Membranoproliferative Glomerulonephritis and Persistent Hypocomplementaemia

Cameron, J S; Glasgow, Eric; Ogg, C S; White, Richard

doi:10.1136/bmj.4.5726.7

Cited by 110 publications

(52 citation statements)

References 47 publications

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“…3) . Our results are in agreement with those of other authors who have reported similar survival rates with smaller numbers of cases [1-3, 5-10, 12, 13, 16], mostly including many children as well as cases with MPGN type II [1][2][3][5][6][7][8][9]12]. Only Barbiano di Belgiojoso et al [4] got more favorable results with a 70% probability of maintaining renal function after 10 years.…”

Section: Discussionsupporting

confidence: 83%

“…We are not able to provide an explanation for this discrepancy with the studies of other authors who have found the nephrotic syndrome to be associated with a less favorable prognosis. In previous investigations no corre lation could be seen between the frequency and the severity of hypocomplementemia on one hand and the progression/remission of MPGN on the other [1,[4][5][6]10,12,13,16]. In a study of 40 patients Swainson et al [2], however, found a lowersurvival rate in hypocomplementemicas opposed to normocomplementemic MPGN.…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Long-Term Prognosis of Membranoproliferative Glomerulonephritis Type I

Schmitt

Böhle

Reineke³

et al. 1990

Nephron

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A b stra c t. We carried out a retrospective investigation in 220 patients to assess the influence of various parameters on the long-term course of membranoproliferative glomerulonephritis (MPGN) type 1.50 patients (23%) died during the follow-up period of 59 months on average, in another 57 (26%) end-stage renal failure developed. 54 patients (24%) suffered from chronic renal failure, stable renal function (creatinine below 1.3 mg/dl) was preserved in 59 patients (27%).5 years after biopsy 49% of the patients had already died or needed regular dialysis treatment; after 10 years this proportion increased to 64%. Morphological findings: The outcome was with the exception of focal crescent formations -not determined by the severity of glomerular changes ; the survival rate, however, decreased significantly, if tubulointerstitial lesions were present as defined by acute renal failure, interstitial fibrosis ora combination of both. Clinical parameters; A progressive deterioration of renal function and an increasing number of renal deaths was noticed, when elevated serum creatinine levels at the time of biopsy and high blood pressure values during the follow-up period were observed. 26 patients died from hypertension, 18 of whom before reaching end-stage renal failure. Nephrotic syndrome and the degree of proteinuria as well as antiphlogistic and immunosuppressive treatment did not influence the prognosis of MPGN type 1.Studies on the long-term course of membranoprolifer ative glomerulonephritis (MPGN) have previously been carried out only on small numbers of cases, due to the rarity of the disease [1 13]. The prognosis is generally considered unfavorable [1-16], but there is still uncer tainty about the factors causing the progression to endstage renal failure or even death of the patient. In earlier investigations [14,[17][18][19] we noticed certain correlations between the severity of tubulointerstitial changes at the time of biopsy and renal function in MPGN. Therefore we were interested in determining whether, and to what extent, these changes as well as the clinical parameters blood pressure (BP), creatinine, proteinuria and hematu ria are of prognostic significance.1 Supported by the Deutsche Forschungsgemeinschaft (DFG). Material and MethodsAmong 36000 patients in our renal biopsy registry we found 346 in whom idiopathic MPGN was diagnosed between 1965 and 1984. By further investigations (immunohistology, electron microscopy) 108 patients had to be excluded from our study because primary diagnosis was not correct. They either suffered from other renal disorders (endocapillary/mesangioproliferative/membranous glo merulonephritis) or renal involvement due to underlying diseases such as lupus erythematodes, cryoglobulinemia and monoclonal gammopathy/multiple myeloma: 18 patients with MPGN type II (dense deposits) were also excluded. In the remaining 220 cases (male:female ratio = 1.75:l: mean age 36.4± 15.5 years) the lightmicroscopic diagnosis of MPGN was confirmed and type I (subendothelial deposits) could be ...

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 92%

Long-Term Prognosis of Membranoproliferative Glomerulonephritis Type I

Schmitt

Böhle

Reineke³

et al. 1990

Nephron

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show abstract

“…is a form of chronic nephritis which has a distinctive glomerular morphology and is frequently accompanied by hypocomplementemia (1)(2)(3). The serum of most of the hypocomplementemic patients contains an abnormal anticomplementary substance which is capable of breaking down the third component of complement, C3, when the serum is added to normal human serum ( NHS)…”

Section: Introduction Membranoproliferative Glomerulonephritis (Mpgn)mentioning

confidence: 99%

Hypocomplementemia of Membranoproliferative Nephritis DEPENDENCE OF THE NEPHRITIC FACTOR REACTION ON PROPERDIN FACTOR B

Ruley¹,

Forristal²,

Davis³

et al. 1973

J. Clin. Invest.

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“…In AGN post streptococcus the depression of C3 occurs in 2 to 8 weeks, while in MPGN C3 is low for months or years (Cameron et al, 1970). …”

Section: Resultsmentioning

confidence: 99%

“…To know which kind of complement activation is operating in our patients, 3. To look for the possibility of using this examination as a diagnostic aid in the differential diagnosis in certain kinds of glomerular disorders.…”

Section: Introductionmentioning

confidence: 99%