Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice

Abstract

Phyllanhus amarus (PAs) is commonly known as

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

“…Piracetam 400 mg/kg, i.p. was used as positive control (Joshi and Parle, 2007). Nootropic activity of [6]-gingerol and phyllanthin was studied in mice using elevated plus maze and passive avoidance paradigm.…”

The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies

“…Amongst the Yoruba (Southwest Nigeria), Igbo (Southeast Nigeria) and Asaba (Niger Delta) people, it is locally known as ''Iyin-Olobe'', ''ngwu'' and ''buchi oro'', respectively (Adeneye et al, 2006;Iranloye et al, 2011). Different extracts of the plant have been reported to be effective in the management of human diseases such as liver and renal stone diseases (Ott et al, 1997;Kiemer et al, 2003;Adeneye and Benebo, 2008), menstrual disorder, infections (Kokwaro, 1976), pain and inflammation (Kassuya et al, 2003;Iranloye et al, 2011), skin ulcers, typhoid fever (Iwu, 1993;Raphael et al, 2002), diabetes mellitus, hyperlipidemia and hypertension (Srividya and Periwal, 1995;Kaliwal et al, 2012) and anemia (Adeneye and Arogundade, 2007), cancers (Joy and Kuttan, 1998;Sripanidkulchai et al, 2002) and amnesia (Joshi and Parle, 2007).…”

Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats

“…However, pharmacological evaluation of Phyllanthus amarus extracts showed that the plant possesses antidiarrheal effect (Odetola and Akojenu, 2000), antiviral activity against hepatitis B virus (Ott et al, 1997), antimutagenic and anticarcinogenic activities (Joy and Kuttan, 1998;Rajeshkumar et al, 2002;Sripanidkulchai et al, 2002). Also, the plant's antinociceptive and anti-inflammatory activities (Kassuya et al, 2003), hypoglycemic and hypocholesterolemic effects (Adeneye et al, 2006), hematopoeitic and immuno-stimulatory activities (Adeneye and Arogundade, 2007) as well as its anti-amnesic potentials in mice (Joshi and Parle, 2007) are well documented in literature.…”

“…The plant is also used in the treatment of stomach disorders, skin diseases and cold (Kokwaro, 1976;Iwu, 1993). In India, the plant is reputed for treating hepatic and urolithic diseases (Joshi and Parle, 2007). However, pharmacological evaluation of Phyllanthus amarus extracts showed that the plant possesses antidiarrheal effect (Odetola and Akojenu, 2000), antiviral activity against hepatitis B virus (Ott et al, 1997), antimutagenic and anticarcinogenic activities (Joy and Kuttan, 1998;Rajeshkumar et al, 2002;Sripanidkulchai et al, 2002).…”