Memory responses of natural killer cells

Geary, Clair D.; Sun, Joseph C.

doi:10.1016/j.smim.2017.08.012

Cited by 69 publications

(65 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is believed that the newly nascent transformed cells can be initially eliminated by the host immune system based on innate immunity and adaptive immunity, and the destroyed cells then release various tumour antigens, further stimulate adaptive immunity and activate T/B lymphocytes. Studies have shown that tumour lymphatic infiltration and better survivability of patients have a strong correlation, [23][24][25] suggesting that patients F I G U R E 4 Validation of external datasets. A, Expression distribution of 13 immune metagenes in 4 subtypes in the validation set; B, Gene expression score of the tumour stroma scores, the immune scores and the tumour purity in the validation set; C, Expression distribution of 8 immune checkpoint genes in 4 subtypes in the validation set.…”

Section: Discussionmentioning

confidence: 99%

Identification of immune‐enhanced molecular subtype associated with BRCA1 mutations, immune checkpoints and clinical outcome in ovarian carcinoma

Zheng

Gou

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Ovarian carcinoma has the highest mortality among the malignant tumours in gynaecology, and new treatment strategies are urgently needed to improve the clinical status of ovarian carcinoma patients. The Cancer Genome Atlas (TCGA) cohort were performed to explore the immune function of the internal environment of tumours and its clinical correlation with ovarian carcinoma. Finally, four molecular subtypes were obtained based on the global immune‐related genes. The correlation analysis and clinical characteristics showed that four subtypes were all significantly related to clinical stage; the immune scoring results indicated that most immune signatures were upregulated in C3 subtype, and the majority of tumour‐infiltrating immune cells were upregulated in both C3 and C4 subtypes. Compared with other subtypes, C3 subtype had a higher BRCA1 mutation, higher expression of immune checkpoints, and optimal survival prognosis. These findings of the immunological microenvironment in tumours may provide new ideas for developing immunotherapeutic strategies for ovarian carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Identification of immune‐enhanced molecular subtype associated with BRCA1 mutations, immune checkpoints and clinical outcome in ovarian carcinoma

Zheng

Gou

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…CD11b + CD27 À NK cells have been reported to show increased expression of CD62L, S1P 5 (sphingosine-1-phosphate receptor 5), CX 3 CR1, CXCR3, CXCR4 and CCR1. [6][7][8][9] Although both CD25 and CD69 were found only at steady-state levels in S. schenckii-infected mice, KLRG1 had its expression up-regulated more than twofold. Additionally, CX 3 CR1 is highly expressed and mainly found on KLRG1 + NK cells (considered fully mature CD11b + CD27 À cells) identifying an even later maturation stage shown to have impaired IFN-c production and cytotoxicity towards YAC-1 cells under cytokine stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 NK cell development from the earliest NK cell-committed precursor to functionally competent mature NK cells is a stepwise process that involves the sequential acquisition of a series of surface molecules. [6][7][8][9] However, our current understanding of NK cell biology in disease conditions comes almost entirely from the setting of tumours and viral infections, with data on NK cell modulation by fungal infections being preliminary at best. Additionally, murine NK cells can be further dissected into four distinct maturation stages defined by the differential surface expression of CD11b (a M integrin) and CD27 [a tumour necrosis factor (TNF) receptor family member], from the least to the most mature, as follow: CD11b À CD27 À ?…”

Section: Introductionmentioning

confidence: 99%

Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii

et al. 2018

View full text Add to dashboard Cite

Natural killer (NK) cells are one of the first cell types to enter inflammation sites and have been historically known as key effector cells against tumours and viruses; now, accumulating evidence shows that NK cells are also capable of direct in vitro activity and play a protective role against clinically important fungi in vivo. However, our understanding of NK cell development, maturation and activation in the setting of fungal infections is preliminary at best. Sporotrichosis is an emerging worldwide-distributed subcutaneous mycosis endemic in many countries, affecting humans and other animals and caused by various related thermodimorphic Sporothrix species, whose prototypical member is Sporothrix schenckii. We show that following systemic infection of BALB/c mice with S. schenckii sensu stricto, NK cells displayed a more mature phenotype as early as 5 days post-infection as judged by CD11b/CD27 expression. At 10 days post-infection, NK cells had increased expression of CD62 ligand (CD62L) and killer cell lectin-like receptor subfamily G member 1 (KLRG1), but not of CD25 or CD69. Depletion of NK cells with anti-asialo GM1 drastically impaired fungal clearance, leading to a more than eightfold increase in splenic fungal load accompanied by heightened systemic inflammation, as shown by augmented production of the pro-inflammatory cytokines tumour necrosis factor-α, interferon-γ and interleukin-6, but not interleukin-17A, in the spleen and serum. Our study is, to the best of our knowledge, the first to demonstrate that a fungal infection can drive NK cell maturation in vivo and that such cells are pivotal for in vivo protection against S. schenckii.

show abstract

“…A number of recent studies have concentrated on defining the extracellular and intracellular requirements for generating robust expansion of MCMV‐specific NK cells. Ly49H ligation (analogous to TCR engagement for T‐cell activation, “signal 1”) is required but not sufficient for optimal proliferation of Ly49H + NK cells, which also need costimulation (“signal 2”) and proinflammatory cytokine signaling (“signal 3”) . NK cell costimulation comes by way of the costimulatory molecule DNAX accessary molecule 1 (DNAM‐1), which interacts with its ligand poliovirus receptor (PVR or CD155) during MCMV infection .…”

Section: Waves Of Antiviral Immunitymentioning

confidence: 99%

Spatial and temporal coordination of antiviral responses by group 1 ILCs

Adams

Sun

2018

Immunological Reviews

Self Cite

View full text Add to dashboard Cite

Summary Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC1 responses that collectively serve to achieve optimal viral control.

show abstract

Memory responses of natural killer cells

Cited by 69 publications

References 119 publications

Identification of immune‐enhanced molecular subtype associated with BRCA1 mutations, immune checkpoints and clinical outcome in ovarian carcinoma

Identification of immune‐enhanced molecular subtype associated with BRCA1 mutations, immune checkpoints and clinical outcome in ovarian carcinoma

Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii

Spatial and temporal coordination of antiviral responses by group 1 ILCs

Contact Info

Product

Resources

About