Membrane-tethered activation design of a photosensitizer boosts systemic antitumor immunity<i>via</i>pyroptosis

Lu, Pei; Liu, Xianjun; Chu, Xia; Wang, Fenglin; Jiang, Jian‐Hui

doi:10.1039/d2sc07044h

Cited by 13 publications

(8 citation statements)

References 33 publications

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“…Employing the enzyme overexpressed on cell surface, Wang's group designed an enzyme-activated PS (aPYCl4), endowing the phenylbenzopyrylium core with bi-pendant zwitterionic lipid anchors to enhance membrane retention. [15] In vitro and live cell analysis demonstrated its superior membrane-localized ability to produce 1 O 2 under NIR light irradiation and specific phototoxicity to tumor cells in the presence of aminopeptidase-N. Intriguingly, this PS can ablate primary tumors and suppress distant tumors by triggering immunotherapy, offering a promising design for combined cancer photoimmunotherapy. Inspired by viscosity-sensitive probes, Zhou et al developed a dicyano-substituted molecule, CQ-IC, with inhibited twisted internal charge transfer effect in high-viscosity environments.…”

Section: Small Molecular Psmentioning

confidence: 99%

Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Wu,

Hu,

Yoon

2024

Angewandte Chemie

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The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction and information exchange. Therefore, disrupting its structure or impairing its functions can potentially cause irreversible cell damage. Presently, the tumor cell membrane is recognized as a promising therapeutic target for various treatment methods. Given the extensive research focused on cell membranes, it is both necessary and timely to discuss these developments, from materials design to specific biomedical applications. This review covers treatments based on functional materials targeting the cell membrane, ranging from well‐known membrane‐anchoring photodynamic therapy to recent lysosome‐targeting chimaeras for protein degradation. The diverse therapeutic mechanisms are introduced in the following sections: membrane‐anchoring phototherapy, self‐assembly on the membrane, in situ biosynthesis on the membrane, and degradation of cell membrane proteins by chimeras. In each section, we outline the conceptual design or general structure derived from numerous studies, emphasizing representative examples to understand advancements and draw inspiration. Finally, we discuss some challenges and future directions in membrane‐targeted therapy from our perspective. This review aims to engage multidisciplinary readers and encourage researchers in related fields to advance the fundamental theories and practical applications of membrane‐targeting therapeutic agents.

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Section: Small Molecular Psmentioning

confidence: 99%

Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Wu,

Hu,

Yoon

2024

Angewandte Chemie

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“…[104,105] Recently, it has been shown that ROS produced from PDT plays a crucial role in inducing pyroptosis. [106,107] The development of triggered pyroptosis PSs based on nanoscience offers new opportunities for modulated pyroptosis-based nanomaterials for cancer therapy, with many advantages such as high specificity, low drug resistance, and reduced side effects. [108][109][110] This emerging research focus on PSs modulated pyroptosis pathway holds the potential for improving the efficacy and safety of cancer treatment.…”

Section: Nanomaterials Based Photodynamic Therapy Triggered Pyroptosismentioning

confidence: 99%

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

Wang

2023

Adv Healthcare Materials

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Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to characteristic outcomes including cell swelling, membrane perforation, and release of cell contents. Research underscores the role of pyroptosis in the etiology and progression of many diseases, making it a focus of research intervention as scientists explore ways to regulate pyroptosis pathways in disease management. Despite numerous reviews detailing the relationship between pyroptosis and disease mechanisms, few delve into recent advancements in nanomaterials as a mechanism for modulating the pyroptosis pathway to mitigate disease effects. Therefore, there is an urgent need to fill this gap and elucidate the path for the use of this promising technology in the field of disease treatment. This review article delves into recent developments in nanomaterials for disease management through pyroptosis modulation, details the mechanisms by which drugs interact with pyroptosis pathways, and highlights the promise that nanomaterial research holds in driving forward disease treatment.

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“…2,3 It has been confirmed recently that ROS can induce pyroptosis. [4][5][6] However, there are few works that can accurately induce pyroptosis by distinguishing normal cells and cancer cells through fluorescence (FL) imaging guidance. 7 Moreover, PDT-mediated pyroptosis usually does not damage DNA in the nucleus, which leaves the risk of cancer recurrence.…”

Section: Introductionmentioning

confidence: 99%

An esterase-activated diketopyrrolopyrrole-based theranostic prodrug for precise pyroptosis and synergistic chemo-photodynamic therapy of pancreatic cancer

Gu,

Yang,

et al. 2024

Mater. Chem. Front.

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Membrane-tethered activation design of a photosensitizer boosts systemic antitumor immunityviapyroptosis

Abstract: Pyroptotic immunogenic cell death presents an emerging targeting pathway for cancer immunotherapy. We report a novel membrane-tethered activation design of photosensitizer (PS) that boosts systemic anti-tumor immunity to primary and...

Cited by 13 publications

References 33 publications

Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications

Nanomaterials for Disease Treatment by Modulating the Pyroptosis Pathway

An esterase-activated diketopyrrolopyrrole-based theranostic prodrug for precise pyroptosis and synergistic chemo-photodynamic therapy of pancreatic cancer

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