Memory impairment following right cerebellar infarction: a case study

Nakamoto, Fumiko Kusunoki; Tsutsumiuchi, Michiko; Maeda, Mitsuaki; Uesaka, Yoshikazu; Takeda, Kazuya

doi:10.1080/13554794.2014.969277

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…Single-photon emission computed tomography (SPECT) revealed insufficient perfusion in the right cerebellar hemisphere and the left frontotemporal area, including the left prefrontal lateral cortex, with slightly reduced perfusion in the left anterior thalamus. The authors suggested that the memory impairment was linked to the thalamus, which acts as a relay station in the complex network of cerebellar-brain connections (Nakamoto et al, 2015).…”

Section: Cerebellum and Working Memorymentioning

confidence: 99%

The cerebellum and cognitive neural networks

Zhang

Duan

Yu-xiang

et al. 2023

Front. Hum. Neurosci.

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Cognitive function represents a complex neurophysiological capacity of the human brain, encompassing a higher level of neural processing and integration. It is widely acknowledged that the cerebrum plays a commanding role in the regulation of cognitive functions. However, the specific role of the cerebellum in cognitive processes has become a subject of considerable scholarly intrigue. In 1998, Schmahmann first proposed the concept of “cognitive affective syndrome (CCAS),” linking cerebellar damage to cognitive and emotional impairments. Since then, a substantial body of literature has emerged, exploring the role of the cerebellum in cognitive neurological function. The cerebellum’s adjacency to the cerebral cortex, brainstem, and spinal cord suggests that the cerebral-cerebellar network loops play a crucial role in the cerebellum’s participation in cognitive neurological functions. In this review, we comprehensively examine the recent literature on the involvement of the cerebellum in cognitive functions from three perspectives: the cytological basis of the cerebellum and its anatomical functions, the cerebellum and cognitive functions, and Crossed cerebellar diaschisis. Our aim is to shed light on the role and mechanisms of the cerebellum in cognitive neurobrain networks.

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Section: Cerebellum and Working Memorymentioning

confidence: 99%

The cerebellum and cognitive neural networks

Zhang

Duan

Yu-xiang

et al. 2023

Front. Hum. Neurosci.

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“…The executive function deficits include short-term memory impairments and an inability to learn new information. Nakamoto et al (2015) reported an interesting case of a gentleman with a stroke in the cerebellar vermis and superior right cerebellum along with SPECT showing hypoperfusion of the right hemicerebellum and the left anterior thalamus. The individual developed episodic memory impairment with largely preserved working memory that eventually improved after 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Ischemia Presenting as Transient Global Amnesia

Morena

Kamdar

Adeli

2021

Cognitive and Behavioral Neurology

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Transient global amnesia (TGA) consists of acute-onset anterograde amnesia and typically resolves within 24 hours. Reported etiologies of TGA include transient ischemia to the hippocampus or thalamus, migraine, venous flow abnormalities, and epilepsy. There are no reports of cerebellar ischemia as an etiology of TGA. A 78-year-old woman with a medical history of diabetes presented to the Ohio State University ER after a period of anterograde amnesia lasting 3 hours. She was alert during the event, but asked the same questions repeatedly. Upon arrival to the ER, she was hypertensive but clinically back to baseline, with no recall of the 3-hour time period. An MRI of her brain revealed an isolated hyperintense signal on diffusion-weighted imaging (DWI) at the junction of the superior cerebellum and vermis, with apparent diffusion coefficient correlation. Vascular imaging of the brain and neck and a routine EEG were unremarkable. We diagnosed her with cerebellar ischemia presenting as TGA. She had no head injury, migraine, or history of epilepsy to suggest alternative etiologies of TGA. An increasing amount of literature has reported that the cerebellum is linked to the limbic system. A case series of SPECT imaging on individuals with TGA revealed transient cerebellar vermis hypoperfusion in addition to hippocampal DWI changes. We present what may be a novel report of isolated cerebellar ischemia presenting as TGA, and we add to the literature for clinicians to consider the possibility that damage to the cerebellum or its circuit to the cerebrum or thalamus can present as TGA.

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“…Actually, several functional neuroimaging studies have confirmed that the cerebellum, especially the PCL, plays an important role in higher‐order functions other than motor coordination and motor learning, including working memory (Durisko & Fiez, ; Hautzel, Mottaghy, Specht, Müller, & Krause, ), episodic memory (Fliessbach, Trautner, Quesada, Elger, & Weber, ; Spaniol et al, ), and executive functions (Stoodley, ; Stoodley & Schmahmann, ; Stoodley, Valera, & Schmahmann, ). Executive control, episodic memory, and linguistic abilities would be impaired if the PCL were damaged (Nakamoto, Tsutsumiuchi, Maeda, Uesaka, & Takeda, ; Schmahmann, ; Tamagni et al, ). In addition, the cerebellum shows age‐related declines in structural morphology and function, which lead to a decline in cognitive behaviors in older adults (Bernard & Seidler, ; Jacobs et al, ).…”

Section: Discussionmentioning

confidence: 99%

Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults

Zheng

Xiao

et al. 2018

PsyCh Journal

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Older adults demonstrate notable individual differences in associative memory. Here, resting-state functional magnetic resonance imaging (rsfMRI) was used to investigate whether intrinsic brain activity at rest could predict individual differences in associative memory among cognitively healthy older adults. Regional amplitude of low-frequency fluctuations (ALFF) analysis and a correlation-based resting-state functional connectivity (RSFC) approach were used to analyze data acquired from 102 cognitively normal elderly who completed the paired-associative learning test (PALT) and underwent fMRI scans. Participants were divided into two groups based on the retrospective self-reports on whether or not they utilized encoding strategies during the PALT. The behavioral results revealed better associative memory performance in the participants who reported utilizing memory strategies compared with participants who reported not doing so. The fMRI results showed that higher associative memory performance was associated with greater functional connectivity between the right superior frontal gyrus and the right posterior cerebellum lobe in the strategy group. The regional ALFF values in the right superior frontal gyrus were linked to associative memory performance in the no-strategy group. These findings suggest that the regional spontaneous fluctuations and functional connectivity during rest may subserve the individual differences in the associative memory in older adults, and that this is modulated by self-initiated memory strategy use.

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Memory impairment following right cerebellar infarction: a case study

Cited by 10 publications

References 19 publications

The cerebellum and cognitive neural networks

The cerebellum and cognitive neural networks

Cerebellar Ischemia Presenting as Transient Global Amnesia

Intrinsic spontaneous brain activity predicts individual variability in associative memory in older adults

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