Ménage à trois: Borrelia, dendritic cells, and tick saliva interactions

Mason, Lauren M.K.; Veerman, Christiaan C.; Geijtenbeek, Teunis B. H.; Hovius, Joppe W.

doi:10.1016/j.pt.2013.12.003

Cited by 47 publications

(30 citation statements)

References 91 publications

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“…Several studies suggest that there are interactions between tick saliva and DCs [70–72]. For a review of the interactions between DCs, tick saliva, and Borrelia , see [73]. …”

Section: Dendritic Cells and Tick Salivamentioning

confidence: 99%

Modulation of host immunity by tick saliva

Kotál

Langhansová

Lieskovská

et al. 2015

Journal of Proteomics

176

183

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Next generation sequencing and proteomics have helped to comprehensively characterize gene expression in tick salivary glands at both the transcriptome and the proteome level. Functional data are, however, lacking. Given that tick salivary secretions are critical to the success of the tick transmission lifecycle and, as a consequence, for host colonization by the pathogens they spread, we thoroughly review here the literature on the known interactions between tick saliva (or tick salivary gland extracts) and the innate and adaptive vertebrate immune system. The information is intended to serve as a reference for functional characterization of the numerous genes and proteins expressed in tick salivary glands with an ultimate goal to develop novel vector and pathogen control strategies.

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“…Several studies suggest that there are interactions between tick saliva and DCs [70–72]. For a review of the interactions between DCs, tick saliva, and Borrelia , see [73]. …”

Section: Dendritic Cells and Tick Salivamentioning

confidence: 99%

Modulation of host immunity by tick saliva

Kotál

Langhansová

Lieskovská

et al. 2015

Journal of Proteomics

176

183

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“…are recognized by several mechanisms of the immune response, including the complement system and diverse innate immune cells 17 . Despite being classified as gram negative, B. burgdorferi does not produce lipopolysaccharide (LPS) but does express OspC in vertebrates.…”

Section: Immune Responsementioning

confidence: 99%

“…Following antigen presentation by dendritic cells, T H 1 and T H 2 lymphocyte helper T cells initiate the adaptive response, promoting the release of interferon IFN-γ and interleukin IL-4, which are directly related to the severity of acute symptoms 17 . Subsequently, the cytokines released by T H cells induce B-lymphocyte proliferation of and consequently, immunoglobulin production 18 …”

Section: Immune Responsementioning

confidence: 99%

Brazilian borreliosis with special emphasis on humans and horses

Basile

Yoshinari

Mantovani

et al. 2017

Brazilian Journal of Microbiology

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Borreliosis caused by Borrelia burgdorferi sensu lato is a cosmopolitan zoonosis studied worldwide; it is called Lyme disease in many countries of the Northern Hemisphere and Lyme-like or Baggio-Yoshinari Syndrome in Brazil. However, despite the increasing number of suspect cases, this disease is still neglected in Brazil by the medical and veterinary communities. Brazilian Lyme-like borreliosis likely involves capybaras as reservoirs and Amblyomma and Rhipicephalus ticks as vectors. Thus, domestic animals can serve as key carriers in pathogen dissemination. This zoonosis has been little studied in horses in Brazil. The first survey was performed in the state of Rio de Janeiro, and this Brazilian Borreliosis exhibits many differences from the disease widely described in the Northern Hemisphere. The etiological agent shows different morphological and genetic characteristics, the disease has a higher recurrence rate after treatment with antibiotics, and the pathogen stimulates intense symptoms such as a broader immune response in humans. Additionally, the Brazilian zoonosis is not transmitted by the Ixodes ricinus complex. With respect to clinical manifestations, Baggio-Yoshinari Syndrome has been reported to cause neurological, cardiac, ophthalmic, muscle, and joint alterations in humans. These symptoms can possibly occur in horses. Here, we present a current panel of studies involving the disease in humans and equines, particularly in Brazil.

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“…DCs are enriched in early Lyme disease skin lesions ( erythema migrans ) (Salazar et al, 2003) and are amongst the first immune cells to come into contact with Bb in the skin (Mason et al, 2014). Phagocytosis of Bb activates DCs by inducing expression of CD83 and upregulating expression of CD40, CD80, CD86, and HLA-DR (Suhonen et al, 2003) and lead to increased transcription of proinflammatory cytokines, including IL-6, IL-1β, and TNF-α (Petzke et al, 2009).…”

Section: B Burgdorferi Infection and The Innate Immune Responsementioning

confidence: 99%

“…The PMN chemotactic factor IL-8 (Dennis et al, 2006), as well as a number of other PMN chemoattractants (Hartiala et al, 2007) are produced by DCs following Bb infection. Upon contact with Bb in the skin, DCs migrate to the lymph nodes where they present antigens to T cells and induce adaptive immune responses (Mason et al, 2014). Similarly to Bb-stimulated macrophages, IL-10 is also elicited from Bb-infected DCs (Chung et al, 2013).…”

Section: B Burgdorferi Infection and The Innate Immune Responsementioning

confidence: 99%

Phagosomal TLR signaling upon Borrelia burgdorferi infection

Cervantes

Hawley

Benjamin

et al. 2014

FCIMB

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Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.

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Ménage à trois: Borrelia, dendritic cells, and tick saliva interactions

Cited by 47 publications

References 91 publications

Modulation of host immunity by tick saliva

Modulation of host immunity by tick saliva

Brazilian borreliosis with special emphasis on humans and horses

Phagosomal TLR signaling upon Borrelia burgdorferi infection

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