Membrane permeability is unnecessary for guided generation of new bone. An experimental study in the rabbit.

Abstract

The aim of this investigation was to test the hypothesis that membrane permeability is necessary in bone formation using the principle of guided tissue regeneration. On the forehead of 8 rabbits, titanium test cylinders were anchored in the calvaria. These cylinders were either covered by an expanded polytetrafluoroethylene (ePTFE) membrane generating a chamber for bone formation or they were sealed off by cast titanium. The implanted cylinders were covered by resuturing the periosteum and the cutaneous flap. After 8 months of healing, new bone had formed in all cylinders in all animals irrespective of whether the chamber for bone formation was sealed off by cast titanium or the ePTFE membrane. Based on these results, we conclude that permeability of the membrane is not necessary in the guided generation of new bone.

Polyurethane and PTFE membranes for guided bone regeneration: Histopathological and ultrastructural evaluation

“…Dense barriers present important advantages about the retention of bacteria in comparison to porous membranes. Besides, the permeability and integration of the membrane are not required for the new bone formation in GBR technique (3,11). The minimum biological condition for the long term success of implanted materials is biocompatibility.…”

Periodontitis vs. Peri-Implantitis: The Same Disease? The Same Treatment?

“…To assess this problem of membrane permeability and porosity, Schmid et al (1994) conducted a study in which titanium cylinders in rabbit calvaria were covered with either an e-PTFE membrane or cast titanium sheets. After eight months of healing, new bone formed in all cases, implying that the permeability of the membrane is not necessary for guided regeneration of new bone.…”

Engineered mussel bioglue as a functional osteoinductive binder for grafting of bone substitute particles to accelerate in vivo bone regeneration

“…To date, diverse approaches have been attempted to solve these problems caused by using xenogra particles. [7][8][9][10][11][12] One major approach is to employ a physical barrier using non-resorbable materials (e.g., titanium mesh and expanded polytetrauorethylene) or resorbable materials (e.g., collagen membrane, polylactic acid, polyglycolic acid, and polyurethane).…”