Memory amelioration by hesperidin conjugated gold nanoparticles in diabetes induced cognitive impaired rats

Pradhan, Sweta Priyadarshini; Sahoo, Shraban Kumar; Behera, Anindita; Sahoo, Rajesh Kumar; Sahu, Pratap Kumar

doi:10.1016/j.jddst.2022.103145

Cited by 14 publications

(6 citation statements)

References 48 publications

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“…The memory test performed with behavioural evaluation in the treated rats indicated good memory retention in Y-maze, elevated plus maze and radial arm maze. Histopathological studies on brain tissue affirm the neuroprotective effect of HSP AuNPs (Pradhan et al, 2022). Additionally, research has shown that the HSP nanoparticle can reduce AD-related anxiety by enhancing the brain's antioxidant (Hajizadeh Moghaddam et al, 2020).…”

Section: Hesperidinmentioning

confidence: 79%

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Chellammal¹,

Singh²,

Kumar³

et al. 2022

J. Phytonanotech. Pharmaceut. Sci.

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Alzheimer's disease, (AD) is a neurodegenerative disease characterized by cognitive dysfunction and is an age-related disease. The neuropathology of AD is -amyloid (A) peptide in the brain and causes neurofibrillary tangles. The acetylcholine level is reduced in the hippocampus and acetylcholinesterase (AChE) is enhanced causing memory deterioration. Oxidative damage is one of the major cellular impacts affected during AD condition. Plant derived polyphenols are the compounds which are having remarkable effect of free radical scavenging effect and AChE inhibitory effect in brain. The treatment with phytocompounds were highly effective for neuroprotection and systematically regulates the brain organic balance. The limitations of phytocompounds to penetrate the blood brain barrier is majorly surpassed by the novel drug delivery systems such as nanoparticles. Nanoformulations of phytocompounds have a greatest potential for the target delivery of drugs to the brain and have maximal therapeutic effect. This review states the remarkable impacts of selected phytonanoparticles for the treatment of AD.

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Section: Hesperidinmentioning

confidence: 79%

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Chellammal¹,

Singh²,

Kumar³

et al. 2022

J. Phytonanotech. Pharmaceut. Sci.

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“…Hence, it is also one of the methods for assessing spatial working memory [40]. The experimental data of the EPM test, e.g., a reduction in TL on the second trial, reflected the learning capacity of animals and also revealed the ability to retain memory [41]. Additionally, lycopene, a carotenoid compound, improved the β-Amyloid 1-42 peptide-induced AD and resulted in an improvement of TL in the EPM test in rats [21,42].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Processes of Beta-Carotene in Streptozotocin-Induced Diabetic Vascular Dementia in Rats

Lim

Muthuraman

2022

Processes

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Beta-carotene (BC) is a precursor of vitamin A and an excellent antioxidant. It protects the vascular system. Vascular dementia (VaD) is one of the aging disorders causing memory dysfunction. The available medicines for the management of VaD are limited. The present study aimed to evaluate the ameliorative effect of BC in streptozotocin (STZ)-induced diabetic VaD in rats. Diabetic VaD was induced through the administration of nicotinamide (NA, 50 mg/kg; i.p.) and STZ (50 mg/kg; i.p.). The test compound BC (50 and 100 mg/kg; p.o.) and reference compound donepezil (1 mg/kg; p.o.) were administered for 15 consecutive days. Cognitive changes were assessed by transfer latency (TL) using the elevated plus maze (EPM) test. The changes in acetylcholinesterase (AChE) activity were estimated in the septohippocampal system of rat brains. The administration of STZ caused significant changes in cognitive functions (increased TL) as compared to the normal group. BC ameliorated the anxiety-related cognitive behavior and neurotransmitter (elevated AChE) changes provoked by diabetic VaD. Therefore, BC could be a potential therapeutic candidate in the management of VaD.

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“…The major mechanism of neurotoxicity is also associated with oxidative stress. Hence, some reports reported that using antioxidants along with metal nanoparticles reduced neurotoxicity by reducing ROS [20]. Selenium, gold, ruthenium, and zinc oxide nanoparticles are reported to be safer and more effective in treating AD [90,139].…”

Section: Biocompatibility Of Metal Nanoparticles For the Treatment Of Admentioning

confidence: 99%

“…Oxidative stress is one of the target mechanisms in the treatment of AD. The high permeability and biocompatibility of metal nanoparticles like gold, selenium, and ruthenium exhibit an antioxidant activity that facilitates the cognition deficit in the early stages of AD [19,20]. But some transition metal oxide nanoparticles like iron oxide, copper oxide, cobalt oxide, and titanium dioxide generate ROS in vivo.…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticles in Alzheimer’s Disease

Behera

Pradhan

et al. 2023

ADR

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Nanotechnology has emerged in different fields of biomedical application, including lifestyle diseases like diabetes, hypertension, and chronic kidney disease, neurodegenerative diseases like Alzheimer’s disease (AD), Parkinson’s disease, and different types of cancers. Metal nanoparticles are one of the most used drug delivery systems due to the benefits of their enhanced physicochemical properties as compared to bulk metals. Neurodegenerative diseases are the second most cause affecting mortality worldwide after cancer. Hence, they require the most specific and targeted drug delivery systems for maximum therapeutic benefits. Metal nanoparticles are the preferred drug delivery system, possessing greater blood-brain barrier permeability, biocompatibility, and enhanced bioavailability. But some metal nanoparticles exhibit neurotoxic activity owing to their shape, size, surface charge, or surface modification. This review article has discussed the pathophysiology of AD. The neuroprotective mechanism of gold, silver, selenium, ruthenium, cerium oxide, zinc oxide, and iron oxide nanoparticles are discussed. Again, the neurotoxic mechanisms of gold, iron oxide, titanium dioxide, and cobalt oxide are also included. The neuroprotective and neurotoxic effects of nanoparticles targeted for treating AD are discussed elaborately. The review also focusses on the biocompatibility of metal nanoparticles for targeting the brain in treating AD. The clinical trials and the requirement to develop new drug delivery systems are critically analyzed. This review can show a path for the researchers involved in the brain-targeted drug delivery for AD.

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Memory amelioration by hesperidin conjugated gold nanoparticles in diabetes induced cognitive impaired rats

Cited by 14 publications

References 48 publications

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Ameliorative Processes of Beta-Carotene in Streptozotocin-Induced Diabetic Vascular Dementia in Rats

Metal Nanoparticles in Alzheimer’s Disease

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