Meningismus Associated with Malpositioned Intraspinal Catheter for Drug Delivery

Abstract

Meningismus from malpositioned catheters is a rare complication that can mimic meningitis but should be considered in the differential for postimplant headaches. Given the increased use of IDDS, it is important to recognize and evaluate postimplant complication and treat it appropriately. We discuss this case report and appropriate work-up and differential diagnosis for meningismus following implant.

Nanopore Generation in Biodegradable Silk/Magnetic Nanoparticle Membranes by an External Magnetic Field for Implantable Drug Delivery

“…Implantable drug delivery systems can provide localized drug release in precisely controlled, patient-specific time sequences with a single administration . By now, various kinds of drug delivery implants have been successfully developed for the treatment of chronic pain, , osteoporosis, retinal diseases, ovarian cancer, prostate cancer, and brain tumor . However, most of the existing implants need to be removed surgically after the treatment period or replaced after the device’s lifetime, which leads to additional costs, secondary injuries, and higher risks of postsurgical complications such as inflammation, infection, and pain.…”

Advances in intrathecal drug delivery

“…Hoelzer et al [27] report meningismus following intrathecal catheter placement with presentation similar to postdural puncture headache and meningitis. The symptoms were found to be due to malpositioned intraspinal catheter tip approximated to the meninges.…”