Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice

Silva, Adriana L. da; Piato, Ângelo; Bardini, Simone; Netto, Carlos Alexandre; Nunes, Domingos Sávio; Elisabetsky, Elaine

doi:10.1016/j.jep.2004.07.019

Cited by 39 publications

(23 citation statements)

References 29 publications

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“…Meyer, which prevented memory damage caused by scopolamine, in a model similar to the one in the present study (Hsieh et al, 2000); of Ptychopetalum olacoides Benth. (Da Silva et al, 2004), which improved the recovery of evoked memory of old mice; and of Evolvulus alsinoides (L.) L., which also prevented the deficit caused by scopolamine in rats (Siripurapu et al, 2005). In the present study, the administration of the hydroalcoholic extract of TD at the doses of 100 and 500 mg/kg for 43 days did not inhibit the deficit induced by scopolamine, indicating that the extract might not have a cholinergic effect.…”

Section: Discussioncontrasting

confidence: 42%

Effects of a hydroalcoholic extract of Turnera diffusa Willd. ex Schult., Turneraceae, in tests for adaptogenic activity

Bezerra¹,

Mendes²,

Tabach³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The objective of the present study was to assess whether Turnera diffusa Willd. ex Schult., Turneraceae, (TD), plant known in popular medicine as tonic and aphrodisiac, has other effects that are characteristic of an adaptogen substance, such as improvement of the memory and reduction of the damage caused by stress. We carried out an initial screening to detect a possible toxicity of the plant. In that phase of the study we used tests of observational screening; evaluation of acute toxicity; measurement of motor activity and motor coordination, and sleeping time induced by pentobarbital, and observed that the extract presented low toxicity and no stimulant or depressant effect on the animals. We then performed specifi c tests for the evaluation of an adaptogen effect. TD did not protect the stomach of the animals from the formation of ulcers, neither did it alter the plasmatic levels of adrenocorticotropic hormone (ACTH) and corticosterone of the animals submitted to immobilization and cold. As regards the evaluation of memory in passive avoidance, TD did not inhibit scopolamine-induced amnesia. Additionally, the hydroalcoholic extract presented low antioxidant activity in vitro. In the models used, TD produced no changes in relation to a possible adaptogen effect.

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Section: Discussioncontrasting

confidence: 42%

Effects of a hydroalcoholic extract of Turnera diffusa Willd. ex Schult., Turneraceae, in tests for adaptogenic activity

Bezerra¹,

Mendes²,

Tabach³

et al. 2011

Rev. bras. farmacogn.

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“…It is a known fact that aging leads to a loss of neurons which, in turn, leads to a progressive reduction of the cognitive functions, a fact that can be observed experimentally in old animals and prevented or improved by the administration of some plants (Petkov et al, 1993;Galvão et al, 2002;Da Silva et al, 2004;Marques et al, 2004). However, there was no improvement in the T-maze learning time of the old animals treated with B. trimera or D. rugosa extracts when compared with old controls.…”

Section: Discussionmentioning

confidence: 90%

Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity

Mendes

Tabach

Carlini

2007

Phytotherapy Research

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Baccharis trimera (Asteraceae) and Davilla rugosa (Dilleniaceae) are used popularly as tonics, aphrodisiacs and for stomach ailments, among other uses. Hydroalcohol extracts of the aerial parts of both plants were investigated with regard to their chemical constitution and their pharmacological activity in tests that evaluate adaptogen activity. Alkaloids, flavonoids, saponins, polyphenols/tannins and coumarins were identified in both extracts, while lignans were found only in the extract of Davilla rugosa. This extract presented also a marked antioxidant activity and exerted a moderate antiulcer effect in rats submitted to cold immobilization stress. It did not, however, inhibit the increase in the levels of ACTH and corticosterone induced by stress. Moreover, the Davilla rugosa did not improve the physical performance of mice submitted to forced exercise and the learning time of old rats in the T-maze, neither did it reduce the blood viscosity of the old animals. Conversely, the Baccharis trimera extract only presented a moderate antioxidant activity, without any positive effect on the other tests. These results point to the absence of an adaptogen activity of Baccharis trimera, with some effects that could be related to such an activity as regards the Davilla rugosa.

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“…We reported that P. olacoides standardized ethanol extract (POEE), a standardized ethanol extract obtained from P. olacoides, possesses various CNS-relevant properties, including antioxidant (Siqueira et al 2007) and neuroprotective (Siqueira et al 2004) activities. Regarding cognition, we showed that POEE facilitates short-term and long-term memories (inhibitory avoidance and object recognition) in adult and aged mice (da Silva et al 2004. As a likely neurochemical correlate of POEE promnesic effects, we also reported in vitro and in vivo acetylcholinesterase inhibition for the same extract (Siqueira et al 2003(Siqueira et al , 2007.…”

Section: Introductionmentioning

confidence: 64%

MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a “brain tonic”

et al. 2008

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Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice

Cited by 39 publications

References 29 publications

Effects of a hydroalcoholic extract of Turnera diffusa Willd. ex Schult., Turneraceae, in tests for adaptogenic activity

Effects of a hydroalcoholic extract of Turnera diffusa Willd. ex Schult., Turneraceae, in tests for adaptogenic activity

Evaluation of Baccharis trimera and Davilla rugosa in tests for adaptogen activity

MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a “brain tonic”

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