neurological and/or hearing impairment. Studies related to tuberculous meningitis were excluded.Data synthesis: With the specified criteria, five published studies were identified corresponding to four study protocols. None of the studies showed differences between dexamethasone and placebo for the evaluated outcomes. All analyzed studies had high methodological quality (Jadad et al score=5).Conclusions: Current evidence is insufficient to support routine adjuvant therapy with dexamethasone to reduce mortality, hearing impairment, or neurological sequelae in pediatric patients with non-tuberculous bacterial meningitis.Key-words: meningitis, bacterial; dexamethasone; deafness; mortality. RESUMOObjetivo: Analisar a melhor evidência disponível nos últimos 15 anos com relação aos benefícios da terapia adjuvante com dexametasona na meningite bacteriana em população pediátrica.Fontes de dados: Das bases de dados Medline, Lilacs e SciELO, foram analisados ensaios clínicos randomizados de 1996 a 2011, os quais comparavam a dexametasona ao placebo e/ou a outra terapia adjuvante em pacientes com meningite bacteriana diagnosticada laboratorialmente por critérios quimiocitológicos e/ou bacteriológicos, na faixa etária de 29 dias aos 18 anos. Os desfechos avaliados foram mortalidade e ocorrência de sequelas neurológicas e/ou auditivas. Foram excluídos estudos relacionados à meningite tuberculosa.Síntese dos dados: Com os critérios utilizados, foram identificadas cinco publicações correspondentes a quatro protocolos de estudo. Nenhum dos estudos mostrou diferenças entre a dexametasona e o placebo para os desfechos avaliados. Os estudos analisados tiveram alta qualidade (escore de Jadad et al=5).Conclusões: As evidências encontradas na literatura são insuficientes para indicar de forma rotineira o uso da dexametasona como terapia adjuvante para redução de mortalidade, perda auditiva e sequelas neurológicas em pacientes pediátricos com meningite bacteriana não tuberculosa.Palavras-chave: meningite bacteriana; dexametasona; surdez; mortalidade. João Antonio G. G. Prats et al RESUMEN Objetivo:El presente estudio tiene por objetivo el análisis de la mejor evidencia disponible los últimos 15 años respecto a los beneficios de la terapia adyuvant...

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“…Haemophillus influenza, Streptococcus pneumoniae and Neisseria meningitides are organisms most frequently implicated in causation of bacterial meningitis in the older children while Group B Streptococcus, Gram negative Coliforms Escherichia coli and Listeria monocytogenes are organisms most frequently implicated in neonates [9]. Signs of infections like meningitis are usually nonspecific in the new born hence diagnosis of meningitis must be by lumbar puncture with subsequent analysis of the cerebrospinal fluid [10].…”

Section: Introductionmentioning

confidence: 99%