Membranes for oxygenators and plasma filters

Breiter, Stefan

doi:10.1533/9780857090843.1.3

Cited by 4 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this section, we wanted to characterize the performance of the PMP membranes. According to Table 1 , the hollow fiber (HF) geometry was commonly adopted for ECMO systems [ 22 , 24 ]. Besides, the PMP piece membranes prepared in Section 3.3 were a little small and hard to obtain stable performance data.…”

Section: Resultsmentioning

confidence: 99%

“…According to these studies, it can be known that a suitable diluent was the most decisive factor for controlling the structure of the PMP membranes via the TIPS process. This is because that as the core materials to realize the gas exchange in the ECMO systems, the PMP membranes should be hydrophobic, and possess structures that consist of a uniform and bicontinuous porous cross-section, and a thin dense surface layer to ensur a high gas permeability and satisfy blood rejection [ 23 , 24 ]. Commonly, as the interaction between the polymer and the diluents is comparatively good, a solid-liquid (S-L) phase separation happens, resulting in crystalline structures with lower porosity, while as the interaction between the polymer and the diluents is comparatively weak, a liquid-liquid (L-L) phase separation may occur, resulting in a bicontinuous or cellular structure with a higher porosity [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Novel Green Diluent for the Preparation of Poly(4-methyl-1-pentene) Membranes via a Thermally-Induced Phase Separation Method

Tang

Lin

et al. 2021

Membranes

View full text Add to dashboard Cite

The use of green solvents satisfies safer chemical engineering practices and environmental security. Herein, myristic acid (MA)—a green diluent—was selected to prepare poly- (4-methyl-1-pentene) (PMP) membranes with bicontinuous porous structure via a thermally induced phase separation (TIPS) process to maintain a high gas permeability. Firstly, based on the Hansen solubility parameter ‘distance’, Ra, the effect of four natural fatty acids on the PMP membrane structure was compared and studied to determine the optimal green diluent, MA. The thermodynamic phase diagram of the PMP-MA system was calculated and presented to show that a liquid-liquid phase separation region could be found during the TIPS process and the monotectic point was around 34.89 wt%. Then, the effect of the PMP concentration on the morphologies and crystallization behavior was systematically investigated to determine a proper PMP concentration for the membrane preparation. Finally, PMP hollow fiber (HF) membranes were fabricated with a PMP concentration of 30 wt% for the membrane performance characterization. The resultant PMP HF membranes possessed good performances that the porosity was 70%, the tensile strength was 96 cN, and the nitrogen flux was 8.20 ± 0.10 mL·(bar·cm2·min)−1. We believe that this work can be a beneficial reference for people interested in the preparation of PMP membranes for medical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Green Diluent for the Preparation of Poly(4-methyl-1-pentene) Membranes via a Thermally-Induced Phase Separation Method

Tang

Lin

et al. 2021

Membranes

View full text Add to dashboard Cite

show abstract

“…While the higher gas flow rates increase operating pressure and the accompanying high risk of microbubble formation, an improvement in gas transfer efficiency is also possible 35,36 . An arterial filter was included in the oxygenator circuit to reduce thrombus formation, ingress of artificial particles, including gaseous emboli 37 . However, this approach results in increased blood‐side pressure and cumbersome circuits, making it unsuitable for pediatric and neonatal applications.…”

Section: Resultsmentioning

confidence: 99%

“…35,36 An arterial filter was included in the oxygenator circuit to reduce thrombus formation, ingress of artificial particles, including gaseous emboli. 37 However, this approach results in increased blood-side pressure and cumbersome circuits, making it unsuitable for pediatric and neonatal applications. For such special cardiopulmonary circuits, PSF membranes similar to the E-01 fibers presented in this study may be preferred.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Teber,

