A retrospective assessment of the completeness and timeliness of meningococcal disease notifications in the Republic of Ireland over a 16-year period, 1999–2015

O’Lorcain, P.; Bennett, Désirée E.; Morgan, Sophia; Cunney, Robert; Cotter, Suzanne; Cafferkey, Mary T.; O’Flanagan, D

doi:10.1016/j.puhe.2017.11.027

Cited by 10 publications

(17 citation statements)

References 17 publications

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“…those diagnosed by all non-culture methods). Data comparison with the national computerised infectious disease reporting (CIDR) system, which contains records of all confirmed and suspected cases of IMD notified in the RoI since January 1999, indicated that the vast majority of isolates that are recovered from patients with IMD are actually submitted to the IMSRL [6]. Furthermore, the proportion of cases from which an isolate was recovered was broadly in line with figures described for culture positive cases in the UK for 2009 and 2010 [73].…”

Section: Discussionsupporting

confidence: 53%

“…Over the 19 EYs, the meningococcal population structure associated with IMD in the RoI changed, as despite the lower numbers of isolates received/IMD cases reported each year, an overall increase in genotypic diversity was observed. The predominance of a single STcc has waned in recent years supporting the more sporadic nature of IMD in the RoI [6]. All or at least the vast majority of IMD cases from which an isolate was received over the study period were notified as sporadic with the exception of two isolates from cases that were epidemiologically linked but were recovered in two separate EY [63].…”

Section: Discussionmentioning

confidence: 91%

“…The objective of this study was to examine the diversity of IMD-associated isolates recovered in the RoI over 19 EYs, since the Irish Meningitis and Sepsis Reference Laboratory (IMSRL) was formally established in October 1996. This timespan includes a period of disease hyperendemicity during the mid-late 1990s (when the levels of disease due to menC were at their highest) up until the end of EY2014/2015 [6]. As part of national surveillance of IMD in RoI, all primary hospital diagnostic laboratories are requested to submit isolates of meningococci recovered from cases of IMD, irrespective of isolation site and clinical presentation, to the IMSRL for confirmation of identity and for epidemiological typing using capsular sero/ genogroup, PorB serotype and PorA serosubtype and genotyping (sequence type clonal complex distribution).…”

Section: Introductionmentioning

confidence: 99%

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Diversity of meningococci associated with invasive meningococcal disease in the Republic of Ireland over a 19 year period, 1996-2015

et al. 2020

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This study examined the capsular phenotype and genotype of invasive meningococcal disease (IMD)-associated Neisseria meningitidis recovered in the Republic of Ireland (RoI) between 1996 and 2015. This time period encompasses both pre-(when IMD was hyperendemic in the RoI) and post-meningococcal serogroup C conjugate (MCC) vaccine introduction. In total, 1327 isolates representing over one-third of all laboratory-confirmed cases of IMD diagnosed each epidemiological year (EY), were characterised. Serogroups B (menB) and C (menC) predominated throughout, although their relative abundance changed; with an initial increase in the proportion of menC in the late 1990s followed by their dramatic reduction post-MCC vaccine implementation and a concomitant dominance of menB, despite an overall decline in IMD incidence. While the increase in menC was associated with expansion of specific clonal-complexes (cc), cc11 and cc8; the dominance of menB was not. There was considerable variation in menB-associated cc with declines in cc41/44 and cc32, and increases in cc269 and cc461, contributing to a significant increase in the clonal diversity of menB isolates over the study. This increase in diversity was also displayed among the serosubtyping data, with significant declines in proportions of menB isolates expressing p1.4 and p1.15 antigens. These data highlight the changing diversity of IMDassociated meningococci since 1996 in the RoI and emphasise the need for ongoing surveillance particularly in view of the recent introduction of a menB vaccine.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Diversity of meningococci associated with invasive meningococcal disease in the Republic of Ireland over a 19 year period, 1996-2015

