Meningioma: A Pathology Perspective

Toland, Angus; Huntoon, Kristin; Dahiya, Sonika

doi:10.1093/neuros/nyab001

Cited by 14 publications

(23 citation statements)

References 133 publications

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“…[91] It is currently considered that the coexistence of TRAF7 and PIK3CA mutations indicates long-term recurrence of skull base meningiomas. [86,92] Youngblood et al [53] reported a multi-center retrospective clinical study with 469 meningioma samples in 2021, which found that meningiomas harboring TRAF7 mutation were more prone to recurr within 2 years. Mutations in TRAF7 are mutually exclusive of NF2 mutations but often have a concomitant mutation in AKT1 or KLF4.…”

Section: Smo and Sufu Mutations In The Hedgehog Pathwaymentioning

confidence: 99%

Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Deng

Hua

Bian

et al. 2022

Chinese Medical Journal

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Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations. The fifth edition of the WHO Classification of Tumors of the Central Nervous System (WHO CNS5), published in 2021, introduces major changes that advance the role of molecular diagnostics in meningiomas. To follow the revision of WHO CNS5, this expert consensus statement was formed jointly by the Group of Neuro-Oncology, Society of Neurosurgery, Chinese Medical Association together with neuropathologists and evidence-based experts. The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients.Registration:Practice guideline REgistration for transPAREncy (PREPARE), IPGRP-2022CN234

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Section: Smo and Sufu Mutations In The Hedgehog Pathwaymentioning

confidence: 99%

Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Deng

Hua

Bian

et al. 2022

Chinese Medical Journal

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“…Psammoma bodies can be seen in many cases where meningioma cells form a whorled pattern surrounding calcified tissue. Certain genetic syndromes such as neurofibromatosis type 2 (NF2), PTEN syndrome, and Gorlin syndrome have been associated as risk factors for developing meningiomas [ 14 ].…”

Section: Extramedullary Tumorsmentioning

confidence: 99%

Characterization and Treatment of Spinal Tumors

2022

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The prevalence of spinal tumors is rare in comparison to brain tumors which encompass most central nervous system tumors. Tumors of the spine can be divided into primary and metastatic tumors with the latter being the most common presentation. Primary tumors are subdivided based on their location on the spinal column and in the spinal cord into intramedullary, intradural extramedullary, and primary bone tumors. Back pain is a common presentation in spine cancer patients; however, other radicular pain may be present. Magnetic resonance imaging (MRI) is the imaging modality of choice for intradural extramedullary and intramedullary tumors. Plain radiographs are used in the initial diagnosis of primary bone tumors while Computed tomography (CT) and MRI may often be necessary for further characterization. Complete surgical resection is the treatment of choice for spinal tumors and may be curative for well circumscribed lesions. However, intralesional resection along with adjuvant radiation and chemotherapy can be indicated for patients that would experience increased morbidity from damage to nearby neurological structures caused by resection with wide margins. Even with the current treatment options, the prognosis for aggressive spinal cancer remains poor. Advances in novel treatments including molecular targeting, immunotherapy and stem cell therapy provide the potential for greater control of malignant and metastatic tumors of the spine.

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“…На основі жіночої схильності, збільшення розмірів пухлин під час вагітності та експресії рецепторів прогестерону були висунуті гіпотези про роль гормонів у патогенезі менінгіом. Дані маркери найчастіше застосовуються для діагностики, проте мають неоптимальну чутливість і специфічність [29][30].…”

Section: результати та їх обговорення поширеність класифікація та клі...unclassified

Bibliometric Analysis of the Scientific Literature on Meningiomas With Calcification

Denysenko

Moskalenko

2022

EUMJ

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Meningiomas are the most common non-glial tumours of the central nervous system characterized by pathological biomineralization. The work aimed to conduct bibliometric analysis and systematize data on the prevalence, etiology, morphology and main trends in the study of meningiomas with calcification. The authors searched for information on meningiomas in electronic databases such as PubMed, Scopus, Web of Science and Google Scholar for the past 25 years by the key terms such as meningiomas, calcifications, and psammoma bodies. For bibliometric analysis, the authors used an online platform to monitor and analyze international research using visualization tools and modern citation metrics SciVal (Scopus) and a tool for building and visualizing bibliometric networks VOSviewer. Pathological biomineralization is manifested through the formation of psammoma bodies, and the main mineral component is calcium hydroxyapatite. Although calcification is likely to play a protective role and be a favourable prognostic feature, it should be considered when choosing surgical tactics. There is also the problem of closing the defects of the dura mater with the help of biological and synthetic transplants. According to the bibliometric analysis of scientific literature on meningiomas and the phenomena of pathological biomineralization in them, we found that the number of publications on this topic had increased significantly over the past five years, the leading countries of origin are the United States, Japan and China. When researching the array of Scopus database publications using SciVal tools, the problem of meningioma calcification was divided into 61 topics and 24 thematic clusters, the vast majority of which belonged to medicine and biology and materials science. According to the results of bibliometric analysis of 678 publications in the Scopus database by keywords "calcification" and "meningioma", they can be divided into seven thematic clusters and four chronological stages. Despite the prevalence of meningioma calcification, there is currently no fundamental idea of the etiology and pathogenesis of this process. Studying the morphological features of meningiomas with calcification can help improve the diagnosis and treatment of the central nervous system tumours.

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Meningioma: A Pathology Perspective

Cited by 14 publications

References 133 publications

Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Characterization and Treatment of Spinal Tumors

Bibliometric Analysis of the Scientific Literature on Meningiomas With Calcification

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