Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats

Rao, Sanjay; Andrade, Chittaranjan; Reddy, K.R. Madhsudana; Madappa, K.N; Thyagarajan, Shivashanmugam; Chandra, Suresh R.

doi:10.1016/s0006-3223(01)01219-7

Cited by 39 publications

(25 citation statements)

References 13 publications

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“…Since inflammation can be damaging to host tissue, it was hypothesized that anti-inflammatory drugs might be inhibiting both the onset and the progression of Alzheimer's disease. This hypothesis is supported by the observation that indomethacin (NSAID) halted the progressive memory loss seen in Alzheimer's disease patients (Rao et al, 2002). Moreover, it has also been observed that elderly patients suffering from Alzheimer's disease showed reduction in symptoms of Alzheimer's disease upon chronic use of anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 85%

Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice

Joshi¹,

Parle²

2010

African Journal of Biomedical Research

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Section: Discussionmentioning

confidence: 85%

Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice

Joshi¹,

Parle²

2010

African Journal of Biomedical Research

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“…Neurobiological evidences are highlighting a strong link between neuroinflammation at hippocampus-entorhinal cortex, cingulate gyrus and nucleus basalis magnocellularis of brain areas and impairment of memory capacities (HaussWegrzyniak et al, 1999(HaussWegrzyniak et al, , 2000Marriott et al, 2002). Indomethacin, a non-steroidal anti-inflammatory drug exhibited a memory protective effect against electroconvulsive shock-induced retrograde amnesia and also against amyloid deposits in the brain (Rao et al, 2002;Stephan et al, 2003). Anti-inflammatory action of carbazole alkaloids present in Murraya koenigii leaves (Ramsewak et al, 1999) might also be contributing to the observed memory-enhancing activity of MKL in the present study.…”

Section: Discussionmentioning

confidence: 99%

Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYMurraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

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“…39 41) Indomethacin, a nonsteroidal antiin‰ammatory drug, exhibited a memory-protective eŠect against electroconvulsive shock-induced retrograde amnesia and also against amyloid deposits in the brain. 42,43) The antiin‰ammatory eŠect of E. o‹cinalis would act against the in‰ammatory component of the memory deˆcits. Furthermore, ‰avonoids from E. o‹cinalis were conformed to decrease cholesterol and triglycerides in the liver, heart, kidney, and aorta of rats, which may be responsible for the pronounced memory enhancing eŠect seen in aged rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Anwala Churna (Emblica officinalis GAERTN.): an Ayurvedic Preparation on Memory Deficit Rats

Mani¹,

Parle

2007

YAKUGAKU ZASSHI

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The present study was aimed at investigating the eŠects of Anwala churna (Emblica o‹cinalis GAERTN.), an Ayurvedic preparation, on memory in rats. Anwala churna was administered orally in three doses (50, 100 and 200 mg/kg) for 15 days to diŠerent groups of young and aged rats. The elevated plus-maze and Hebb-Williams maze served as exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-, and ageing induced amnesia served as the interoceptive behavioral models. Anwala churna (50, 100, and 200 mg/kg, p.o.) produced a dose-dependent improvement in memory scores of young and aged rats. Furthermore, it reversed the amnesia induced by scopolamine (0.4 mg/ kg, i.p.) and diazepam (1 mg/kg, i.p.). Based on these results, Anwala churna may prove to be a useful remedy for the management of Alzheimer's disease due to its multifarious beneˆcial eŠects such as memory improvement and reversal of memory deˆcits.

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Memory protective effect of indomethacin against electroconvulsive shock-induced retrograde amnesia in rats

Cited by 39 publications

References 13 publications

Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice

Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice

Nootropic Potential of Murraya koenigii leaves in Rats

Effect of Anwala Churna (Emblica officinalis GAERTN.): an Ayurvedic Preparation on Memory Deficit Rats

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