et al. 2020

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“…The 87% of cases that is reported in both databases is high compared with some comparable studies from other European countries with similar IMD surveillance systems. In an Irish study, looking at the surveillance data from 1999 to 2015, for 83% of all unique records a link could be made between the disease reporting system and the laboratory surveillance system [7]. From the disease reporting database, 87% of the cases were also reported in the laboratory database, from the laboratory database 94% of the cases were also reported in the disease reporting database.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004–2016

et al. 2019

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Background Enhanced surveillance for confirmed cases of invasive meningococcal disease (IMD) was introduced in the Netherlands in 2003, in which reference laboratory data (NRLBM) are linked with notification data (OSIRIS). The quality of surveillance information is important for public health decision making. Our objective was to describe the system and evaluate it for data completeness and timeliness. Methods Cases reported in the surveillance system from 2004 to 2016 were included. For the notification data, we used information on serogroup, vaccination status, mortality, and country of infection as indicators for record completeness. Notification times to regional and national level were calculated using the reported dates available in the notification database. Results A total of 2123 cases were reported in the years 2004–2016, of which 1.968 (93%) were reported by the reference laboratory and 1.995 (94%) in the notification system. Of all cases, 1.840 cases (87%) were reported in both systems and could be linked. The serogroup was known in 86% of the notified cases, and was significantly higher (94%) in the years 2013–2016. Information on vaccination status, mortality and country of infection was available in 88, 99 and 97% of notified cases, respectively. Regional notification of cases occurred within one working day for 86% of cases and 98% were notified nationally within three days. Conclusions A well performing IMD surveillance system was demonstrated and serogroup completeness has improved over the years. Underlining the need for reporting to both the clinical and laboratory surveillance system remains important to further improve the overall performance in supporting public health response and vaccination policy.

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“…The 87% of cases that is reported in both databases is high compared with some comparable studies from other European countries with similar IMD surveillance systems. In an Irish study, looking at the surveillance data from 1999 to 2015, for 83% of all unique records a link could be made between the disease reporting system and the laboratory surveillance system (5). From the disease reporting database, 87% of the cases were also reported in the laboratory database, from the laboratory database 94% of the cases were also reported in the disease reporting database.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004 – 2016

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Ende

Ruijs

et al. 2019

Preprint

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Background Enhanced surveillance for confirmed cases of invasive meningococcal disease (IMD) was introduced in the Netherlands in 2003, in which reference laboratory data (NRLBM) are linked with notification data (OSIRIS). The quality of surveillance information is important for public health decision making. Our objective was to describe the system and evaluate it for data completeness and timeliness. Methods Cases reported in the surveillance system from 2004 to 2016 were included. For the notification data, we used information on serogroup, vaccination status, mortality, and country of infection as indicators for record completeness. Notification times to regional and national level were calculated using the reported dates available in the notification database.  Results A total of 2,123 cases were reported in the years 2004-2016, of which 1.968 (93%) were reported by the reference laboratory and 1.995 (94%) in the notification system. Of all cases, 1.840 cases (87%) were reported in both systems and could be linked. The serogroup was known in 86% of the notified cases, and was significantly higher (94%) in the years 2013-2016. Information on vaccination status, mortality and country of infection was available in 88%, 99% and 97% of notified cases, respectively. Regional notification of cases occurred within one working day for 86% of cases and 98% were notified nationally within three days.  Conclusions A well performing IMD surveillance system was demonstrated and serogroup completeness has improved over the years. Underlining the need for reporting to both the clinical and laboratory surveillance system remains important to further improve the overall performance in supporting public health response and vaccination policy.

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A retrospective assessment of the completeness and timeliness of meningococcal disease notifications in the Republic of Ireland over a 16-year period, 1999–2015

Cited by 10 publications

References 17 publications

Diversity of meningococci associated with invasive meningococcal disease in the Republic of Ireland over a 19 year period, 1996-2015

Diversity of meningococci associated with invasive meningococcal disease in the Republic of Ireland over a 19 year period, 1996-2015

Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004–2016

Evaluation of the surveillance system for invasive meningococcal disease (IMD) in the Netherlands, 2004 – 2016

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