Mémoire épique et Génie du lieu, études réunies par Caroline Cazanave

Timelli, Maria Colombo

doi:10.4000/studifrancesi.16146

studifrancesi

2019

DOI: 10.4000/studifrancesi.16146

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Mémoire épique et Génie du lieu, études réunies par Caroline Cazanave

Maria Colombo Timelli¹

Abstract: Mémoire épique et Génie du lieu, études réunies par Caroline CAZANAVE, Lille, Centre d'études médiévales et dialectales de Lille 3, «Bien Dire et Bien Aprandre», hors-série 2, 2017, 379 pp.

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2024

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“…Mice were challenged intranasally with 1.0 × 10 7 C. neoformans cells per animal (KN99-or H99)48 14 days after last immunization. The animals were observed daily for 30 days and euthanized if showing more than 20% weight loss or inability to feed.…”

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confidence: 99%

Semi-synthetic glycoconjugate vaccine candidate againstCryptococcus neoformans

Crawford,

Liporagi-Lopes,

Coelho

et al. 2024

Preprint

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Cryptococcus neoformans is a fungus classified by the World Health Organization as a critically important pathogen, posing a significant threat to immunocompromised individuals. In this study, we present the chemical synthesis and evaluation of two semi-synthetic vaccine candidates targeting the capsular polysaccharide glucuronoxylomannan (GXM) of C. neoformans. These semi-synthetic glycoconjugate vaccines contain the identical synthetic decasaccharide (M2 motif) antigen. This motif is present in serotype A strains, which constitute 95% of clinical cryptococcosis cases. This synthetic oligosaccharide was conjugated to two proteins (CRM197 and Anthrax 63 kDa PA) and tested for immunogenicity in mice. The conjugates elicited a specific antibody response that bound to the M2 motif but also exhibited additional cross-reactivity towards M1 and M4 GXM motifs. Both glycoconjugates produced antibodies that bound to GXM in ELISA assays and to live fungal cells. Mice immunized with the CRM197 glycoconjugate produced opsonic antibodies and displayed trends toward increased median survival relative to mice given a mock PBS injection (18 vs 15 days, p = 0.06). While these findings indicate promise, achieving a successful vaccine demands further optimization of the glycoconjugate. It could serve as a component in a multi-valent GXM motif vaccine, enhancing both strength and breadth of immune responses.

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mentioning

confidence: 99%

Semi-synthetic glycoconjugate vaccine candidate againstCryptococcus neoformans

Crawford,

Liporagi-Lopes,

Coelho

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Mémoire épique et Génie du lieu, études réunies par Caroline Cazanave

Abstract: Mémoire épique et Génie du lieu, études réunies par Caroline CAZANAVE, Lille, Centre d'études médiévales et dialectales de Lille 3, «Bien Dire et Bien Aprandre», hors-série 2, 2017, 379 pp.

Cited by 1 publication

References 0 publications

Semi-synthetic glycoconjugate vaccine candidate againstCryptococcus neoformans

Semi-synthetic glycoconjugate vaccine candidate againstCryptococcus neoformans

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