Memory impairment induced by different types of prolonged stress is dependent on the phase of the estrous cycle in female rats

Nascimento, Ezequiel Batista do; Dierschnabel, Aline Lima; Medeiros, André de Macêdo; Suchecki, Deborah; Silva, Regina H.; Ribeiro, Alessandra Mussi

doi:10.1016/j.yhbeh.2019.104563

Cited by 21 publications

(11 citation statements)

References 70 publications

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“…Similar to our results, previous studies have demonstrated no differences in the time in the open arms of the PMDAT between Ctr female and male rats (Ribeiro et al, 2010), even though the specific phase of the estrous cycle (Nascimento et al, 2019), or any manipulation (Becegato et al, 2021), appears to impact the anxiety levels of females in this task. Previous studies have shown increased exploration in the aversive arm of the PMDAT during learning and retrieval (training and test sessions, respectively) in adult female rats (Melo et al, 2012;Nascimento et al, 2019), suggesting retention deficit of the aversive stimulus expressed in an estrous phase-dependent manner.…”

Section: Discussionsupporting

confidence: 91%

Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring

Linhares

Meurer

Aquino

et al. 2022

Behavioural Pharmacology

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During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are usually the first-line treatment. However, fluoxetine can cross the placental barrier and affect fetuses, causing changes in serotonin levels early in life. Long-term effects in the brain circuits that control cognitive and emotional behavior are related to early fluoxetine exposure during development. In this study, we aimed to investigate whether fluoxetine exposure (10 mg/kg/day) from the 13th gestational day (GD13) to GD21 may lead to behavioral emotional-cognitive changes in male and female rat offspring approximately 90 days postnatally (~PN90). We have analyzed the performance of individuals in the open field and in the plus-maze discriminative avoidance task, which assesses anxiety and learning/memory processing behaviors. We have found that prenatal (GD13–GD21) exposure to fluoxetine strengthened aversive memory and induced higher anxiety levels in males, and quick extinction of aversive memory in females. Taken together, these results suggest that early exposure to fluoxetine impairs the basal state of anxiety and the cognitive functions of rats during adulthood, which may be in a sex-specific manner because males appear more susceptible than females.

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Section: Discussionsupporting

confidence: 91%

Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring

Linhares

Meurer

Aquino

et al. 2022

Behavioural Pharmacology

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“…Furthermore, women in the perimenopause stage frequently experience emotional changes, such as irritability, sadness, lack of motivation, fatigue and mood swings [ 7 , 8 ], and mild cognitive decline associated with perimenopause has also been reported [ 9 ]. These emotions significantly influence social cognitive processes, which in turn, influence life outcomes [ 10 , 11 ]. Thus, a better understanding of this life period, which every woman passes through, can be gained through the efforts of neuroscientists, including those in the biological and psychological sciences, to detect early-stage biomarkers of cognitive decline and work on the implications of brain oscillations.…”

Section: Introductionmentioning

confidence: 99%

Association between resting-state EEG oscillation and psychometric properties in perimenopausal women

Hwang

Hsu

et al. 2022

BMC Women's Health

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Background The perimenopausal period is associated with a higher risk of various mood disorders. Similarly, although resting-state electroencephalogram (rsEEG) brain oscillatory activity has been associated with various neuropsychological disorders and behaviours, these issues have not been assessed in perimenopausal women. This study aimed to evaluate quantitative relationships between psychometric properties and rsEEG rhythms (delta, theta, alpha, beta and gamma powers) in perimenopausal women. Methods A cross-sectional correlational descriptive study was conducted to quantitatively analyze the correlations between rsEEG low-to-high band activities (delta, theta, alpha, beta, and gamma powers) and psychometric properties in 14 perimenopausal women. Participants completed a psychological inventory comprising the State Anxiety Inventory (SAI), Depression Inventory (DI), Behavioural Inhibition Scale (BIS) and short-form UPPS Impulsive Behaviour Scale (IS) before EEG recording. Results Results showed that impulsivity was positively related to the beta power, symmetrical at most channels (frontal, temporal, central, parietal and occipital regions; p < .05); but did not related to the delta, theta, alpha and gamma powers. The brainwave low-to-high bands, delta, theta, alpha, beta and gamma power were not associated with DI, SAI or BIS scores. Conclusions This study’s findings propose that significantly enhanced resting-state beta activity is a trait of impulsivity in perimenopausal women. Therefore, results have potential implications for the preclinical or clinical evaluation of these issues in perimenopausal women.

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“…Emotional behavior varies throughout the estrous cycle (Frye et al., 2000; Frye & Walf, 2002; Marcondes et al., 2001). Females in estrous seem to be more resilient to the anxiogenic effect of chronic stress than in diestrus and metestrus (do Nascimento et al., 2019), possibly because progesterone levels are low in the latter (Lovick, 2012). It is worth mentioning, however, that sex differences in tone and context fear conditioning arise even in pre‐pubertal rats (Toledo‐Rodriguez & Sandi, 2007).…”

Section: Discussionmentioning

confidence: 99%

Early life stress alters emotional learning in a sex‐ and age‐dependent manner with no impact on emotional behaviors

Zanta

Suchecki

Girardi

2021

Developmental Psychobiology

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Neonatal adversity can impact neurodevelopmental trajectories. This study examined the long‐term effects of maternal deprivation on day 9 (DEP9), associated or not to a stressor (saline injection [SAL]), on contextual fear conditioning (Experiment 1) and emotional behaviors (Experiment 2) in Wistar rats. Whole litters were either assigned to DEP9 or control groups, and on day 10, half of the litters in each group received an SAL or not (NSAL). DEP9‐SAL male adolescents showed the longest freezing time and DEP9 adult males froze more than females. Females exhibited less anxiety‐like behavior than males; DEP9‐SAL females spent more time in the open arms and DEP9 males visited less the extremity of the open arm in the elevated plus maze. Early life stress increased conditioned and innate fear in males, but not in females, indicating a clear sexual dimorphism in the response to potentially threatening stimuli.

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Memory impairment induced by different types of prolonged stress is dependent on the phase of the estrous cycle in female rats

Cited by 21 publications

References 70 publications

Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring

Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring

Association between resting-state EEG oscillation and psychometric properties in perimenopausal women

Early life stress alters emotional learning in a sex‐ and age‐dependent manner with no impact on emotional behaviors

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