Membranoproliferative glomerulonephritis and plexogenic pulmonary arteriopathy in a homosexual man with acquired immunodeficiency syndrome

Kim, Kenneth K.; Factor, Stephen M.

doi:10.1016/s0046-8177(87)80417-3

Cited by 125 publications

(42 citation statements)

References 6 publications

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“…For HIV-related pulmonary hypertension, the first clinical report of an association between infection and the development of lesions appeared in 1987 [84], followed by other reports [85][86][87] but with no evidence for the presence of the virus in PH vascular lesions. As PH is frequently diagnosed when it is advanced, the incidence of PH in HIV-infected patients is likely underestimated, although a recent report demonstrates a high prevalence of PH in HIV-infected children [88].…”

Section: Pathobiologymentioning

confidence: 99%

Pathology of Pulmonary Hypertension

Tuder

Marecki

Richter

et al. 2013

Clinics in Chest Medicine

217

107

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Section: Pathobiologymentioning

confidence: 99%

Pathology of Pulmonary Hypertension

Tuder

Marecki

Richter

et al. 2013

Clinics in Chest Medicine

217

107

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“…5 AIDS-related PH also carries the same poor prognosis as idiopathic PH: one study found that PH was the final cause of death in 72% of the patients diagnosed with the condition, and 3-year postdiagnosis survival rates ranged from 28 to 47%, depending on the condition of the patients at presentation. 6 Although there have been a variety of theories put forward, including cytokine imbalance, alteration of adrenergic tone, and concurrent autoimmune disease, 7 the cause of AIDS-related PH is not clear.…”

mentioning

confidence: 99%

Pulmonary Hypertension Can Be a Sequela of Prior Pneumocystis Pneumonia

Swain

Han

Harmsen

et al. 2007

The American Journal of Pathology

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Improved treatment regimens have reduced fatalities from opportunistic diseases, such as Pneumocystis pneumonia, in AIDS patients. However, serious chronic conditions, including pulmonary hypertension (PH), are increasing in this group. We report here that when CD4 T cells in Pneumocystis-infected mice are temporally depleted and then allowed to return, the extended inflammation results in PH that persists after Pneumocystis is eliminated. Using this model of PH, we have found that i) the onset of PH is correlated with the return of CD4 T cells, but PH persists after CD4 levels diminish; ii) vascular remodeling accompanies PH, but whereas temporary medial hypertrophy is evident with transient PH in immunocompetent mice, persistent PH is associated with perivascular fibrosis; iii) elevated levels of the fibrotic mediator FIZZ1 are found in bronchoalveolar lavage fluid of mice with persistent PH; and iv) although Th2-related mechanisms may be involved in PH etiology, PH still occurs in interleukin-4 receptordeficient mice under these conditions. Overall, the data presented here demonstrate that the immune response to an infectious disease pathogen, such as Pneumocystis, can, when perturbed and prolonged, lead to later development of a serious chronic condition such as PH.

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“…O primeiro caso de HAP associado ao HIV foi descrito em 1987 por Kim e Factor em um paciente hemofílico que também apresentava glomerulonefrite membranoproliferativa 16 . Posteriormente, diversos casos têm sido descritos em pacientes sem outro fator além da infecção pelo HIV para explicar a presença de hipertensão pulmonar 11 .…”

Section: Discussionunclassified

Hipertensão pulmonar associada à síndrome da imunodeficiência adquirida: apresentação de cinco casos e revisão da literatura

Mendes

Roncal

Costa

et al. 2009

Rev. Soc. Bras. Med. Trop.

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Alterações cardiovasculares relacionadas à síndrome de imunodeficiência adquirida (SIDA) são bem conhecidas, e incluem pericardite, miocardite e miocardiopatia dilatada. Atualmente com o aumento da sobrevida dos pacientes decorrente do tratamento antiretroviral (TARV) e profilaxia otimizada das infecções oportunistas, condições não infecciosas têm sido reconhecidas, entre elas a hipertensão arterial pulmonar (HAP). A hipertensão arterial pulmonar é uma doença grave da circulação pulmonar, caracterizada por alterações na parede vascular localizadas inicialmente nos segmentos pré-capilares da circulação pulmonar RESUMODiversas doenças cardiorespiratórias podem complicar a síndrome da imunodeficiência adquirida. A hipertensão pulmonar é uma rara doença com um pobre prognóstico. Nós descrevemos esta síndrome em cinco pacientes com infecção pelo vírus da imunodeficiência adquirida em nosso serviço com revisão da literatura. Palavras-chaves:Hipertensão pulmonar. Síndrome da imunodeficiência adquirida. Insuficiência cardíaca. ABSTRACTSeveral cardiorespiratory diseases may complicate the acquired immunodeficiency syndrome. Pulmonary hypertension is a rare clinical disorder with a poor prognosis. We describe this syndrome in five patients seen at our service who presented infection with the acquired immunodeficiency virus, and we review the literature.Key-words: Pulmonary hypertension. Acquired immunodeficiency syndrome. Heart failure.e que evoluem com remodelação, vasoconstrição e trombose in situ. 31 Evolui com aumento progressivo da resistência vascular pulmonar, falência ventricular direita e morte quando não tratada. A incidência de HAP associada ao vírus da imunodeficiência adquirida (HIV) é 0,5%, e na população geral em torno de 0,02% 15. Em estudo multicêntrico e prospectivo na era da TARV, a prevalência de HAP foi de 0,46% 33. Descrevemos as características clínicas, hemodinâmicas e evolução de cinco pacientes com HAP associadas ao HIV acompanhados na Divisão de Doenças

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Membranoproliferative glomerulonephritis and plexogenic pulmonary arteriopathy in a homosexual man with acquired immunodeficiency syndrome

Cited by 125 publications

References 6 publications

Pathology of Pulmonary Hypertension

Pathology of Pulmonary Hypertension

Pulmonary Hypertension Can Be a Sequela of Prior Pneumocystis Pneumonia

Hipertensão pulmonar associada à síndrome da imunodeficiência adquirida: apresentação de cinco casos e revisão da literatura

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