Membranes, technologies and long‐term results in chronic haemodialysis

Stefoni, Sergio; Scolari, Maria; Cianciolo, Giuseppe; Mosconi, Giovanni; Sanctis, L. B. De; Pascalis, Antonio De; Donati, Gabriele; Manna, Cristian; Sestigiani, Elena; Grammatico, F.

doi:10.1093/ndt/15.suppl_1.12

Cited by 3 publications

(4 citation statements)

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“…If the number of samples is quite small, it tends to have a greater impact on the observed results. It has been reported that the incidence of hypertension was as high as 50-90% in hemodialysis patients, whereas the incidence of cardiovascular disease was 30-50% [6, 8]. In our study, the incidence of hypertension in hemodialysis patients was 73.6%, and the incidence of cardiovascular disease was 25%.…”

Section: Discussionsupporting

confidence: 47%

“…However, the etiology and underlying mechanism are not entirely clear. It may be related to renal dysfunction, dialysis adequacy, the type of dialysis membrane and uremia basic diseases, genetic and other factors [6-9]. Apolipoprotein E (ApoE) is an important component of very low-density lipoprotein (VLDL), high-density lipoprotein (HDL) and chylomicrons, which may play an important role in lipid metabolism [10-12].…”

Section: Introductionmentioning

confidence: 99%

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Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Wang¹,

Wang

et al. 2017

J Clin Med Res

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BackgroundThe aim was to investigate the clinical characteristics of lipid metabolism and the effect of apolipoprotein E (ApoE) gene polymorphism on lipid metabolism in hemodialysis patients.MethodsThe serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), ApoA1, ApoB, ApoE and lipoprotein Lp(a) were detected by polymerase chain reaction-restriction fragment length (PCR-RFLP).ResultsThe level of serum TG was significantly increased and the level of HDLC was significantly decreased in hemodialysis patients. Serum TG level was 33% higher than normal, and HDLC was 10.4% less than normal. The correlation analysis showed that TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. The incidence of hypertension in hemodialysis patients was 73.6% and cardiovascular disease was 25%. The level of TG in the cardiovascular disease group was significantly higher than that in the non-cardiovascular disease group, and there was no significant difference between the hypertensive group and the non-hypertensive group. ApoE gene polymorphism test showed that the frequency of ApoE genotype ε3/3 and allele ε3 was the highest in hemodialysis patients, and the levels of TC, TG and LDLC were higher in ApoE genotype ε3/4 + ε4/4.ConclusionThe levels of serum TG and ApoB were significantly increased in patients with hemodialysis, and HDLC and other indexes were significantly decreased. The level of TG in patients with cardiovascular complications was significantly higher than in patients without complications. TG level was significantly correlated with serum albumin level and extracorporeal circulation blood flow during dialysis. HDLC was significantly correlated with KT/V. Hemodialysis patients who had ApoE allele ε4 are prone to lipid metabolism disorders.

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Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Wang¹,

Wang

et al. 2017

J Clin Med Res

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“…I pored značajnog naučno-tehnološkog napretka u lečenju dijalizom koji je ostvaren tokom poslednjih nekoliko decenija, kod ovih bolesnika održava se još uvek visoka stopa morbiditeta i mortaliteta. U osnovi ovog problema su akutne i hronične komplikacije primene ove procedure, u čijem nastanku delom učestvuje i sam tretman dijalizom (1). Od pre nekoliko godina u kliničku praksu su uvedene nove metode ekstrakorporalne depuracije krvi, kao što su on-line Страна 726…”

Section: Uvodunclassified

“…Ispitivanjem je obuhvaćeno ukupno 55 bolesnika (23 muškarca i 22 žene), prosečne životne dobi 51 ± 14,0 (16-78) godina. Prosečna dužina lečenja hemodijalizom je bila 5 ± 4,23 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) godina.…”

Section: Rezultatiunclassified

Comparative analysis of the efficacy and biocompatibility of various methods of dialysis

Zivanović

Hrvacević²,

Kovačević

et al. 2005

VOJNOSANIT PREGL

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Postdilution on-line hemodiafiltration in comparison with standard hemodialysis provided the more effective elimination of small and middle uremic toxins molecules and a significantly higher degree of biocompatibility. The patients treated with standard hemodialysis frequently do not achieve the minimal value of urea Kt/V index prescribed by National Kidney Foundation-Dialysis Outcomes Quality Inatiatives standards. These patients also have significantly higher serum CRP values which suggest the state of chronic microinflammation.

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Non-infectious complications of peritoneal dialysis and hemodialysis

Harvey¹

2004

Pediatric Dialysis

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Membranes, technologies and long‐term results in chronic haemodialysis

Cited by 3 publications

References 1 publication

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Detection of Apolipoprotein E Gene Polymorphism and Blood Lipid Level in Hemodialysis Patients

Comparative analysis of the efficacy and biocompatibility of various methods of dialysis

Non-infectious complications of peritoneal dialysis and hemodialysis

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