Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities

Petten, Cyma Van; Plante, Elena; Davidson, Patrick S. R.; Kuo, Trudy; Bajuscak, Leslie; Glisky, Elizabeth L.

doi:10.1016/j.neuropsychologia.2004.02.009

Cited by 194 publications

(176 citation statements)

References 90 publications

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“…So far, attempts at linking age-related structural alterations to executive functioning have yielded mixed results. Fjell et al [2006], Ziegler et al [2010], and Van Petten et al [2004] reported no correlation between cortical thickness and composite scores of various executive measures, whereas Kochunov et al [2009] found that thicker cortex in many regions was related to better executive performance in adults between 30 and 90 years, but not in adults between 19 and 26 years. These correlations, however, were no longer significant after controlling for age [Kochunov et al, 2009].…”

Section: Introductionmentioning

confidence: 97%

“…This might reflect relatively small sample sizes, ElderkinThompson et al, 2008, n ¼ 23;Gur et al, 1998, n ¼ 17;Sanfilipo et al, 2002, n ¼ 27, or stem from combining the WCST with other tests, whose neural substrates may not be overlapping [Van Petten et al, 2004]. In addition to issues regarding sample size and use of composite scores of executive functioning, the studies reporting negative results are affected by at least one of the following limitations: (a) use of volumetric measures, which confound cortical thickness, surface area, and folding [Im et al, 2006a,b]; a direct comparison of volumetric measures based on voxel-based morphometry and cortical thickness measures in 48 healthy adults aged 22-60 years revealed that volumetric measures were less sensitive, had lower signal-to-noise ratio, lower T-scores, and were more confounded by overall brain size than thickness measures [Hutton et al 2009]; (b) gross definition of frontal volume or frontal gyri, pooling together functionally dissociable areas, such as the dorsal and ventrolateral PFC, the orbitofrontal cortex, and premotor areas; and (c) investigation of frontal-lobe volume only, although the WCST is no longer considered a specific test of prefrontal function [Nyhus and Barcelo, 2009].…”

Section: Introductionmentioning

confidence: 99%

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Cortical thickness is linked to executive functioning in adulthood and aging

Burzyńska¹,

Nagel²,

Preuschhof³

et al. 2011

Human Brain Mapping

119

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Executive functions that are dependent upon the frontal-parietal network decline considerably during the course of normal aging. To delineate neuroanatomical correlates of age-related executive impairment, we investigated the relation between cortical thickness and executive functioning in 73 younger (20-32 years) and 56 older (60-71 years) healthy adults. Executive functioning was assessed using the Wisconsin Card Sorting Test (WCST). Cortical thickness was measured at each location of the cortical mantle using surface-based segmentation procedures on high-resolution T1-weighted magnetic resonance images. For regions involved in WCST performance, such as the lateral prefrontal and parietal cortices, we found that thicker cortex was related to higher accuracy. Follow-up ROI-based analyses revealed that these associations were stronger in older than in younger adults. Moreover, among older adults, high and low performers differed in cortical thickness within regions generally linked to WCST performance. Our results indicate that the structural cortical correlates of executive functioning largely overlap with previously identified functional patterns. We conclude that structural preservation of relevant brain regions is associated with higher levels of executive performance in old age, and underscore the need to consider the heterogeneity of brain aging in relation to cognitive functioning. Hum Brain Mapp 33:1607-1620,

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Cortical thickness is linked to executive functioning in adulthood and aging

Burzyńska¹,

Nagel²,

Preuschhof³

et al. 2011

Human Brain Mapping

119

View full text Add to dashboard Cite

show abstract

“…All research with human participants was reviewed and approved by the Duke University Institutional Review Board, and informed consent was obtained for all participants. 35,41,43,46,49,51,[55][56][57]. This decrease in parenchymal volume has generally been attributed to atrophy of gray matter [5,8,21,28,35,41,43,45,48; but see [23] for an exception], particularly cortical thinning [50], and may result from cell-body atrophy or the outright death of cells [44].…”

Section: Introductionmentioning

confidence: 99%

“…In many studies, the right hemisphere is found to be larger than the left [22,45,59,46]. For specific brain regions, this relation may not be as consistent, with some structures larger in the left hemisphere and others larger in the right [45,46,48,54,56,58]. Studies of the basal ganglia have been particularly contradictory; 2 studies report a larger right caudate [27,47] and 2 report a larger left caudate [20,25].…”

Section: Introductionmentioning

confidence: 99%

Aging, gender, and the elderly adult brain: An examination of analytical strategies

Greenberg¹,

Messer²,

Payne³

et al. 2008

Neurobiology of Aging

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We sought to examine the relations between age, gender and brain volumes in an elderly population; we also sought to examine ways of measuring these relations. Three sets of analyses were used: correlational analyses, in which correlations between independent variables and brain volumes were calculated without correction for intracranial volume (ICV); covariational analyses, in which ICV was used as a covariate in regression equations; and ratio analyses, in which the dependent variable was the ratio of brain volume to ICV. These analyses yielded similar results, except that (as expected) adjusting for ICV altered estimates of gender differences. Analyses of age showed decreases in left caudate, putamen, and right hippocampus and an increase in CSF, a result generally in accord with previous findings. However, we also found a significant decrease of white-matter volumes and no significant decrease in total gray-matter volumes. Correlational analyses showed that men did not always have larger volumes despite their larger head size; women generally had larger volumes after adjusting for ICV. We found no age-gender interactions.

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“…Flood and Coleman 1988;Gur et al 1991). However, later reports showed that the cognitive decline in elderly is not unequivocally associated with singular changes like shrinkage of the brain volume (Van Petten 2004;Van Petten et al 2004), white matter atrophy (Bartzokis 2004), neuron loss (Morrison and Hof 1997) or synapse loss (Masliah et al 2006), as originally assumed. Multiple sources or their interaction are better suited to explain the cognitive decline in aging.…”

Section: Neuronal Plasticity and Compensation In Agingmentioning

confidence: 95%

Neurocognition of aging in working environments

Gajewski

Falkenstein

2011

ZAF

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Aging is accompanied by changes in sensory, motor and cognitive functions. Particularly, a high status of socalled fluid cognitive functions is crucial for the employability at an older age. This status, which can be assessed by psychometric and neuroimaging methods, depends on a number of factors like physical constitution, nutrition, education and work demands. This paper systematically analyses factors affecting cognitive functions in aging and reviews current neuroscientific findings regarding training induced neuronal plasticity and compensation of cognitive declines in aging. In the second part the relationship between cognitive functions and the type of work will be discussed and the project PFIFF presented as an example for transfer of neuroscientific basic research to an applied context that aimed at ameliorating and evaluating age-and job-related cognitive deficits. The results of the first project period showed that cognitive decline, as revealed in behavior and brain wave data, may be accelerated by long-lasting unchallenging work and, hence, may occur already in middle age. In the second part of PFIFF a 3-month program consisting of a supervised cognitive training was implemented in a group of 120 assembly-line employees. Before and after the training

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Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities

Cited by 194 publications

References 90 publications

Cortical thickness is linked to executive functioning in adulthood and aging

Cortical thickness is linked to executive functioning in adulthood and aging

Aging, gender, and the elderly adult brain: An examination of analytical strategies

Neurocognition of aging in working environments

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