MEMS impedance flow cytometry designs for effective manipulation of micro entities in health care applications

“…There is growing interest in using CBI instruments due to their advantages and ability to perform real-time label-free analysis [27,34,38,69,70]. In the last few years, several novel strategies have been introduced to study cancer cell behavior using the CBI [52,[71][72][73][74][75].…”

Section: Cancer Researchmentioning

confidence: 99%

Recent Advances in Monitoring Cell Behavior Using Cell-Based Impedance Spectroscopy

2020

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Cell-based impedance spectroscopy (CBI) is a powerful tool that uses the principles of electrochemical impedance spectroscopy (EIS) by measuring changes in electrical impedance relative to a voltage applied to a cell layer. CBI provides a promising platform for the detection of several properties of cells including the adhesion, motility, proliferation, viability and metabolism of a cell culture. This review gives a brief overview of the theory, instrumentation, and detection principles of CBI. The recent applications of the technique are given in detail for research into cancer, neurodegenerative diseases, toxicology as well as its application to 2D and 3D in vitro cell cultures. CBI has been established as a biophysical marker to provide quantitative cellular information, which can readily be adapted for single-cell analysis to complement the existing biomarkers for clinical research on disease progression.

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“…Its numerous applications to the highly sensitive sensors, the excellently reliable actuators, bridges, and switches have been extensively studied. [1][2][3][4] During the operation of MEMS, the pull-in instability will occur, [5][6][7][8][9] which should be avoided in practical applications. There are various methods in the literature to deal with the pull-in instability: Anjum et al 10 gave a systematical review on various analytical methods for MEMS systems, Anjum et al 11 showed that the variational iteration method is an efficient tool to the analysis of the periodicity of an N/MEMS, Ji-Huan He et al established a variational theory for MEMS systems, 12 Anjum et al applied Li-He's modification of the homotopy perturbation method with great success, 13 Rehman et al suggested a modified variational iteration method coupled with Laplace transform, 14 and Ji-Huan He et al discovered the pull-in plateau.…”

Section: Introductionmentioning

confidence: 99%

Dynamic behaviors for the graphene nano/microelectromechanical system in a fractal space

2023

Journal of Low Frequency Noise, Vibration and Active Control

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The microelectromechanical devices have triggered rocketing interest in various advanced technologies, that is, sensors, material science, and energy harvesting, and now the devices tend to a nanoscale size, making the technology much more attractive in both academic and industrial communities. This paper takes a graphene nano/microelectromechanical system as an example to study its dynamical property, which is the foundation for the optimal design and reliable operation. As the system is inextricably complex with singularity and zero conditions in a fractal space, the iteration perturbation method is used to obtain the periodic solution of the system. The results show clearly the low-frequency property of the system and pull-in instability; furthermore, the fractal dimension affects greatly the system’s dynamical property.

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MEMS impedance flow cytometry designs for effective manipulation of micro entities in health care applications

Cited by 32 publications

References 69 publications

Microfluidic flow cytometry for blood-based biomarker analysis

Microfluidic flow cytometry for blood-based biomarker analysis

Recent Advances in Monitoring Cell Behavior Using Cell-Based Impedance Spectroscopy

Dynamic behaviors for the graphene nano/microelectromechanical system in a fractal space

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