2014
DOI: 10.1016/j.pt.2013.12.003
|View full text |Cite
|
Sign up to set email alerts
|

Ménage à trois: Borrelia, dendritic cells, and tick saliva interactions

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
30
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
5
3

Relationship

0
8

Authors

Journals

citations
Cited by 47 publications
(30 citation statements)
references
References 91 publications
0
30
0
Order By: Relevance
“…Several studies suggest that there are interactions between tick saliva and DCs [70–72]. For a review of the interactions between DCs, tick saliva, and Borrelia , see [73]. …”
Section: Dendritic Cells and Tick Salivamentioning
confidence: 99%
“…Several studies suggest that there are interactions between tick saliva and DCs [70–72]. For a review of the interactions between DCs, tick saliva, and Borrelia , see [73]. …”
Section: Dendritic Cells and Tick Salivamentioning
confidence: 99%
“…are recognized by several mechanisms of the immune response, including the complement system and diverse innate immune cells 17 . Despite being classified as gram negative, B. burgdorferi does not produce lipopolysaccharide (LPS) but does express OspC in vertebrates.…”
Section: Immune Responsementioning
confidence: 99%
“…Following antigen presentation by dendritic cells, T H 1 and T H 2 lymphocyte helper T cells initiate the adaptive response, promoting the release of interferon IFN-γ and interleukin IL-4, which are directly related to the severity of acute symptoms 17 . Subsequently, the cytokines released by T H cells induce B-lymphocyte proliferation of and consequently, immunoglobulin production 18 …”
Section: Immune Responsementioning
confidence: 99%
“…DCs are enriched in early Lyme disease skin lesions ( erythema migrans ) (Salazar et al, 2003) and are amongst the first immune cells to come into contact with Bb in the skin (Mason et al, 2014). Phagocytosis of Bb activates DCs by inducing expression of CD83 and upregulating expression of CD40, CD80, CD86, and HLA-DR (Suhonen et al, 2003) and lead to increased transcription of proinflammatory cytokines, including IL-6, IL-1β, and TNF-α (Petzke et al, 2009).…”
Section: B Burgdorferi Infection and The Innate Immune Responsementioning
confidence: 99%
“…The PMN chemotactic factor IL-8 (Dennis et al, 2006), as well as a number of other PMN chemoattractants (Hartiala et al, 2007) are produced by DCs following Bb infection. Upon contact with Bb in the skin, DCs migrate to the lymph nodes where they present antigens to T cells and induce adaptive immune responses (Mason et al, 2014). Similarly to Bb-stimulated macrophages, IL-10 is also elicited from Bb-infected DCs (Chung et al, 2013).…”
Section: B Burgdorferi Infection and The Innate Immune Responsementioning
confidence: 99%