Altinay,

Naziri Mehrabani

et al. 2024

J of Applied Polymer Sci

View full text Add to dashboard Cite

Blood oxygenators are used to saturate oxygen levels and remove carbon dioxide from the body during cardiopulmonary bypass. Although the natural lung is hydrophilic, commercially used oxygenator materials are hydrophobic. Surface hydrophobicity weakens blood compatibility, as long‐term contact with the blood environment may lead to different degrees of blood activity. Polysulfone may be considered an alternative hydrophilic material in the design of oxygenators. Therefore, it may be directed toward developing hydrophilic membranes. This study aims to investigate the feasibility of achieving blood gas transfer with a polysulfone‐based microporous hollow fiber membrane and compare it with the commercially available polypropylene membranes. Structural differences in the membrane morphology, surface hydrophilicity, tortuosity, mass transfer rate, and material properties under different operation conditions of temperature and flow rates are reported. The polysulfone membrane has a water contact angle of 81.3°, whereas a commercial polypropylene membrane is 94.5°. The mass transfer resistances (s/m) for the polysulfone and polypropylene membranes are calculated to be 4.8 × 104 and 1.5 × 104 at 25°C, respectively. The module made of polysulfone was placed in the cardiopulmonary bypass circuit in parallel with the commercial oxygenator, and pH, pO2, pCO2 levels, and metabolic activity were measured in blood samples.

show abstract

“…Firstly, due to the use of additive technology, a microfiltration membrane made of PMP can be built directly into the device case. Secondly, PMP is characterized by high hemocompatibility, e.g., this material is widely used to produce hollow fiber for blood oxygenators [25][26][27]. To use a blend based on this polymer to form a membrane precursor, a suitable second polymer is needed that can then be easily extracted.…”

Section: Introductionmentioning

confidence: 99%

Formation of Microfiltration Membranes from PMP/PIB Blends: Effect of PIB Molecular Weight on Membrane Properties

et al. 2020

View full text Add to dashboard Cite

A series of microfiltration membranes were fabricated by the extraction of polyisobutylene (PIB) from its immiscible blends with polymethylpentene (PMP). Three PIB with different molecular weight of 7.5 × 104 (Oppanol B15), 34 × 104 (Oppanol B50) and 110 × 104 (Oppanol B100) g/mol, respectively, were used to evaluate the effect of molecular weight on the porous structure and transport properties of resulting PMP-based membranes. To mimic the conditions of 3D printing, the flat-sheet membranes were fabricated by means of melting of mixtures of various PMP and PIB concentrations through the hot rolls at 240 ∘ C followed by a quick cooling. The rheology study of individual components and blends at 240 ∘ C revealed that PIB B50 possessed the most close flow curve to the pure PMP, and their blends demonstrated the lowest viscosity comparing to the compositions made of PIB with other molecular weights (B15 or B100). SEM images of the cross-section PMP membranes after PIB extraction (PMP/PIB = 55/45) showed that the use of PIB B50 allowed obtaining the sponge-like porous structure, whereas the slit-shaped pores were found in the case of PIB B15 and PIB B100. Additionally, PMP/B50 blends demonstrated the optimum combinations of mechanical properties (str = 9.1 MPa, E = 0.20 GPa), adhesion to steel (adh = 0.8 kPa) and retention performance (R240 nm = 99%, R38 nm = 39%). The resulting membranes were non- or low-permeable for water if the concentration of PIB B50 in the initial blends was 40 wt.% or lower. The optimal filtration performance was observed in the case of PMP/B50 blends with a ratio of 55/45 (Pwater = 1.9 kg/m2hbar, R240 nm = 99%, R38 nm = 39%) and 50/50 (Pwater = 1100 kg/m2hbar, R240 nm = 91%, R38 nm = 36%).

show abstract

Membranes for oxygenators and plasma filters

Cited by 4 publications

References 20 publications

A Novel Green Diluent for the Preparation of Poly(4-methyl-1-pentene) Membranes via a Thermally-Induced Phase Separation Method

A Novel Green Diluent for the Preparation of Poly(4-methyl-1-pentene) Membranes via a Thermally-Induced Phase Separation Method

Characterization and comparative evaluation of polysulfone and polypropylene hollow fiber membranes for blood oxygenators

Formation of Microfiltration Membranes from PMP/PIB Blends: Effect of PIB Molecular Weight on Membrane Properties

Contact Info

Product

Resources

About