Memory effects on the interfacial characteristics of dioctadecyldimethylammonium bromide monolayers at the air–water interface

Silva, Amélia M. Gonçalves da; Romão, Rute S.; Lucero, Ana; Patino, Juan M. Rodrı́guez

doi:10.1016/j.jcis.2003.11.002

Cited by 37 publications

(18 citation statements)

References 37 publications

(35 reference statements)

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“…2 it is clear that only DODAB possesses a transition region, which corresponds to a change from the liquid-expanded (LE) to the liquidcondensed (LC) state. The presence of the LE-LC phase transition for DODAB monolayers have also been reported by other authors [30,31,35].…”

Section: Resultssupporting

confidence: 82%

A study of the interaction between dialkyldimethylammonium bromides and tri-n-octylphosphine oxide (topo) in mixed monolayers at the air/water interface

Hąc-Wydro

Wydro

Dynarowicz-Łątka

2004

Journal of Colloid and Interface Science

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Section: Resultssupporting

confidence: 82%

A study of the interaction between dialkyldimethylammonium bromides and tri-n-octylphosphine oxide (topo) in mixed monolayers at the air/water interface

Hąc-Wydro

Wydro

Dynarowicz-Łątka

2004

Journal of Colloid and Interface Science

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“…They found for the equimolar mixed monolayer of a phosphatidylcholine and oleic acid a very low value of the excess Gibbs energy at zero pressure. Gonçalves da Silva et al, 2004;McConlogue and Vanderlick, 1997). Monolayers of DODAB and DPPC observed by BAM show similar topographies and morphologies.…”

Section: Binary Lipid Systemsmentioning

confidence: 81%

Mixed monolayers involving DPPC, DODAB and oleic acid and their interaction with nicotinic acid at the air–water interface

Silva¹,

Romão²

2005

Chemistry and Physics of Lipids

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“…The background was subtracted from each image; which was then corrected geometrically using image processing software (NDF). Each spread monolayer was compressed only once as the surface structure of the film was observed to vary slightly according to its history-as noted by previous workers [10]. However, repeated experiments were performed, each using a fresh monolayer to ensure that the images formed for a given system at a given surface pressure were reproducible.…”

Section: Brewster Angle Microscopymentioning

confidence: 99%

The effect of neutral helper lipids on the structure of cationic lipid monolayers

Dabkowska

Barlow

Hughes

et al. 2011

J. R. Soc. Interface.

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Successful drug delivery via lipid-based systems has often been aided by the incorporation of 'helper lipids'. While these neutral lipids enhance the effectiveness of cationic lipid-based delivery formulations, many questions remain about the nature of their beneficial effects. The structure of monolayers of the cationic lipid dimethyldioctadecylammonium bromide (DODAB) alone, and mixed with a neutral helper lipid, either diolelyphosphatidylethanolamine or cholesterol at a 1 : 1 molar ratio was investigated at the air -water interface using a combination of surface pressure -area isotherms, Brewster angle microscopy (BAM) and specular neutron reflectivity in combination with contrast variation. BAM studies showed that while pure DODAB and DODAB with cholesterol monolayers showed fairly homogeneous surfaces, except in the regions of phase transition, monolayers of DODAB with diolelyphosphatidylethanolamine were, in contrast, inhomogeneous exhibiting irregular bean-shaped domains throughout. Neutron reflectivity data showed that while the thickness of the DODAB monolayer increased from 17 to 24 Å as it was compressed from a surface pressure of 5 -40 mN m 21, the thickness of the helper lipid-containing monolayers, over the same range of surface pressures, was relatively invariant at between 25 and 27 Å . In addition, the monolayers containing diolelyphosphatidylethanolamine were found to be more heavily hydrated than the monolayers of cationic lipid, alone or in combination with cholesterol, with hydration levels of 18 molecules of water per molecule of lipid being recorded for the diolelyphosphatidylethanolamine-containing monolayers at a surface pressure of 30 mN m 21 compared with only six and eight molecules of water per molecule of lipid for the pure DODAB monolayer and the cholesterol-containing DODAB monolayer, respectively.

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Memory effects on the interfacial characteristics of dioctadecyldimethylammonium bromide monolayers at the air–water interface

Cited by 37 publications

References 37 publications

A study of the interaction between dialkyldimethylammonium bromides and tri-n-octylphosphine oxide (topo) in mixed monolayers at the air/water interface

A study of the interaction between dialkyldimethylammonium bromides and tri-n-octylphosphine oxide (topo) in mixed monolayers at the air/water interface

Mixed monolayers involving DPPC, DODAB and oleic acid and their interaction with nicotinic acid at the air–water interface

The effect of neutral helper lipids on the structure of cationic lipid monolayers

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