Men B: lack of coverage or vaccine failure?

Bayliss, Christopher D.; Morrissey, Julie A.; Borrow, Ray

doi:10.1016/s0140-6736(16)00218-x

Cited by 3 publications

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References 3 publications

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“…A major limitation of MATS for assessing 4C-MenB coverage is lack of applicability to invasive disease cases where confirmation is achieved by PCR only, without strain isolation [ 15 ]. Following introduction of 4C-MenB into the UK national infant immunisation schedule [ 16 ], development of non-culture based assays are critical for assessing coverage for the ~50% of cases confirmed by PCR alone [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines

et al. 2018

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Factor H binding protein (fHbp) is a major protective antigen in 4C-MenB (Bexsero®) and Trumenba®, two serogroup B meningococcal vaccines, wherein expression level is a determinant of protection. Examination of promoter-containing intergenic region (IGR) sequences indicated that nine fHbp IGR alleles covered 92% of 1,032 invasive meningococcal strains with variant 1 fHbp alleles. Relative expression values for fHbp were determined for 79 meningococcal isolates covering ten IGR alleles by quantitative reverse transcriptase polymerase chain reaction (qRT PCR). Derivation of expression clusters of IGR sequences by linear regression identified five expression clusters with five nucleotides and one insertion showing statistically associations with differences in expression level. Sequence analysis of 273 isolates examined by the Meningococcal Antigen Typing Scheme, a sandwich ELISA, found that coverage depended on the IGR expression cluster and vaccine peptide homology combination. Specific fHbp peptide-IGR expression cluster combinations were designated as ‘at risk’ for coverage by 4C-MenB and were detected in multiple invasive meningococcal disease cases confirmed by PCR alone and occurring in partially-vaccinated infants. We conclude that sequence-based analysis of IGR sequences is informative for assessing protein expression and has utility for culture-independent assessments of strain coverage by protein-based vaccines.

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Section: Introductionmentioning

confidence: 99%

Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines

et al. 2018

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A retrospective assessment of the completeness and timeliness of meningococcal disease notifications in the Republic of Ireland over a 16-year period, 1999–2015

et al. 2018

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Does post-implementation vaccine effectiveness data support pre-implementation predictions of 4CMenB utility?

Findlow¹,

Borrow²

2017

Pathogens and Disease

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Meningococcal serogroup B vaccines have been licensed on the basis of safety and immunogenicity data without efficacy studies. Establishing the breadth of coverage of these new vaccines has proved difficult and relied on correlates of protection such as serum bactericidal antibody and a novel assays such as the meningococcal antigen typing system. The demonstration of the effectiveness of 4CMenB in a reduced infant dose schedule together with detailed phenotypic and genotypic information gained from isolates and sera from cases of invasive MenB disease in vaccine eligible infants will enable a re-evaluation of our knowledge of correlates of protection. This review includes how the utility of 4CMenB was estimated and key considerations that were taken.

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Men B: lack of coverage or vaccine failure?

Cited by 3 publications

References 3 publications

Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines

Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines

A retrospective assessment of the completeness and timeliness of meningococcal disease notifications in the Republic of Ireland over a 16-year period, 1999–2015

Does post-implementation vaccine effectiveness data support pre-implementation predictions of 4CMenB utility?

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