MEMS-Based Acetone Vapor Sensor for Non-Invasive Screening of Diabetes

Rabih, Almur Abdelkreem Saeed; Dennis, John Ojur; Ahmed, A. Y.; Khir, M. H. Md; Ahmed, Mawahib Gafare Abdalrahman; Idris, Ahmad Kamal; Mian, Muhammad Umer

doi:10.1109/jsen.2018.2870942

Cited by 32 publications

(17 citation statements)

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“…A mass sensitive Complementary-Metal-Oxide-Semiconductor Micro-Electro-Mechanical Systems (CMOS-MEMS) based breath acetone biosensor with detection limit down to 0.4 ppm has also been simulated at room temperature [123]. It was experimentally tested for concentration of breath acetone down to 0.05 ppm using a polyMEMS device [124]. In another development, the possibility of intergrating hierarchical ZnO nanostructure to CMOS-MEMS has been described [125].…”

Section: Mass Sensitive Breathe Acetone Biosensorsmentioning

confidence: 99%

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

et al. 2019

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Exhaled breath acetone has been identified as a diabetes biomarker for non-invasive diagnosis. Its detection using biosensors features has many advantages over the conventional means. This paper reviews the recent literature on the detection of exhaled breath acetone and acetone vapor of diabetic interest. The biosensors have been classified based on their transduction methods. The performance characteristics of the biosensors have been explored for comparison. The future trends are also highlighted.

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Section: Mass Sensitive Breathe Acetone Biosensorsmentioning

confidence: 99%

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

et al. 2019

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“…The selectivity of the PANI/chitosan-and the ternary composite-based SPR biosensors to acetone vapour was also investigated by examining the sensor response (SPR shift) to the common interfering vapours such as ethanol, methanol, and ammonia [79,80]. Figure 8(d) shows the selectivity of the two sensing layers to 10 ppm concentrations of acetone, ethanol, methanol, and ammonia vapours with their refractive index values estimated based on Arago-Biot mixing formula (equation 17).…”

Section: Journal Of Sensorsmentioning

confidence: 99%

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

et al. 2019

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PANI/chitosan composite and a ternary composite comprising of PANI, chitosan, and reduced graphene oxide have been successfully synthesised and characterised using FTIR and UV-VIS spectroscopy. Optical constants of the composites were extracted from the UV-VIS spectra. The extracted parameters were applied in the simulation of a surface plasmon resonance (SPR) biosensor functionalised with PANI/chitosan and ternary composites. The aim was to explore the applicability of the composite-based SPR sensor in the detection of low-concentration acetone vapour within the range of 1.8 ppm–5.0 ppm for diabetes monitoring and screening. The functionalization of the SPR sensor with the PANI/chitosan and the ternary composites shows promising application of the sensor in the detection of acetone vapour at a low concentration down to less than 0.5 ppm. The maximum sensitivity values of about 60 and 180 degree/refractive index change were observed for PANI/chitosan and ternary composite sensing layers, respectively, in comparison with the bare gold-based SPR which shows no response up to 10 ppm concentration of acetone vapour in air. In addition, the two sensing layers show good selectivity to acetone vapour compared to ethanol, methanol, and ammonia. The response in the case of ternary composite shows better linearity with a correlation coefficient of 1.0 compared to PANI/chitosan- and gold-based SPR layers with 0.9999 and 0.9997, respectively.

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“…Next, further mixtures can be performed to obtain the desired concentration. Most of the works published in the literature [ 12 , 16 , 18 , 26 , 27 , 28 , 29 , 30 ] use a similar gas injection system as the one depicted in Figure 5 to characterize resonator-based gas sensor. To the best of our knowledge, a detailed investigation into the impact of the gas flow phenomena (without considering any analyte–sensor adsorption nor chemical interaction) on the vibrating mechanical structure is not available.…”

Section: Experimental Setup and Resultsmentioning

confidence: 99%

Impact of Fluid Flow on CMOS-MEMS Resonators Oriented to Gas Sensing

Perelló-Roig

Verd

Bota

et al. 2020

Sensors

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Based on experimental data, this paper thoroughly investigates the impact of a gas fluid flow on the behavior of a MEMS resonator specifically oriented to gas sensing. It is demonstrated that the gas stream action itself modifies the device resonance frequency in a way that depends on the resonator clamp shape with a corresponding non-negligible impact on the gravimetric sensor resolution. Results indicate that such an effect must be accounted when designing MEMS resonators with potential applications in the detection of volatile organic compounds (VOCs). In addition, the impact of thermal perturbations was also investigated. Two types of four-anchored CMOS-MEMS plate resonators were designed and fabricated: one with straight anchors, while the other was sustained through folded flexure clamps. The mechanical structures were monolithically integrated together with an embedded readout amplifier to operate as a self-sustained fully integrated oscillator on a commercial CMOS technology, featuring low-cost batch production and easy integration. The folded flexure anchor resonator provided a flow impact reduction of 5× compared to the straight anchor resonator, while the temperature sensitivity was enhanced to −115 ppm/°C, an outstanding result compared to the −2403 ppm/°C measured for the straight anchored structure.

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MEMS-Based Acetone Vapor Sensor for Non-Invasive Screening of Diabetes

Cited by 32 publications

References 50 publications

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

A Review of Biosensors for Non-Invasive Diabetes Monitoring and Screening in Human Exhaled Breath

Enhanced Sensitivity of Surface Plasmon Resonance Biosensor Functionalized with Doped Polyaniline Composites for the Detection of Low-Concentration Acetone Vapour

Impact of Fluid Flow on CMOS-MEMS Resonators Oriented to Gas Sensing

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