Meningeal Tumors of Childhood and Infancy. An Update and Literature Review.

Abstract

Meningeal derived tumors of the first 2 decades of life are often diagnostically challenging due to the wide morphologic spectrum encountered and the rarity of most individual entities. The 2 most common patterns include the dural/leptomeningeal‐based mass and neoplastic meningitis. Both primary and secondary meningeal presentations may occur, either early or late in the course of various meningothelial, mesenchymal, embryonal, glial, hematopoietic, histiocytic, melanocytic, and inflammatory tumors. As in other areas of pediatric pathology, there are significant differences between this patient cohort and adults, differences which will be emphasized in this review.

Meningiomas in Children

“…Children with meningiomas present late in the first decade of life or early in the second [4, 7, 8]. The median age at presentation in this series was 13 years of age.…”

“…Modan et al[ 6] studied 11,000 children who had been irradiated for tinea capitis and found a fourfold increased risk of meningioma. The prevalence of NF-2 in pediatric patients with meningioma has been shown to be 25–40% [1, 2,7,8,9,10]. Patients with spontaneously arising meningiomas appear to have tumors distinct from those with radiation-induced meningiomas or those associated with NF-2, in that those patients with spontaneously arising meningiomas were younger at the time of diagnosis, were more likely to be female, and had tumors that were more likely to recur and to be malignant.…”

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

“…They comprise only 0.4–4.1% of all pediatric age tumors and only 1.5–1.8% of all intracranial neoplasms in children [1]. In the literature, large series of pediatric meningiomas are uncommon and only a few studies have attempted to analyze the characteristics of these neoplasms in children and the biological differences in comparison to the adult counterparts [1,2,3,4]. We retrospectively analyzed the clinical, pathological and management profile of these tumors.…”

Does Transitional Type of Meningioma Indicate Recurrence Risk Alone?: A Case Report

“…Meningiomaların büyük bölümü araknoid villuslardan ve kraniyospinal boşluktaki araknoid membrandaki dağınık gruplar halinde bulunan meningotelyal (araknoidal) hücrelerden kaynaklanır. Çok azı ise dural fibroblastlar, koroid pleksus ve kranyal sinirlerin çev-resindeki araknoidden gelişir (8). Tüm intrakraniyal tümörlerin yaklaşık %13 -26'sını oluştururlar.…”